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606,025 grants found
Showing 24,801 – 24,820 of 606,025 grants
Engineered cells as agents of arthritis therapy governed by artificial signaling
Project Summary Osteoarthritis (OA), a leading cause of years lost to disability worldwide, is characterized by the breakdown ofthe collagen II-rich matrix of articular cartilage,...
Improving Choice and Use of Biomedical HIV Prevention for Women in Uganda: A Couples-Based Approach
PROJECT SUMMARY/ABSTRACT The HIV prevention field has realized a long-sought goal to have multiple safe and effective HIV prevention options that offer women the opportunity to cho...
Estrogen-mediated effects on neutrophil function and airway inflammatory response
Project Summary Cystic Fibrosis (CF) and nonCF bronchiectasis (NCFB) are characterized by thickened respiratory secretions, chronic lung infection and neutrophilic inflammation. A...
A liver digital twin for personalized cancer therapy
Project Summary/ Abstract Our long-term objective is to improve the efficacy and safety of liver cancer transarterial embolization through new computational tools that enable the d...
Defining the Human Metabotype" [Human metabolic status defined through genetic, diet,environmental exposure and exercise perturbations]
PROJECT SUMMARY/ABSTRACT Molecular Transducers of Physical Activity (MoTrPAC), Nutrition for Precision Health (NPH), and the Human Health Exposure Analysis Resource (HHEAR) are NIH...
Enhancing and making Biomarker Knowledge FAIR using contextual CFDE data
The Common Fund (CF) research initiative has generated a wealth of data that can provide vital context, origin, and, in some instances, quantitative inferences for biomarkers. Howe...
UniProt Partnerships with Common Fund Data Ecosystem Resources for Protein-Centric Functional Genomics
PROJECT SUMMARY/ABSTRACT UniProt is one of the foundational resources for understanding the molecular details of the inner life of the cell. As a hub for knowledge of protein seque...
Manufacturable Biomimetic Microfluidic Oxygenator for Safer, Simpler Treatment of Respiratory Failure
PROJECT SUMMARY/ABSTRACT This Fast Track STTR project focuses on developing and demonstrating a high-volume manufacturing technology for microfluidic oxygenators for applications r...
Monitoring Immunotherapy Response via Gene Silencing Landscapes in Cell-Free DNA
ABSTRACT: Immunotherapies produce remarkable, long-term responses in subsets of patients with non-small cell lung cancer, but unfortunately, most patients do not respond to such tr...
The Alama Project: Autism outcomes and neurobehavioral markers in young children born to mothers with HIV in Kenya
PROJECT SUMMARY An estimated 14.8 million children – 90% of whom live in Africa – are HIV-exposed and uninfected (CHEU). Despite advances in understanding health outcomes of CHEU,...
Metabolic Health, Lifestyle, and Risk of Co-Occurring Health Conditions in Down Syndrome (MET-DS)
ABSTRACT Beginning early in life, metabolic dysregulation related to the triplication of chromosome 21(e.g. decreased energy expenditure, increased leptin, hypotonia, increased inf...
Advancing the Lives & HeaLth of Youth and Young Adults with Down Syndrome (ALLY-DS)
PROJECT SUMMARY Endocrinopathies, sleep disorders, cognitive issues, cardiovascular conditions, sensory impairments, and ability differences not only impact the quality of life of...
Evidence-based Parent Training for Diverse Families (PTDF)
Abstract Historically, bias in the U.S. has made it difficult for lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people to marry and form families. The situation is changi...
Hybrid Delivery to Increase Access and Sustainability: Evaluating ezParent Implementation
PROJECT SUMMARY/ABSTRACT Positive parenting practices (e.g., supportive, consistent, responsive) buffer the negative effects of early adverse experiences by developing safe, stable...
A Novel Device for Cervical Insufficiency in Pregnant Women
Abstract Cervical insufficiency is a severe complication of pregnancy that leads to preterm birth. Preterm birth is a significant cause of morbidity and mortality in newborns infan...
Atherosclerosis assay development for drug efficacy and cytotoxicity screening
Project Summary Cardiovascular disease, primarily driven by atherosclerosis, is the leading cause of death in the U.S. The recent FDA Modernization Act 2.0 allows the use of altern...
Stiffness measurements in human lung slices to evaluate therapeutic and preventive potentials of anti-fibrotic drugs
Abstract Idiopathic Pulmonary Fibrosis (IPF) is a rapidly progressing lung disease with no known cure. This therapeutic gap partly reflects the failure of current drug discovery te...
Platform technology to identify and develop first-in-class anti-fibrotic therapeutics through inhibition of collagen CP4H
Abstract There is a critical need to develop novel therapeutics to address underserved diseases which stem from abnormal fibrosis affecting multiple organ systems. Such diseases in...
Virtual PARTNER (Provide, Activate, Restore, Track, iNspire, Educate, Rehabilitate): Multi-component virtual reality application to target a reduction in delirium in the intensive care unit.
Project Summary Delirium commonly plagues patients in the hospital. Patients in the intensive care unit (ICU) have the highest risks for delirium, estimated to be between 70% to 80...
Leadless Pacemaker Betavoltaic Power Source
PROJECT SUMMARY Lithium-based batteries have reached a technological limit of ~0.6 cc for use in leadless cardiac pacemaker (LCP) applications and a useful life of only 7-10 years1...