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606,025 grants found
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Bridge to Belonging (B2B): Peer led intervention to reduce loneliness and depression among older gay and bisexual men
PROJECT SUMMARY Older gay and bisexual men living with HIV (OGBMLH) are twice as likely to experience depression compared to heterosexual and HIV-negative counterparts. Depression...
Software Development and Cadaveric Testing of Deformable Registration Pipeline in Novel Camera-Projector Surgical Navigation Device
ABSTRACT The purpose of this Phase I project is to build, integrate, and test a deformable registration pipeline for PRISM in order to make its markerless registration process more...
A National Survey on Naloxone Use and Access
ABSTRACT Improving naloxone access is a central pillar of the policy landscape to curb rising overdose deaths rates in the United States. In particular, improving access among “lay...
HIV viral suppression and prevention of postpartum weight retention in South Africa: A pilot trial
PROJECT SUMMARY/ABSTRACT Availability of antiretroviral therapy (ART) coverage to pregnant women for life through Option B+ has been a major advance in sub-Saharan Africa for mater...
opioid receptor activation of the carotid body mitigates OIRD by fentanyl
ABSTRACT Fentanyl is a widely used opioid in the clinic for relieving chronic pain. Fentanyl abuse leads to mortality due to opioid-induced respiratory depression (OIRD). OIRD is a...
NUCATS T32
PROJECT SUMMARY/ABSTRACT We propose an innovative T32 postdoctoral training program, Equitable TRanslational science to Accelerate Impact of New innovations (E-TRAIN) T32, for the...
Mapping the landscape of the aged human brain for neurodegenerative disease models
Summary Aging is the main contributor to many human neurodegenerative diseases, such as Alzheimer’s disease (AD), that are common, progressive, and have limited therapeutic options...
Team science approach to integrate machine-learning models and functional genomics to study aging in the context of Alzheimer's disease
PROJECT SUMMARY Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by progressive cognitive decline and dementia. It accounts for approximately...
Connecting Neuronal Hyperexcitability and Sex Differences in Alzheimer's Disease (AD) using biophysically-informed in-silico brain simulations and experimental data from mouse models of AD
The mechanism underlying neuronal hyperexcitability, as a result of excitation-inhibition (E-I) imbalance, leading to cognitive deterioration in Alzheimer’s disease (AD) is not ful...
Multifactorial Asthma Determinants in Underresourced Pediatric Populations
PROJECT SUMMARY/ABSTRACT Pediatric asthma, the most common chronic condition of childhood, has known disparities, particularly among racial and ethnic minority children who experie...
Social Modifiers of Primate Lifespan
Social Modifiers of Primate Lifespan People who are socially isolated or low socioeconomic status suffer from poorer health and shorter lives. Social factors also impact the surviv...
Multiscale Modeling of Brain Aging and Alzheimer’s Disease with MRI, Pathology and Proteomics
Project Summary Aging has a pronounced effect on the human brain, yet differences between individuals can be substantial, and are likely influenced by genetic, environmental lifest...
The pathogenic effects of senescent cells on their microenvironments and their role in human brain aging
PROJECT SUMMARY Senescent cells were hypothesized to contribute to development of Alzheimer’s Disease and Related Dementias (ADRD) by secreting inflammatory factors in their surrou...
Relationships between immunosenescence, brain aging biomarkers, and cognition across nonhuman primate species of differing lifespans
Project Summary The world’s population is aging, which brings about huge scientific challenges. Since the biological process of aging is by far the greatest risk factor for most ch...
Intergenerational Community Driven Training in Alzheimer's Disease Research: An AI+X Approach
PROJECT SUMMARY The development of Alzheimer's Disease (AD) and AD Related Dementias (ADRD) is impacted by biological, clinical, socio-demographic, and lifestyle factors. Ther...
Improving causal inference in Alzheimer's Disease prevention research on modifiable risk factors: the Triangulation of Innovative Methods to EndAD (TIME-AD) project
OVERALL COMPONENT PROJECT SUMMARY Research on Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) has identified several promising risk factors which could guid...
Core A: Administrative Core
ADMINISTRATIVE CORE SUMMARY The Administrative Core will administer and lead the P01, including the other four Cores and the four Projects. The Administrative Core is led by TIME-A...
Core B: Analytics Core
ANALYTICS CORE SUMMARY The Analytics Core will support all four research components of the TIME-AD program, ensuring coordinated statistical approaches and principled decisions on...
Equity and Dissemination Core
EQUITY AND DISSEMINATION CORE SUMMARY The purpose of the Equity and Dissemination (E&D) Core is to maximize the impact of the Improving causal inference in AD projects for prev...
Core D: Cognition, Exposure, and Covariates (CEC) Data Core
COGNITION, EXPOSURE, AND COVARIATES DATA CORE SUMMARY The TIME-AD project will use multiple data sources to enhance understanding of how AD/ADRD risk is affected by four high prior...