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606,025 grants found
Showing 24,841 – 24,860 of 606,025 grants
Developing an "Out of the Box" Quality Improvement Library for Lung Diseases
Project Abstract Phrase Health is a clinical decision support (CDS) analytics company that empowers health systems to efficiently incorporate scientific knowledge into high value c...
Quantitative measurement of PlGF using a rapid, low-cost, point-of-care (POC) diagnostic platform for prediction and detection of pre-eclampsia
Project Summary The maternal morbidity and mortality associated with gestational hypertension, and specifically pre-eclampsia, remains a serious issue within the United States, aff...
Sexual health behaviors among US adolescents and young adults
ABSTRACT Rough sexual behaviors (i.e., sex that involves slapping, hard spanking, punching, choking, and/or other physically aggressive acts) appear to be increasingly common among...
A Stand Alone Wearable for Tracking Environmental Exposure and Evaluating Respiratory Response
PROJECT SUMMARY Every year, 1.5 million emergency room visits are COPD exacerbates. Lack of remote patient management and telehealth primes most COPD patients to visit the emergenc...
Software Tool for Optimization of CRT
ABSTRACT Heart failure (HF) is a nationwide epidemic. Many HF patients are presented with left bundle branch block (LBBB) morphology and mechanical dyssynchrony, which are strong p...
Spatially resolved multi-omics sequencing of FFPE tissues at cellular level
Project Summary Studying tumors in a spatial context will advance our understanding of intratumoral heterogeneity and how the complex interactions between cancer and surrounding no...
Astrocytes as the integrators of neuromodulator signals
This transformative award application is designed to test an integrative hypothesis about astrocyte function across the brain while extending the current limits of state-of-the-art...
Development of a novel, cost-effective gait training device utilized at home for the neurological patient population
Project Summary/Abstract In the U.S. over 5 million people are living with paralysis at an annual cost of over $200B to the healthcare industry, over half of which is due to stroke...
Development of preschool speech-to-print curricula with online gaming technology for early language development
PROJECT SUMMARY Children ages 2-6 are experiencing a steady decline in speech and language development rates. Lack of a developmentally appropriate preschool curriculum with techno...
Developing an Anti-proteotoxicity Therapy for Neurodegenerative Diseases
Project Summary Protein quality control is a fundamental system in the cell that is important for normal cellular functions and defense against potential pathogenic insults. Protei...
Advancing Commercial Readiness of a No-implant Interatrial Shunt Therapy to Treat Heart Failure
ABSTRACT Congestive heart failure (CHF) is a progressive condition that currently affects over 6 million patients in the US. It accounts for over $35B in annual healthcare expendit...
A novel, smartwatch-enabled, automated mobile heart rhythm analysis technology to start antiarrhythmic medications safely at home
ABSTRACT By 2030, more than 12 million Americans will suffer from atrial fibrillation (AF), a heart arrhythmia which dramatically increases mortality and risk of stroke. Class III...
Line extension and expanded preclinical evidence for Nerve Tape, a sutureless nerve repair coaptation device
Project Summary BioCircuit Technologies’ Nerve Tape® is a biologic wrap with integrated microhooks for sutureless repair of injured nerves. This SBIR Phase IIB project comprises ac...
Synergistic advancements in MR thermometry and predictive thermal modeling towards improved characterization of human brain temperature
Project Summary Brain temperature regulation is crucial for neurologic function and recovery after ischemia and injury. Local brain temperature increases as small as 1-2°C signific...
Advancing Visualization and Quantification of Subcellular and Biomolecular Mechanics through Mechanochemical Protocols
Project Summary Exploring cellular mechanics represents a groundbreaking frontier to unravel the complexities of life and disease. Far from being static entities, cells are dynamic...
Cranial Osteopathic Manipulative Medicine Enhances Brain Fluid Flow Alleviating Neuroinflammation
PROJECT SUMMARY/ABSTRACT Osteopathic manipulative medicine (OMM) has been used clinically to improve the quality of life for several medical conditions and injuries; however, limit...
Effectiveness of a Multilevel Rural Community Engagement Model for Improving Childrens Dietary Intake in Family Child Care Homes
PROJECT SUMMARY/ABSTRACT Early childhood is a formative period for establishing healthy dietary habits and weight trajectories, as such habits and weight predict later health outco...
Quantitative Ultrasound for Interstitial Lung Diseases
ABSTRACT The objective is to demonstrate feasibility of LQUS in human patients for assessing the severity of pulmonary edema due to heart failure and of idiopathic pulmonary fibros...
Pathways to Resilience of Social Networks of Older Adults with Advanced Cancer
Our study will address the goals of RFA-AG-24-025 by elucidating how the pathways by which key aspects of social connectedness in social networks (SNs)—structural characteristics,...
Pulsed laser therapy in an asymptomatic head injury-accelerated Alzheimer's model
Abstract Traumatic brain injury (TBI) is a significant cause of death and disability in the US. The true extent of TBI may be underestimated, with many cases of asymptomatic TBI go...