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606,025 grants found
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Center for Transformative Infectious Disease Research on Climate, Health and Equity in a Changing Environment (C-CHANGE)
Some of the greatest human health impacts from climate change are mediated by infectious diseases. Billions are at risk annually from malaria alone, and viral pathogen spillover ev...
Center for Transformative Infectious Disease Research on Climate, Health and Equity in a Changing Environment (C-CHANGE)
LEAD-MC SUMMARY The impact of climate change on human health via disease transmission remains a key need for study, even as other linkages between climate change and human health,...
Pacific Computational Genomics and Data Sciences Research Education Program
Project Summary/Abstract The overarching goal of this University of Hawaii Pacific CGDS Program is to support educational activities that encourage and promote diverse and underrep...
Integrating Maternal and Child Health Services: Development and Pilot Testing of a Pediatric Clinic-Based Postpartum Contraception Intervention
PROJECT SUMMARY/ABSTRACT While most postpartum women desire pregnancy prevention, fewer than half resume contraception in the postpartum period. Finding approaches to supporting wo...
Mechanistic understanding of host-microbe interactions in regulating stress response and lifespan
Summary/Abstract Host-microbe interaction plays a critical role in regulating the host’s nutrition, development, immune system, and aging. Whether it is the microbe or its host, bo...
Optimizing hematopoietic stem cell transplantation to treat non-malignant disease
Project Summary/Abstract This proposal outlines the five-year research and career development plans for the PI, Stephen P. Persaud, MD, PhD, who is preparing for a career as an aca...
Non-Contrast-Enhanced MRI for Brain Perfusion Mapping of Lewy Body Dementia
Project Abstract Cognitive impairment is a significant non-motor symptom of Parkinson's disease (PD). At least 75% of PD patients surviving for more than 10-years will develop...
Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia - The "NONO trial" - a pragmatic, multi-center, de-implementation, stepped-wedge, cluster-randomized trial
Project summary / abstract Congenital diaphragmatic hernia (CDH) is a complex congenital anomaly where an early embryologic insult disrupts diaphragmatic and pulmonary development,...
1/2 Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia - The "NONO trial" - a pragmatic, multi-center, de-implementation, stepped-wedge, cluster-randomized trial
Project summary / abstract Congenital diaphragmatic hernia (CDH) is a complex congenital anomaly where an early embryologic insult disrupts diaphragmatic and pulmonary development,...
Usage of Novel Linked Databases to Improve the Perioperative Management of Patients With Alzheimers Disease and Related Dementias
PROJECT SUMMARY AND ABSTRACT Many patients with Alzheimer’s Disease and Related Dementias (ADRD) undergo surgery. Indeed, patients with ADRD patients account for 25% of patients un...
From traditional medicine to innovation: Discovering novel analgesics targeting calcium modulation from Cameroonian phytochemicals
PROJECT SUMMARY/ABSTRACT There is a pressing need to identify and validate new targets for chronic pain and new sources for novel compounds. This proposal will use novel extracts a...
Dynamic changes in virome-host interactions during pregnancy and postpartum
Abstract For more than a decade the importance of the microbiome and its role in health and disease has been appreciated, yet the virome (the viral component of the microbiome) has...
ATP1A3-Related Disorders in Brazil: Natural History and Antisense Oligonucleotide Therapy Development
Project Summary ATP1A3-related disorders are a group of disorders caused by mutations in the ATP1A3 gene that encodes the α3 catalytic subunit of Na+/K+-ATPase transmembrane ion pu...
Functional characterization of viral-bacterial-human interactions during antimicrobial and inflammatory perturbations across different lifespans
ABSTRACT The gut microbiome (GM) strongly influences human health, playing critical roles in immune priming, nutrient metabolism, and pathogen exclusion. During infant and child de...
Integrative analysis of genomics and proteomics to identify candidate molecular transducers of cardiorespiratory fitness
Project Summary/Abstract: Cardiorespiratory fitness (CRF) is an integrative measure of cardiopulmonary and metabolic health, and a powerful, independent predictor of future risk of...
Localizing Therapeutics to Target Lung Myofibroblasts and Reverse Fibrosis
Project Summary/Abstract Lung diseases are a global public health problem with significant morbidity, inadequate therapies and a very high burden to society. Of these, idiopathic p...
Down Syndrome Early Childhood Omics, Deep Phenotyping, and Epidemiology in Texas: DECODE IT Cohort
ABSTRACT/SUMMARY Down syndrome (DS) is one of the most common genetic syndromes, with a birth prevalence of 1 in 700 that has been increasing in recent years. Children with DS enco...
Using Advanced Imaging to Improve Ex Vivo Lung Perfusion
ABSTRACT / SUMMARY While the number of lung transplantations performed worldwide is steadily growing every year, the number of viable donor lungs remains frustratingly small compar...
Whole Blood Point of Care Metabolic Measurement - SB1
PROJECT SUMMARY Persons of all ages with certain metabolic disorders are at-risk for metabolic crises when a certain metabolite accumulates in the blood. While this metabolite can...
Enhanced supercooling for extending non-freezing preservation in preclinical porcine and human donor livers
ABSTRACT. One in five liver patients on the transplant waitlist die before a new liver is found, while many more patients are never listed but could benefit from liver replacement....