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606,025 grants found
Showing 25,521 – 25,540 of 606,025 grants
Substance of Change: Evaluation of Web-Based Training for Mentors and Staff Serving Youth Impacted by Substance Misuse
“Substance of Change: Evaluation of Web-Based Training for Mentors and Staff Serving Youth Impacted by Substance Misuse” Approximately 1.6 million youth between the ages of 12-17-y...
Investigation of active kinome networks in Alzheimer's dementia.
Summary This is a revised R01 application from a team of established investigators who bring complementary expertise for a multi-omics, hypothesis generating, series of experiments...
Development of Biotherapeutic Nanogels for Alzheimers Disease Treatment
Development of Biotherapeutic Nanogels for Alzheimer’s Disease Treatment. PROJECT SUMMARY (ABSTRACT): Alzheimer's disease (AD) is a neurodegenerative disease that has affected...
Telerehabilitation In The Home After Stroke: A Randomized, Controlled, Assessor-Blind Clinical Trial (The TR-2 Trial)
Project SummaryHigh doses of intensive rehabilitation therapy improve functional outcomes after stroke, but most patients do not receive this, for reasons that include limited acce...
Defining the role of mechanotransduction pathways in activating cardiac fibroblasts to cause fibrosis after myocardial infarction.
PROJECT SUMMARY/ABSTRACT Fibrosing cardiac diseases cause 25% of deaths in the United States. Fibrosis is a key pathological hallmark of nearly all cardiac diseases, including hype...
Turning back biological clock: mechanisms of age reversal in a whole organism
ABSTRACT Reversing the negative effects of aging has the potential to delay age-related diseases and significantly improve the quality of life in old age. In recent findings, we re...
The Circadian Clock Coordinates Animal and Microbial Metabolism
Project Summary Our circadian clocks synchronize physiological processes and behaviors like eating and sleeping to environmental light cycles. The central clock located in the brai...
Unraveling Fundamental Mechanisms of Interorgan Crosstalk in Osteoarthritis
PROJECT SUMMARY Osteoarthritis (OA), the loss of cartilage lining articular joints, is the leading cause of pain and disability worldwide. There are no existing treatments for OA a...
Genomic recording systems to reveal evolutionary modifications in primate neocortex
Project Summary/Abstract Primate brains develop following an exquisitely conserved Bauplan that is shared with other mammals, yet also possess advanced cognitive capabilities. Thes...
Uncovering cellular and molecular adaptations for whole-organism rejuvenation
PROJECT SUMMARY Organismal aging and age-associated diseases, including many cancers, are driven by the slow accumulation of damage in cells and tissues over time. In some instance...
Translating a Novel Therapeutic Approach to the Treatment for Idiopathic Pulmonary Fibrosis
Project Abstract The goal of this Fast-Track SBIR application is to develop a novel drug candidate to treat Idiopathic pulmonary fibrosis (IPF). IPF is a fatal disease that remains...
Cogito: A turnkey solution for rapidly developing, evaluating, deploying, and scaling digital therapeutics
Digital therapeutics are transforming healthcare. Digital therapeutics are clinical-grade software used to prevent, treat, or manage a medical disorder or disease. A large body of...
A spatial view of hematopoietic regeneration dynamics in the bone marrow
Project Summary: The regeneration of blood and immune cells relies on hematopoietic stem and progenitor cells (HSPCs) that reside in the bone marrow. HSPCs not only sustain homeost...
Integration of an opioid dispensing, monitoring, and disposal platform with a hospital pharmacy to reduce opioid use by discharged emergency department patients
SUMMARY The primary goal of this project is to integrate and assess the practicality of a closed-loop medication management system dispensed through a hospital-based pharmacy with...
Therapy for Fecal Incontinence and FecalUrgency
Fecal incontinence and fecal urgency (FI/FU) are extremely inconvenient and stigmatizing conditions that are common in the elderly, nursing home residents, women (due to anal damag...
A Novel Probiotic with The Potential for Long-term Management of Obesity and Insulin Resistance
PROJECT SUMMARY/ABSTRACT: Obesity is a major public health problem in the United States. It is linked to insulin resistance and type 2 diabetes, two devastating diseases that affec...
Therapeutic Approach to Clear sdLDL from Circulation
Project Abstract Cardiovascular Disease (CVD) is a significant threat in the United States and developing countries across the globe. Widely associated with elevated low density li...
A community-based adaptation of a peer-led intervention to address alcohol use and HIV risk in pregnant women in South Africa (Mentor Moms+)
PROJECT SUMMARY The syndemic of alcohol use and HIV risk in pregnant and lactating people (PLP) threatens the health of mother, fetus, children and families in South Africa. PLP li...
Decision Support System for Personalized Care of Ventilated Patients using Esophageal Pressure
Project Summary Mechanical ventilation is an essential intervention for many patients but is associated with a risk of preventable complications and is a modifiable determinant of...
Definitive (GLP) Toxicity and Toxicology Studies for a Novel Small Molecule for Protection Against Cardiotoxicity in Triple Negative Breast Cancer
Abstract The overall goal of this program is the development and commercialization of a novel, safe, and effective, therapy that synergizes with anthracyclines, such as Doxorubicin...