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606,025 grants found
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Core E: Genetic and Policy Data Core
GENETIC AND POLICY DATA CORE SUMMARY TIME-AD will be supported by a specialized Genetics and Policy Data (GPD) Core focusing on causal identification based on quasi-experimental so...
Project 1: Alcohol use and AD/ADRD risk: innovative methods and data for new insights
PROJECT SUMMARY The effects of alcohol use on Alzheimer’s Disease and Alzheimer’s Disease Related Disorders (AD/ADRD) remain uncertain. Long hypothesized to have a J-shaped relatio...
Project 2: Depression and chronic pain: Modifiable targets for prevention of AD/ADRD
Summary/Abstract Depression is a highly prevalent and modifiable risk factor for Alzheimer’s Disease and Alzheimer’s Disease Related Disorders (AD/ADRD). Severe and untreated depre...
Project 3: Prevention and Treatment of Hearing and Vision Impairments for Reducing AD/ADRD risk
PROJECT SUMMARY/ABSTRACT Sensory impairments, including hearing and vision loss, affect up to 40% of older adults and have been linked to higher risk of Alzheimer’s disease and Alz...
Project 4: Social isolation as a driver of AD/ADRD incidence and disparities
PROJECT SUMMARY Social isolation, defined as an objective state of limited to no social contact, impacts millions of older adults, with prevalence estimates varying from 10-25% acr...
Mechanisms Underlying Heterogeneity of Cognitive Outcomes in Synucleinopathy
OVERALL ABSTRACT/SUMMARY The mission of this Penn PO1 Center on “Mechanisms underlying heterogeneity of cognitive outcome in synucleinopathy” is to understand why the same underlyi...
Core A: Administrative Core
ADMINISTRATIVE CORE SUMMARY/ABSTRACT The Administrative Core of the proposed NIA PO1 Center at the University of Pennsylvania (Penn) Perelman School of Medicine (PSOM) is key to ac...
Core B: Clinical Core
PROJECT SUMMARY/ABSTRACT (CLINICAL CORE) The Clinical Core of the proposed NIA P01 at the University of Pennsylvania (UPenn) Perelman School of Medicine will be crucial to accompli...
Core C: Resource Core
Resource Core: Abstract Nearly all neurodegenerative disorders are characterized by progressive accumulations of pathological deposits of disease protein aggregates within cells, b...
Core D: Data Management and Statistics Core
Data Management and Statistics Core Core Leader: Sharon X. Xie; Co-Investigator: Corey McMillan Summary/Abstract: Data Management and Statistics Core The Data Management and Statis...
Project I: Alpha Synucleinopathy in the Human Brain Connectome
PROJECT I: ABSTRACT The overall objective of this project is to develop predictive models of alpha-synuclein (aSyn) propagation in the human brain in Lewy body dementia (LBD) patie...
Project II: Deciphering the Signatures of Pathological Changes on Alpha-Synuclein
PROJECT II: Summary/Abstract Pathological alpha-Synuclein (aSyn) accumulates in neurons as Lewy bodies (LBs) and Lewy neurites (LNs) in Lewy body diseases (LBD) including dementia...
Project III: Heterogeneity of Outcomes in Synucleinopathies: Insights from Genomics and Proteomics
PROJECT III SUMMARY/ABSTRACT Heterogeneity of Outcomes in Synucleinopathies: Insights from Genomics and Proteomics While patients with Lewy body disorders (LBD) share the core feat...
Project IV: In Vivo Dissection of Genetic Modifiers on Different Stages of Synucleinopathy
PROJECT SUMMARY Project IV: In Vivo Dissection of Genetic Modifiers on Different Stages of Synucleinopathy Lewy body diseases (LBDs) are defined by the presence of intraneuronal in...
Understanding Integration in Oncology Care and Association with Quality and Outcomes
PROJECT SUMMARY/ABSTRACT: Overall Program Project This Program Project seeks to understand features of care integration in oncology that are associated with higher-quality care del...
Administrative Core
ADMINISTRATIVE CORE PROJECT SUMMARY/ABSTRACT The Administrative Core provides coordination and administrative oversight for the Program Project, “Understanding Integration in Oncol...
Project 1: Care Integration for Patients with Cancer Treated in Health Systems
PROJECT SUMMARY/ABSTRACT: Project 1 - Care Integration for Patients with Cancer Treated in Health Systems This Project focuses on care integration for patients with cancer who are...
Project 2: Care Integration for Patients with Cancer Treated in Independent Practices
PROJECT SUMMARY/ABSTRACT: Project 2 - Care Integration for Patients with Cancer Treated in Independent Practices The goal of this Project is to describe care integration for patien...
Project 3: Care Integration for Patients with Cancer Receiving Post-Acute Care and Hospice
PROJECT SUMMARY/ABSTRACT: Project 3 - Care Integration for Patients Receiving Post-Acute Care and Hospice This Project focuses on care integration for patients with cancer who are...
Project 4: Care Integration for Patients with Cancer Using Specialty Pharmacies
PROJECT SUMMARY/ABSTRACT: Project 4 - Care Integration for Patients with Cancer Using Specialty Pharmacies This project aims to examine the integration of specialty pharmacies into...