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EduWell: Education for Health and Learning
The overall purpose of the researchnetwork EduWell is to explore, explain, compare and develop school health education in Sweden, Finland, Norway and Iceland. Young people´s mental...
Tumor microenvironment biomechanics studied with microscale acoustofluidics
We aim to investigate, modify and quantify biomechanical properties in tumor-on-a-chip spheroids and organoids, focusing on the cellular and sub-cellular length scale within the tu...
Brightening the Universe: New Directions for Astrophysical Axion Searches
The nature of dark matter and what lies beyond the Standard Model (SM) of particle physics are among the most profound unanswered questions in fundamental physics.We propose a pion...
Precision treatment of type 2 diabetes based on the beta-cell phenotype
What defines the dysfunction of the insulin-secreting beta-cells in type-2 diabetes (T2D)? This question is central to the understanding of the causes, treatment and prevention of...
CD69 PET of activated immune cells in immunotherapy
The advent of immunotherapy has revolutionized cancer treatment, yet its effectiveness varies widely among patients, underscoring the need for better diagnostic tools to guide ther...
Mechanisms of plasmid copy number control in bacterial pathogenesis and antibiotic resistance
Plasmids often encode virulence determinants and multi-antibiotic resistance.Previously, we established that up-regulation of plasmid copy number (PCN) is an essential virulence me...
Optimization of the management and timing of surgery of patients with bicuspid aortic valve stenosis to prevent complications
Stenosis of the aortic valve is the most common valvular disorder in the western world.The bicuspid aortic valve (BAV), where the aortic valve have two instead of three leaflets, i...
Mapping context sensitive properties of Kv channels to improve selective drug design
Current treatments do not provide sufficient relief for up to 30% of those suffering from excitability conditions such as cardiac arrhythmias and epilepsy.Voltage-gated potassium (...
Regulation of Memory B cells During Vaccination
Vaccines are still lacking against genetically variable pathogens including HIV-1 and hepatitis C virus, and potent vaccines are also lacking against other viral pathogens includin...
Targeting dysregulated basal ganglia output in Parkinson’s disease.
The motor symptoms of Parkinson’s disease (PD) originate from dysfunctions in the basal ganglia, triggered by a reduction in dopaminergic tone. Dopaminergic therapy is effective in...
Why must I feel sick? The benefits of sickness behavior in the defense against pathogens
Everyone has experienced sickness behavior during an infection: feeling fatigued, having little appetite, wishing to stay alone, lacking motivation, and maybe even feeling depresse...
Synaptic connectome maladaptation in the circuits of innate fear
Mental disorders account for 30% of the global disease burden. Anxiety disorders represent the highest proportion with conditions such as post-traumatic stress disorder (PTSD). Wom...
Flavor and CP from beyond the electroweak scale
This project aims to develop extensions of the Standard Model of particle physics based on strongly coupled gauge theories, positing the Higgs boson as a composite particle.Buildin...
Harnessing genomic plasticity and functional potential to assess fitness of human gut bacteria strains
Our gut microbes have evolved alongside us, adapting to changes in diet, lifestyle, and environment over time.Consequently, they continuously generate new lineages, some of which e...
A CRISPR approach to develop pro-oxidant therapies for lung cancer
Lung cancer is one of the most common cancer forms with poor prognosis for patients with advanced disease.Evidence from our group and others suggest that lung cancer cells are dama...
PLOTTING THE DEVELOPMENT OF AUTOREACTIVE B CELLS IN AUTOIMMUNE DISEASE
Autoimmune diseases affect more than 5% of the world’s population. They are often debilitating and chronic, posing significant challenges to patients and Society. For many of these...
Geohash Barcoding: a novel single cell spatial toolbox to decipher malignancy through epigenetic regulation and genome instability crosstalk with the tumor microenvironment
Nonmutational epigenetic reprogramming and genome instability are two important hallmarks of cancer.To fully comprehend malignancy, it is essential to determine how these two hallm...
Unraveling tissue microenvironment dynamics in the pathogenesis of Group A Streptococcal necrotizing soft tissue infections
Necrotizing soft tissue infections (NSTI) are life-threatening infections mainly caused by Group A Streptococcus (GAS). GAS NSTI tend to affect younger, healthy individuals, often...
The Polymorphic Red Blood Cell Surface: For Safer Transfusions and a Role as Regulator of Hematopoiesis, Host-Pathogen Interactions and Hemostasis
Red blood cells (RBCs) constitute >80% of our cells and 118 million blood donations/year are used by healthcare globally. All need to be matched between donor and patient. T...
Deciphering the molecular mechanisms underlying human evolutionary adaptation to hypoxia
Multicellular organisms critically rely on systems such as red blood cell production (erythropoiesis) to sense oxygen availability and ensure a continuous systemic supply.Yet, the...