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606,025 grants found
Showing 34,421 – 34,440 of 606,025 grants
Data Science Core
Core 1. Abstract Data Science Core The Data Science Core aims to streamline TeamBCP's data management and sharing by overhauling its server infrastructure and data conversion...
Quantitative Neuroanatomy
Abstract Core 2: Quantitative Neuroanatomy The neuroanatomy of orofacial circuitry has grown in complexity as viral-genetic tracing methods uncover neuronal projections of a myriad...
Advanced Nonlinear Imaging
Core 3. Abstract Nonlinear Imaging Two-photon laser scanning microscopy (TPLSM) has enabled in vivo studies on the function of neuronal circuitry. However, the penetrating depth of...
A novel enteral feeding system for the earlier and safer delivery of enteral nutrition through continuous monitoring of tip location
Abstract In the intensive care unit (ICU), enteral nutrition (EN) is a critical component of care that provides both nutritional and non-nutritional benefits including decreased ri...
Neely National Physician-Scientist Mentorship Network
The Neely National Clinician-Scientist Mentorship Network of the Triological Society was created to provide career mentorship to young otolaryngologists interested in clinician-sci...
Novel Targets in aging-associated sepsis and organ failure
Summary/Abstract This “test of concept” R21 is to explore a novel concept on the role of circular RNAs in aging-related sepsis and organ damage. Circular RNA (circRNA) is a type of...
Developing Gyrencephalic Models of TBI-Induced ADRD Neuropathology
PROJECT SUMMARY / ABSTRACT There has been considerable concern regarding the long-term effects of traumatic brain injury (TBI), largely driven by reports of neurodegenerative prote...
From functional to dysfunctional neural network dynamics underpinning memory storage and retrieval across young adult and aged mice
The goal of this project is to investigate changes in the temporal dynamics of cholinergic modulation during aging and the extent to which these changes contribute to alterations o...
Mass General Brigham Interdisciplinary Clinical Pain Research Training Program
ABSTRACTThis proposal establishes a rigorous and supportive interdisciplinary training program in clinical pain research at Mass General Brigham (MGB) in Boston. The program will s...
Weight Stigma among Doctoral Clinical Psychology Students: Examining Change and Testing Underlying Mechanisms.
Project Summary/Abstract Weight stigma is a modifiable risk factor that negatively impacts the health and well-being of higher-weight people and those with lower BMI who simply per...
University of Utah Program to Provide Pain Research Knowledge (UP3RK)
To effectively address the nation's biomedical, behavioral, and clinical pain research needs, it is imperative to prepare an interdisciplinary, diverse pool of well-trained, c...
An Application of SMART Methodology to Optimize an Intervention to Maintain Improvements in Health Behaviors in Under-resourced Patients after Phase II Cardiac Rehabilitation
PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is the leading cause of death in the United States. Cardiac rehabilitation (CR) is an evidence-based, cost-effective, and wide...
Role of Ca2+ Signaling by 3D Osteocyte Networks in Mechanoadaptive Response of the Bone Multicellular Unit
Summary Osteocytes are the most numerous cell in bone tissue, which act as mechanosensors and coordinate adaptive bone remodeling. Current model systems have been unable to unify t...
Using artificial intelligence to bridge human and murine studies of lupus nephritis progression
PROJECT SUMMARY Lupus nephritis (LN) is the most common severe manifestation of systemic lupus erythematosus (SLE) Disease progression is associated with tubulointerstitial hypoxia...
BMT Core - Oregon Health and Science University (OHSU) Consortium
PROJECT SUMMARY Allogeneic hematopoietic cell transplantation (HCT) is an essential therapeutic procedure used to enhance the outcome of patients with acute myeloid leukemia (AML)....
Synergistic Enhancement of ER proteostasis, trafficking, and lysosomes as treatments for Dementia with Lewy bodies and Parkinson’s disease-dementia
AbstractDementia with Lewy bodies (DLB), Parkinson’s disease (PD), and PD-Dementia (PDD) are all classified as synucleinopathies due to the accumulation and aggregation of a-synucl...
A Novel Therapeutic Strategy Targeting Neuroinflammation for Global Cerebral Ischemia Associated with Cardiac Arrest
PROJECT SUMMARY/ABSTRACT Each year, over 200,000 Americans suffer from global cerebral ischemia associated with cardiac arrest leading to cognitive deficits or death. While emergen...
Individual Patient Data Meta-Analysis of Red Blood Cell Transfusion Trials Comparing Liberal versus Restrictive Thresholds
Project Summary Accumulating evidence from individual clinical trials and conventional trial level meta-analysis suggests that restrictive transfusion threshold of 7 to 8 g/dL is a...
A cross-species approach to hypersomnia genetics informed by human GWAS
Idiopathic hypersomnia (IH) is a poorly understood disorder characterized by excessive daytime sleepiness despite normal nighttime sleep, often accompanied by difficulty awakening,...
Role of carnosine in peripheral arterial disease
Abstract Peripheral arterial disease is a serious manifestation of atherosclerosis in the lower extremities. Current interventions approved by FDA are either ineffective or have a...