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606,025 grants found
Showing 34,381 – 34,400 of 606,025 grants
Exerkines and the heterogeneity of peripheral and cerebral vascular adaptations to exercise training with aging in women and men
PROJECT SUMMARY/ABSTRACT Aging is the primary risk factor for cardiovascular diseases (CVD) and Alzheimer's disease and its related dementias (ADRD),1, 2 due in part to advers...
Indigenous Strengths as Solutions in a Public Health Crisis (Project ISH)
ABSTRACT The Northwest Indian College (NWIC) in partnership with the Northwest Washington Indian Health Board (NWWIHB), proposes a Phase I application in response to the OTA-23-007...
Development and Implementation of a Community-Led Research Program in the Utah Navajo Health System
The Navajo Nation represents the largest Tribal community in the U.S. and experiences high rates of morbidity and mortality attributable to substance use. Rates of alcohol-associat...
Role of Hyaluronan in IL-13-mediated COVID-19 Pathology
Project Summary Introduction: IL-13 is elevated in patients with COVID-19, in mice infected with SARS-CoV-2 IL-13 neutralization improved survival and decreased pulmonary depositio...
Mitochondrial Function and Multiomics in Aging-related Disease: Identifying Novel Biomarkers and Causal Relationships
Mitochondria play an essential role in cellular function and impact human health through varied mechanisms, including energy metabolism, cell signaling, and apoptosis. We have prev...
Equity for Parent Presence and Participation in Caregiving in the NICU
PROJECT SUMMARY/ABSTRACT While some barriers and facilitators to parent presence and participation (PPP) in the neonatal intensive care unit (NICU) have been identified, comprehens...
Non-invasive infrared light therapy and medical device to treat spinal cord injury
Currently, there are no approved interventions that significantly attenuate the acute injury and inflammatory response in the initial early (< 24 h) phase following SCI which le...
Validation of NAD+ measurements for human clinical studies: multi-method inter-laboratory standardization
Recent years have seen a surge of interest in the role of NAD in human disease and whether increasing NAD with supplements such as nicotinamide riboside (NR) or nicotinamide mononu...
The role of the microbiome in hepatic encephalopathy pathogenesis and treatment
Project Summary/Abstract Hepatic encephalopathy (HE) is a complication of cirrhosis characterized by cognitive, psychological, and motor dysfunction that is associated with decreas...
ATP1B3: novel regulator of T cell-mediated immunity
Project Summary T cells are key components of immune responses to infection and in autoimmunity. Like all cells, they require ion channels and transporters for their function. Chan...
Phase 1 First in Human Trial to Assess Safety and Tolerability of the Novel ACK1 Inhibitor (R)-9b in Patients with Prostate Cancer
Abstract Prostate cancer (PC) is one of the leading cause of cancer deaths among American men. Advanced PC patients often receive androgen deprivation therapy, but, the recalcitran...
Avoiding Cardiovascular Complications in Liver Transplantation through Novel Studies (ACCT NOW) in Hypertension
PROJECT SUMMARY One in three liver transplant recipients experiences a cardiovascular event within one year of transplant because of immunosuppression medications and a high preval...
Rewired Metabolism and Immunosuppression in MYCN-driven Neuroblastoma
PROJECT SUMMARY Amplification of the oncogene MYCN drives high-risk progressive disease, resistance to therapy, and a poor overall survival rate below 45% for high-risk neuroblasto...
Advancing VR-based attentional bias as a biomarker for tobacco use disorder
PROJECT SUMMARY There are few effective treatment options for smoking cessation. The identification and validation of reliable biomarkers for tobacco use disorder has the potential...
Evolution of the Chicago Classification: Bridging Physiology and Mechanics
PROJECT SUMMARY Swallowing difficulties are extremely common and result in substantial morbidity, reduction in the quality of life, and mortality related to malnutrition and compli...
Development of Polygenic Scores for Medication Response in Diverse Populations
Polygenic scores (PS) represent an exciting translational application of genomic information that can mitigate some short comings of traditional genetic approaches, and which have...
Mobile Health for Migrant Health (mHealth-4-Mhealth): Assessing the Effectiveness of Implementing an mHealth Program to Increase COVID-19 Testing and Treatment Among Rural Migrant Families
PROJECT SUMMARY/ABSTRACT Migrant agricultural workers and their families face formidable challenges in accessing COVID-19 testing, treatment, and preventive measures due to geograp...
Career Development for Legally Trained Interdisciplinary Researchers in Aging and Health Sciences
Project Summary The value of legally trained researchers is well established, yet there is a dearth of training and mentorship opportunities to help develop sustainable and effecti...
Mechanism of intestinal TET3-mediated DNA oxidation and transcriptional regulation
PROJECT SUMMARY DNA methylation dynamics in mammals are an integral component of the epigenetic regulatory machinery. Methylated DNA functions as a repressive mark for gene express...
Using Implementation Science to Enhance HIV Prevention for Young Men who have Sex with Men
PROJECT SUMMARY/ABSTRACT Background: Young men who have sex with men (YMSM) bear a disproportionate burden of HIV incidence in the U.S. Though pre-exposure prophylaxis (PrEP) use i...