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606,025 grants found
Showing 34,461 – 34,480 of 606,025 grants
Advancing, Expanding, and Streamlining University of New Mexico Health Sciences Center Animal Resource Facility Rodent Housing Capabilities
PROJECT SUMMARY/ABSTRACT The aim of this R24 proposal entitled “Advancing, Expanding, and Streamlining University of New Mexico Health Science Center Animal Resource Facility Roden...
Epilepsy in Alzheimer's disease and related dementias
PROJECT SUMMARY/ABSTRACT Candidate and Goals: Dr. Ifrah Zawar is an Assistant Professor of Neurology at the University of Virginia (UVA) with clinical expertise in neurology and ep...
HEARTLINK: Harnessing Effective Approaches for Research and Training in Global Cardiovascular Dissemination, Implementation, and Knowledge Translation
PROJECT SUMMARY In this K24 application, I seek to enhance my capability as a leader in patient-oriented cardiovascular research and mentorship at Washington University. The propos...
Defining the role of single-cell heterogeneity in bacterial vaginosis
PROJECT SUMMARY/ABSTRACT A major challenge in bacterial pathogenesis is the prevention and treatment of polymicrobial diseases, as microbe-microbe interactions alter the initiation...
Prenatal exposure to cannabis and child cardiometabolic health outcomes
Cannabis use among pregnant people is on the rise. This trend is likely to be continue, especially among people who are younger or those live in states where cannabis is legal. Yet...
Proof of Concept Trial of a Mindful Walking Intervention for Black Women with Hypertension
ABSTRACT Hypertension disproportionately affects Black women and is a key risk factor for cardiovascular disease, a leading cause of death. As many as 39.9% of Black women have hyp...
Investigating Afferent Baroreflex Dysfunction in Hypertension
PROJECT SUMMARY Hypertension is a major risk factor for cardiovascular disease, the leading cause of mortality globally. Despite major milestones in understanding the pathophysiolo...
Effect of a technology-based collaborative care model on persistent hypertension and preventive careattendance among postpartum people with hypertensive disorders of pregnancy
PROJECT SUMMARY/ABSTRACT Uncontrolled hypertensive disorders of pregnancy (HDP) are a major source of maternal mortality. National guidelines recommend blood pressure (BP) measurem...
Structure-function studies of DELE1-mediated activation of the integrated stress response
ABSTRACT Protein homeostasis (proteostasis) is tightly regulated by an intricate network of finely tuned cellular pathways. Among the pathways required for responding to internal o...
Developing an Inclusive Measure of Financial Hardship for People Living with Dementia and their Care Contributors
PROJECT SUMMARY The number of individuals with Alzheimer’s disease or Alzheimer’s disease-related dementias (AD/ADRD) in the U.S. is projected to increase to 9 million by 2030 (fro...
Impact of Grin2b/GluN2B disruption on dopaminergic function and related behavior
PROJECT SUMMARY The gene that encodes the NMDA-GluN2B subunit (GRIN2B) is one of the top 10 genes implicated by de novo, gene-disrupting single nucleotide variants (SNVs) in autism...
The Role of Chemical Exposures in Alzheimer's Disease (AD) and its Trajectory
It has become increasingly clear that environmental exposures, the genome, gut microbiome, diet, and lifestyle all affect an individual’s metabolic state contributing to brain heal...
Development of Measure(s) of Financial Hardship and Health Disparities among Individuals Living with ADRD and Their Family Caregivers
Abstract The treatment and care of Alzheimer's disease and related dementias (ADRD) place a huge burden on individuals, families, and healthcare systems. The estimated lifetim...
Diabetes Brain and Cognitive Development-Type 1 (DBCD-T1)
ABSTRACT Glucose is the most important source of energy for proper brain development and functioning; therefore, any imbalance in glucose is associated with changes in neurodevelop...
MDSRC for Next Directions in Muscular Dystrophy Research
Abstract The Center for Gene Therapy at the Abigail Wexner Research Institute of Nationwide Children’s Hospital (NCH) hosts a robust and active research community in the muscular d...
MDSRC Administrative Core
Abstract The Center for Gene Therapy at the Abigail Wexner Research Institute of Nationwide Children’s Hospital (NCH) and the OSU/NCH Center for Muscle Health and Neuromuscular Dis...
MDSRC Training Core
Abstract The outstanding training environment in muscle disease pathogenesis and treatment that exists in Columbus, Ohio at Nationwide Children’s Hospital (NCH) and The Ohio State...
Muscular Dystrophy Cell Line and Serum Banking Core
Muscular Dystrophy Cell Line and Serum Banking Core ABSTRACT The over-arching theme for this MDSRC grant application is to accelerate the translation of novel genetic therapies fro...
(Project 1) Bicistronic Gene Therapies for the Muscular Dystrophies
ABSTRACT The goal of this proposal is to complete the remaining pre-clinical proof of concept and safety studies required to file a pre-IND application with the FDA for a first-in-...
(Project 2) Development of U7snRNA Vectors for Dystrophinopathy
ABSTRACT Duchenne muscular dystrophy (DMD) typically results from mutations in the DMD gene that disrupt the open reading frame, resulting in no dystrophin protein, whereas the mil...