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606,025 grants found
Showing 34,401 – 34,420 of 606,025 grants
Impact of HIV co-infections and comorbidities on circadian rhythm in the liver
Project Summary HIV-associated comorbidities, co-infections, and complications (CCCs) can exacerbate the health burden in people living with HIV (PLWH). Using innovative cell cultu...
Versatile genomics platform for unbiased analysis of chromatin-associated RNAs and nascent transcripts
SUMMARY Aging and neurodegenerative diseases, such as Alzheimer’s disease and related dementias (AD/ADRD), are associated with alterations in nuclear structure, chromatin dysregula...
Molecular phenotypes of frailty in lung transplantation
PROJECT ABSTRACT I am an Associate Professor and lung transplant pulmonologist deeply committed to mentoring. I have developed a well-funded research program focused on applying ag...
SimuVersity Medical Center: Pain and opioid management training in diverse patient populations
Summary Management of chronic pain and opioid use/misuse is challenging for clinicians and students, especially when working with diverse and underserved patient populations. Not a...
L-type calcium channels in Alzheimer’s disease pathophysiology
Abstract The calcium hypothesis of Alzheimer’s disease (AD) links calcium dysregulation and the amyloidogenic pathway to cognitive dysfunction and tau pathology in AD. Calcium dysr...
Development of Attentional Biases for Affective Cues in Infants of Mothers with Depression
PROJECT SUMMARY/ABSTRACT The link between depression in mothers and their children is well established, and there is growing evidence thatchildren’s biased attention to facial disp...
Mechanics of Brain Folding in Human Infants Evaluated Using MRI
Abstract In human brain development, the third trimester represents a critical period of cortical expansion, folding, and white matter organization. Deviations from the normal deve...
Role of FBW7 in cystic diseases of the kidney
Polycystic Kidney Disease is the common denominator in several phenotypically diverse genetic conditions of the kidney. These diseases include Autosomal Dominant Polycystic Kidney...
RUNX proteins define opposing fates in the male germline
PROJECT SUMMARY / ABSTRACT Compelling evidence from human epidemiological studies and model systems indicate that many adult diseases can be traced to deficits far earlier in devel...
Elucidating the roles of adipocyte KAT8 in lipoatrophy and systemic insulin resistance
Project Summary: Adipocytes are highly specialized cells that have a number of functions including lipid storage, insulin sensitivity, and significant endocrine capabilities. Obesi...
Pathogenic Germline Mutations in Barrett's Esophagus
PROJECT SUMMARY: Esophageal adenocarcinoma (EAC) remain among the most lethal cancers, with a 5- year survival rate of ~20%. Present in 1-6% of the general population, Barrett’s Es...
Engaging communities to develop and evaluate communication strategies for HIV vaccine and prevention uptake among Black women in the Southern US
Project Summary This proposal addresses NIMH’s call for HIV vaccine preparedness and “HIV vaccine-related” communication research (Notice of Special Interest NOT-MH-21-105). Though...
Clinical trial of omalizumab for allergen sensitized and exposed individuals with COPD
Project Summary Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease with significant variation in disease manifestation, progression, and outcomes. There is inc...
High- and low-level computations for coordination of orofacial motor actions
Overall - Abstract High- and low-level computations for coordination of orofacial motor actions Neuronal circuits in the brainstem integrate control of life-sustaining motor action...
Confluence of high- and low-level signaling for the control of orofacial rhythmic motor actions
Project 1. Abstract Confluence of high- and low-level signaling for the control of orofacial rhythmic motor actions Orofacial actions are nominally comprised of two components: a r...
The shape, movement, and signals of active sensors: Modeling the biomechanics of deformable orofacial organs
Project 2. Abstract The shape, movement, and signals of active sensors: Modeling the neuronal control and biomechanics of deformable orofacial organs (Golomb as lead; all PIs contr...
Identifying brainstem oscillators and other low-level mechanisms controlling tongue and jaw movements
Abstract- Project 3 Identifying brainstem oscillators and other low-level mechanisms controlling tongue and jaw movements All vertebrate species depend on feeding for survival. Lik...
Neuroanatomical and molecular architecture of high- and low-level circuits controlling orofacial movements
Project 4 Summary Motor circuits in the vertebrate brain are arranged hierarchically. Low-level circuits in the brainstem and spinal cord – such as the oscillators and pattern gene...
Top-down and bottom-up signals for flexible orofacial behaviors
Abstract Project 5: Top-down and bottom-up signals for flexible orofacial behaviors (O’Connor as lead) Orofacial behaviors involve sequences of individual motor actions — such as c...
Administrative Core
Project Summary/Abstract – Administrative Core The Administrative Core is the organizational underpinning for the proposed studies. These are organized into five projects across fo...