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606,025 grants found
Showing 25,581 – 25,600 of 606,025 grants
Statistical Methods and Data Core
PROJECT SUMMARY/ABSTRACT: Statistical Methods and Data Core The Statistical Methods and Data Core will provide technical expertise in data and analysis and develop new methods to d...
Sensor-Like LC-MS Platform for Rapid Online Monitoring of Metabolites in Biological Systems
Project Summary Our research program focuses on the development of analytical tools to enhance the characterization of complex biological systems. For rapid, real-time analysis of...
Great apes and the evolutionary origins of long life: the influences of early life adversity on lifespan and individual frailty in wild chimpanzees and gorillas
PROJECT SUMMARY While one of the most remarkable features of the human species is our capacity for extreme longevity, understanding the marked variation in life spans within and be...
Elucidating chronic liver disease pathways using somatic genetics
PROJECT SUMMARY Chronic liver disease is common and its pathogenic mechanisms are complex. There are no high throughput genetic methods to uncover mechanisms that drive progression...
Development of large-scale composite null hypothesis testing approaches to perform translational genetics analyses
Abstract/Project Summary Germline genetics research often relies heavily on large-scale hypothesis testing to detect associations between complex traits and their risk mutations. T...
Accelerating Behavioral and Social Sciences through Ontology Development and Application: NIH Research Network Project (APRICOT).
Title: Advancing Prevention Research In Cancer through Ontology Tools (The APRICOT project) Abstract Progress in behavioral research in cancer prevention is hampered by imprecision...
Chemical proteomic mapping and functional manipulation of extracellular proteinaceous cysteines
Project Summary Around 262,000 cysteine residues are intricately distributed throughout the human proteome. These cysteinesplay pivotal roles in influencing protein folding, stabil...
A reproducible database for untargeted metabolomics data processing across laboratories
Project Summary Scientific teams led by Prof. Oliver Fiehn (UC Davis), Prof. Charles Evans (University of Michigan) and Dr. Tom Metz (Pacific Northwest National Laboratory) will de...
Treatment of Health Complications due to Female Genital Mutilation/Cutting in Tanzania: Curriculum Build, Implementation, and Evaluation
ABSTRACT Female genital mutilation/cutting (FGM/C) affects girls and women throughout the world, with 3 million girls cut each year. The highest rates of FGM/C are in East Africa....
Genes, neighborhoods, and alcohol misuse from adolescence to mid-adulthood in the Add Health study
PROJECT SUMMARY Where one lives is an important contributor to disparities in health behaviors and outcomes, but it has been difficult to draw firm conclusions on the relations bet...
Computational Framework for the Mechanistic Studies and Physics-Informed Prediction and Design of Photoenzymes
A robust enzyme design strategy will profoundly impact human health, such as by achieving asymmetric synthesis of pharmaceuticals not easy to be achieved by small-molecule catalyst...
Developing Switchable and Functional Fluorophores For Multi-Functional Super-Resolution Microscopy
Project Summary The overarching goal of the PI’s research program is to decode the intricate biophysical and biochemical functions in diverse molecular processes underlined by the...
Observational causal inference with infectious disease outcomes
Project Summary Infectious disease is a leading cause of global morbidity and mortality. Transmission dynamic models have played a critical role in guiding interventions related to...
The Effects of Changing Health Care Markets on Cardiovascular and Cerebrovascular Care and Outcomes
PROJECT SUMMARY The health care delivery system is undergoing tremendous changes, with increasing consolidation from mergers and acquisitions, as well as openings and closings of h...
Validation of neuronal senescence as a target for chronic pain in aging
Project Summary Aging is a major risk factor for the development of chronic pain with 50% of adults over the age of 65 suffering from at least one chronic pain condition. Unfortuna...
Expanding the capabilities and usage of the TELSAM protein crystallization chaperone
There is a critical need for new protein crystallization methods that are more successful and require less labor, time, and resources. Lack of straightforward methods to successful...
Clinical Effectiveness of Exercise After an Implantable Cardioverter Defibrillator (ICD)
Abstract The goal of this study is to test the effectiveness and describe implementation of a home based exercise intervention for persons with an implantable cardioverter defibril...
Promoting Health Aging through Semantic Enrichment of Solitude Research (PHASES)
Research on solitude often highlights the risks of spending time alone with a focus on negative outcomes, such as mortality and depression. When positive outcomes are associated wi...
Foundational Investigations into Bacterial Surface Glycan Dynamics
Project Abstract Bacteria have existed for millions of years and have evolved sophisticated methods of communication. One primary mechanism is through the glycans on their surface,...
Breathing Easier in Schools: Enhancing Adoption, Fidelity, and Effectiveness of the SAFE School Program through Innovation Implementation Strategies
PROJECT SUMMARY Asthma contributes to chronic absenteeism and learning loss in U.S. school children and respiratory distress is the leading cause of 9-1-1 calls from schools. When...