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Non-invasive exfoliome platform to accelerate treatment for gastrointestinal disorders
SUMMARY Inflammatory Bowel Disease (IBD), composed of Crohn’s disease (CD) and ulcerative colitis (UC), is the most common chronic inflammatory condition of the gastrointestinal (G...
A scalable intervention for stress management practices
Roughly 60% of college students meet the criteria for at least one mental health disorder, with anxiety and depression being the most common diagnoses. The number of students seeki...
Determining the Mechanisms of RING1- and YY1-binding protein (RYBP) function and dysregulation in glioblastoma cells
PROJECT SUMMARY / ABSTRACT Glioblastoma multiforme (GBM) is the most common and most lethal tumor of the central nervous system, with a median survival of less than 15 months (Stup...
Lifespan and Cardiovascular Health Effects on The Brain in Humans and Great Ape
Project Summary Humans and great apes share many similarities in age-related illnesses including cardiovascular and cerebrovascular diseases. Nevertheless, critical differences exi...
Examining the Role of Allostatic Load and Neighborhood Disadvantage in Cognitive Function Trajectories among Midlife and Older Black Americans
Project Summary Black Americans are twice as likely to develop Alzheimer’s disease (AD) than White Americans. The biopsychosocial determinants of cognitive function, an early-stage...
Physiological and Behavioral Basis of Circadian Rhythm Delayed Sleep-Wake Phase Disorder
PROJECT SUMMARY/ABSTRACT Delayed Sleep Wake Phase Disorder (DSWPD) is a common circadian rhythm sleep-wake disorder that is characterized by difficulty in initiating sleep at night...
Formative Implementation Research on Translating Evidence to Hospital Care for People Living With Sickle Cell Disease (FIRES)
PROJECT SUMMARY This is an application for a K23 Mentored Career Development Award for Dr. Ashley Jenkins, a dually trained Internal Medicine and Pediatrics (Med-Peds) hospitalist....
Studies on G-protein coupled receptors that are activated by neuroactive steroids
Abstract. Neuroactive steroids (NAS) such as allopregnanolone (ALLO) are synthesized in the brain from progesterone (P4) and exert potent anxiolytic, anticonvulsant, antidepressant...
1/7-PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...
COMBINI: connecting COmplementary Medicine evidence and BIological kNowledge to support Integrative Health
Project Summary Complementary medicine (CM) approaches are increasingly used by health care consumers, accepted by the medical community, and viewed as a cornerstone of whole perso...
Assessment of germline variants associated with immune-related adverse events following immune checkpoint inhibitors
PROJECT SUMMARY Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but come with the significant downside of immune-related adverse events (irAEs), which can...
Comprehensive Maps of Early Spliceosome and Regulator Binding to Nascent RNA in Human Cells
PROJECT SUMMARY/ABSTRACT We propose to develop new methods for the global identification of protein and RNP interactions with nascent unspliced RNA in human cells. We will use thes...
Integrated Care Plans and Health Care Quality, Outcomes, and Equity for Medicare-Medicaid Dual Eligible Beneficiaries with Multimorbidity, Frailty, or Dementia
PROJECT SUMMARY / ABSTRACT Integrating coverage for dually eligible Medicare-Medicaid beneficiaries (‘duals’), a population with complex medical and social needs, is a national pri...
Rapireon, a new macrocycle molecular glue that selectively activates the nuclease activity of IRE1
The unfolded protein response (UPR) pathway plays an essential role in health and diseases from cancer to neurodegeneration. Of the three UPR pathway branches, the IRE1-XBP1 pathwa...
Evaluating the Impact of Non-COPD Medications on COPD Management
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. While numerous scientific advances have been made to improve the care of patie...
Miniature Selective Plane Illumination Fluorescence Microscope for High-resolution Volumetric Imaging in Freely Behaving Mice
An important theme in system neuroscience is to understand the fundamental principle by which brain cells work together to give rise to behaviors. Neuroscience experiments often re...
Dementia and the opioid epidemic: The impact of the 2016 CDC guidelines on disparities in pain management
PROJECT SUMMARY/ABSTRACT The research proposed in this application aims to study the impact of the publication of the 2016 Centers for Disease Control and Prevention (CDC) analgesi...
Sleep pathology and cardiac aging
PROJECT SUMMARY/ABSTRACT Sleep is normally a period of biological rest and recuperation for the cardiovascular system. Inadequate or low- quality sleep is known to increase the ris...
Optimizing the Daily Care Interactions Between Direct Care Staff and Assisted Living Residents with Dementia
PROJECT SUMMARY About 25% of daily care interactions between staff and residents in long-term care including Assisted Living Facilities (ALFs) comprise of poor care interactions. I...
Illuminating associations between parent's adverse childhood experiences, children's obesity, and neighborhood environment
SUMMARY Adverse childhood experiences (ACEs) can increase the risk for obesity both during childhood and later in adulthood. Emerging evidence suggests a parent's history of A...