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606,025 grants found
Showing 25,501 – 25,520 of 606,025 grants
Sex-dependent aging mechanisms of retina and visual cortex
PROJECT SUMMARY: Aging induces changes in the visual system, including decreased visual acuity, contrast and wavelength sensitivity, and processing of visual information. These cha...
Aging and Health in a Changing Climate
PROJECT SUMMARY Older adults are particularly vulnerable to health impacts from climate-related events such as heat waves, hurricanes, wildfires, and floods. These impacts include...
APOE Genotype Mediated Effects on Alzheimer Disease Risk and Mechanisms
ABSTRACT The APOE ɛ2 and ɛ4 alleles are by far the strongest and most well-established common genetic risk factors for Alzheimer disease (AD). The deleterious effect of ɛ4 on AD ri...
IL-6 Trans-signaling increases vulnerability to Postoperative Cognitive Decline in Aging and Alzheimers Disease
Abstract Surgical patients expect to return to their pre-morbid state after the procedure for their underlying condition; unfortunately, perioperative neurocognitive disorders (PND...
Improving intestinal symptoms in a Congenital Disorder of Glycosylation
PROJECT SUMMARY/ ABSTRACT Congenital disorders of glycosylation are multi-system inherited diseases, which affect the amount of glycosylation added to proteins. For patients with m...
Generational Overlap: Changing Demography, Shared Lifetimes, and Family Resources
Project Summary/Abstract Kinship ties form the bedrock of societies and provide meaning in terms of roles, obligations, and responsi- bilities. Generational overlap in the form of...
Effect of Cognitive Empathy Training on Dementia Caregivers
Project Summary An estimated 5.8 million Americans age 65 and older are living with Alzheimer’s dementia in 2020. The majority of these individuals are cared for at home by family...
Personal Values in Dementia Experience, Caregiving, and Research
PROJECT SUMMARY/ABSTRACT Dementia caregivers, clinicians, and researchers can experience deep ethical conflicts when people with dementia express strong preferences about personal...
The role of neuropeptides in host-parasite interactions: From molecular signaling to behavioral responses
Parasites can be found everywhere, playing crucial roles in ecological, economical, and evolutionary contexts.Despite this, host-parasite interactions, particularly those involving...
Sperm Evolution and Speciation in Littorina
Sperm cells are the most morphologically diverse animal cells, but how does that diversity arise, and what are its evolutionary consequences?This project investigates the causes an...
Federated Learning-based Distributed Control for Heterogeneous Platoons of Connected Autonomous Electric Vehicles
To promote the EU's sustainable development of environment and economy, EU planned to reduce emissions from conventional vehicles in European Green Deal.Heterogeneous platoons...
Transnational Fatherhood, Negotiating Masculinity and Parental Care in the Digital Communication Era
The research proposal aims at investigating the relationship between transnational fatherhood, negotiation of masculinity, and parental care practices among Pakistani migrant men i...
Microfluidics-assisted synthesis of Dapagliflozin-loaded liposomes for heart fibrosis: Development of a 3D bioprinted multicellular in vitro model
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, with half of CVDs deaths being caused by coronary artery disease.Myocardial infarction is the most common c...
Braid groups and related structures
The braid group is a fundamental and classical object arising in both algebraic and geometric contexts.This project will explore the various actions of the braid group on spaces wi...
A new diagnostic test for AD based on a neurotoxic Abeta Dimer
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease and future treatments are likely to be most effective in early stages, prior to the onset of dementia. The first...
Vascular Imaging Biomarker Relationships to Alzheimer’s disease (VIBRA)
PROJECT SUMMARY / ABSTRACT Improving vascular health is a potential strategy to delay the onset of Alzheimer's disease (AD) and related dementias (ADRD). The overlap of cerebr...
Air pollution, the blood and brain metabolome and their effects on Alzheimer's disease and related dementias
Abstract Exposures to ambient air pollution, especially fine particulate matter (PM2.5), have been associated with increased risks of many chronic illnesses, including Alzheimer’s...
Preparing Assisted Living Staff to Care for Persons with Dementia: Palliative Care Education in Assisted Living for Dementia Care Providers
PROJECT SUMMARY/ABSTRACT More than one-third of the one million older adults living in assisted living (AL) communities in the United States have a diagnosis of Alzheimer's di...
Understanding Ambulatory Care Utilization in Alzheimer's Disease and Related Dementias (ACUA)
Dementia is a disease characterized by a loss of memory and other cognitive functions that is severe enough to interfere with daily living. In 2023, an estimated 6.7 million Americ...
The cGMP-signaling axis in intestinal aging.
Along with the aging of our population comes important socioeconomic costs due to the numerous healthcare concerns of the elderly. Changes in the aging gastrointestinal tract under...