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Cell Competition in Development and Homeostasis
A process of cell competition can remove cells that differ genetically from neighboring cells in the same tissues. Cell competition helps to eliminate sporadic aneuploid cells that...
RESTOR [Rapamycin and Everolimus Study Towards Older Rejuvenation]: An exploratory PK/PD study of mTOR inhibition in older human subjects
Pharmacological mTOR inhibition (mTORi) extends lifespan and healthspan in older mice, suggesting these medications may similarly slow the progression of age-associated deficits in...
Sperm chromatin structure and remodeling during spermiogenesis and fertilization
PROJECT SUMMARY Genetic inheritance material of a eukaryotic organism (DNA) is stored in chromosomes. Understanding of cellular activities in normal development and disease require...
Does Learning Require Calcium-Dependent Myelin Remodeling?
PROJECT SUMMARY/ABSTRACT: Myelin is essential for rapid and precise nerve signaling, and its loss in diseases like multiple sclerosis causes profound disability. Classically, myeli...
MOTS-C, APOE, and Alzheimer's disease
The 4 allele of apolipoprotein E (APOE4) is associated with accelerated aging and mortality as well as increased vulnerability to Alzheimer’s disease (AD). Although the causal lin...
Determining the Origins and Vulnerabilities of Pediatric Treatment-Induced Gliomas
ABSTRACT Pediatric treatment-induced high-grade glioma (HGG), also known as radiation-induced glioma (RIG), is an incurable secondary cancerous brain tumor that affects children wh...
Youth climate activism on social media: Building psychosocial resilience among minority youth
Project Summary/Abstract Climate change is a global crisis and an issue of intergenerational injustice, placing disproportionate and unjust harm on young people and future generati...
Using integral equations to capture spatiotemporal relations in the brain
Project Summary Medical recordings contain dynamical information that can provide quantitative pathological fingerprints that prove crucial to correct diagnostic. Brain recordings...
Investigation of the Flavin Dependent Thymidylate Synthase enzyme as a potential antimicrobial target
PROJECT SUMMARY With the increase in antibiotic resistance bacterial infections there is an urgent need for novel antimicrobial agents that target alternative cellular pathways. On...
Integrative Approaches to Study Cell-Type-Specific Protein Dysregulation in Human Diseases
Project Summary/Abstract Complex diseases are driven by intricate interactions among various cell types present at the disease sites. Recent advancements in single-cell RNA sequenc...
Mechanistic insights into the kinetics of Fc receptor-mediated placental antibody transfer to optimize maternal vaccine strategies
ABSTRACT Infants are vulnerable to infection due to their tolerogenic immune phenotype and limited adaptive immune memory, which has limited the success of newborn vaccines. Trans-...
Integrative models of nuclear DNA organization
Project Summary/Abstract The human genome organization influences gene regulation. Aberrant nuclear structures observed in cancer and conservation of common features of genome organ...
A Clinical Trial Readiness Study of Patient Reported Outcome Measures in Thrombotic Thrombocytopenic Purpura (TTP)
PROJECT SUMMARY/ABSTRACT With a prevalence of 10 cases per million, immune thrombotic thrombocytopenic purpura (iTTP) is classified as a rare disease. Yet, it has significant human...
Ribcage-abdominal movement asynchrony in persons with Parkinsons disease
Project Summary Respiratory data from five existing human subject datasets will be merged in order to comprehensively examine the dynamic and coordinated movements of the chest wal...
Yoga for Persistent Post-Surgical Pain
PROJECT SUMMARY This K01 career development award will position the candidate to become an independent translational re- searcher studying mind-body movement therapies (MBMT) for c...
Targeting mitochondrial calcium to eradicate leukemia-initiating cells
SUMMARY The goal of this project is to develop strategies for the eradication of leukemia-initiating cells (LICs) in AML patients who have received initial therapy with venetoclax...
Repurposing FDA-approved drugs for the treatment of osteoarthritis using high-throughput screening in microphysiological models
Abstract: Osteoarthritis (OA) is a painful and disabling joint disorder affecting more than 30 million Americans. Current treatments for OA are primarily to relieve pain and mainta...
Optimizing a Remote-based Physical Activity Intervention for Adults with Total Knee Replacement
Over 4 million adults are living with a total knee replacement (TKR); however, most do not achieve recommended physical activity levels. To date, physical activity interventions fo...
Regulation of distal basal cells in terminal and respiratory airway regeneration
PROJECT SUMMARY Distal (or small) airways including the terminal and respiratory bronchioles (TRB) are the sites of damage in several lung diseases. Pathologies of small airway les...
Understanding the roles of nuclear envelope proteins and DNA damage in cardiomyopathy
Project Summary Mutations in nuclear envelope proteins (NEPs) cause devastating genetic diseases, known as envelopathies, which primarily affect the heart and skeletal muscle. The...