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606,025 grants found
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Building subject knowledge in texts. Subject-specific knowledge practices in humanities subjects in upper secondary school writing
The purpose of the project is to explore what distinguishes written knowledge practices within disciplinary student texts in humanities subjects in upper secondary school, if and h...
Studies in islets and enteroendocrine cells to identify targets for the treatment of T2D
Type 2 diabetes (T2D) is a global health problem and there is a need for improved therapies.Perturbed islet function is the main cause of T2D, but the processes that fail in ea...
Cytoprotection by metacaspases: molecular mechanisms and biological implications
All organisms have specialized proteins that can either kill the cells or grant them survival under stress.Surprisingly, proteins originally known as dedicated cell killers may, de...
Tailoring metal-organic frameworks to 3D print green water harvesting units that do not require electricity input (3D-HarvesterMOFs)
Current atmospheric water (AW) harvesting technologies, primarily designed for arid conditions, only permit one harvesting cycle daily without electricity.We intend to pioneer the...
Morpho-synthetic continua with long range spatial dependence as energy harvesting materials
This project aims to develop a comprehensive quantitative theory of coupled fields with long-range spatial dependence, leveraging thermodynamics to deduce constitutive laws across...
A precision medicine approach to understand the complexity of insulin resistance
Insulin resistance is a critical factor in the pathogenesis of type 2 diabetes and cardiovascular diseases, yet the underlying cellular mechanisms remain inadequately understood.We...
The cholesterol-CYP46A1 axis: a promising therapeutic target to protect women at risk of Alzheimer’s disease.
Women account for two-thirds of individuals suffering from Alzheimer’s Disease (AD). Women with early menopause and those carrying the APOE4 gene are at higher risk for AD.Menopaus...
Advancing precision radiotherapy through novel cancer targeting strategies
This project aims to explore and potentiate molecular radiotherapy of cancer, where cancer-targeting molecules are equipped with radionuclides to enable cancer-specific imaging and...
ON PRESENT AND NOVEL TREATMENTS FOR DEPRESSION
We aim to shed further light on established antidepressants and to pursue a possible new treatment for difficult-to-treat cases.Subproject 1: In item-based, patient-level analyses...
Mutation rates as life history traits
Mutation is the source of genetic variation, and the rate at which mutations occur influences a wide range of evolutionary phenomena. Understanding the factors that shape the mutat...
Kinetic modelling and spatially resolved chemical analysis to explore dose-at-target during early development (DOSEARLY)
This project aims at developing and validating computational models for assessing exposure of organic pollutants during critical developmental stages in vital target tissues of zeb...
The early sequestered germline of basidiomycete fungi – spatial distribution, mechanism and generality across the kingdom
The purpose of this project is to investigate how the germline is determined in basidiomycete fungi.Already in the late 1800s, August Weismann proposed that only germ cells carry h...
The Dirichlet problem and boundary regularity for local and nonlocal nonlinear elliptic equations in metric spaces
In this project we will study the Dirichlet problem and boundary regularity for elliptic equations in R^n and metric spaces in three different settings. I. For nonlinear 2nd order...
Nordic Research Network on Teaching and Learning in Innovative Learning Environments
The Nordic Network on Research in Innovative Learning Environments (NNILE) comprises four research groups from four key institutions: Umeå University, Norwegian University of Scien...
Molecular movies of large non-coding RNAs assembling into functionally-active 3D structures
Many non-coding RNAs (ncRNAs) rely on three-dimensional (3D) structures to perform their cellular functions, but the underlying mechanisms by which RNAs acquire 3D structures are s...
Mountains in a warming world: biotic refugia or elevators to extinction?
While no palaeoclimate is a perfect equivalent for future climate scenarios, the geobiological record is our only observational precedent for how ecosystems may respond in a rapidl...
Timing many-body effects in atomic systems
Light-sources based on the process of High-Harmonic Generations provide now increased repetition rates, as well as photon energies approaching the soft-X-ray region, at the same ti...
Racism and anti-racism in elementary school - A study on how everyday racism emerge and is challenged in different school contexts
The purpose of the project is to contribute with knowledge about how everyday racism emerge and is challenged in elementary school in Sweden. Racism is a part of many students´ eve...
New Strategies for Studying Neuroinflammation in the Living Human Brain using Positron Emission Tomography
This project seeks to advance the use of Positron Emission Tomography (PET) for studying neuroinflammation (NI). PET enables quantification of molecular targets of NI both during d...
Clonal analysis reveals epigenetic drivers of craniofacial birth defects
During embryogenesis, mesenchymal stem cells regulate cell division rates and cell differentiation in order to properly form skeletal elements like cartilage and bone, but how this...