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Exploring molecular mechanisms by which microbially produced metabolites protect against or promote type 2 diabetes
Type 2 diabetes (T2D) is a common condition of diverse aetiologies diagnosed by high blood glucose levels. Over the past 20-years it has become evident that the gut microbiota is a...
Dynamics of thin-film equations
Thin liquid films are omnipresent in nature, daily life, and industrial processes, with extensive use in various coating teachniques such as spin coating, responsive coating and bi...
Interprofessional Coaching to Enhance Language and Learning in Secondary Classrooms Using Digital Education for Teachers (INCLUDE)
INCLUDE aims to enhance learning and participation in secondary classrooms through a digital teacher professional development program called LINK-D, where teachers get techniques t...
Accelerating sparse linear algebra with graph neural networks
We aim to accelerate sparse linear algebra by harnessing the power of machine learning, specifically graph neural networks (GNNs).Sparse linear algebra is pivotal in solving large-...
Goblet cells as regulators of colonic immunity: implications for the pathogenesis of colitis
Ulcerative colitis (UC) is a chronic disease with unknown etiology.The current understanding of UC is that the inflammation targets gut bacteria, but detailed understanding of why...
Dissecting tissue resident lymphocyte homeostasis in human cancer
Natural killer (NK) cells play a crucial role as early immune effectors in the defense against cancer, existing both in peripheral blood and as tissue-resident (TR) cells in human...
Invasion Frontiers in Liver Metastases: From Cellular Processes to Novel Therapeutic Strategies
Metastases are the main cause of cancer mortality.In liver metastases, prognosis depends on the histological pattern of the invasion front: Extensive tumor-hepatocyte contact is li...
Defining the role of antioxidants and BACH1 in tumor angiogenesis and metastasis
Our group discovered that antioxidant supplementation of the diet accelerates cancer progression and metastasis and that this effect is partly mediated by the redox-sensitive trans...
Stress-induced chromatin remodelling in health and disease
The human genome´s accessibility is tightly controlled by its organisation into chromatin.Cellular stresses, like DNA damage and protein misfolding, trigger transient chromatin rem...
Neural circuits in semaglutide-induced weight loss
Semaglutide is a long-acting GLP-1 analogue that has revolutionized the treatment of obesity, but its brain-mediated mechanisms are unclear. The overarching goal of my research is...
Deciphering macrophage- and stem cell-driven adipose tissue remodeling as a means to treat and prevent metabolic diseases
Obesity and polycystic ovary syndrome (PCOS), a hyperandrogenism condition affecting women, are often associated with adipose tissue dysfunction, leading to ectopic lipid depositio...
Identifying ligands for the activating NK cell receptor NKp46
Natural killer (NK) cells are innate effector cells that participate in defense against viral infections and malignancies. The cytotoxicity of NK cells is regulated by a battery of...
Spatial biology of membrane proteins
Most drugs in clinical use target membrane proteins.Accumulating evidence shows that most membrane proteins are not uniformly distributed but localize to dynamic domains of nanosca...
Regeneration of the dorsal column tract in chronic spinal cord injury.
Spinal cord injuries pose significant challenges as there are currently no effective therapeutic interventions available, leading to irreversible functional deficits.While peripher...
PROTACs - A novel strategy for the treatment of Alzheimer disease
The presence of β-amyloid plaques and neurofibrillary tangles of tau are two main pathological hallmarks of Alzheimer disease (AD).Lowered efficiency of degradation pathways, such...
CAL Sub-phenotypes: A Systems Medicine Framework for Investigating Molecularly & Mechanistically Distinct Groups with Chronic Airflow Limitations (CAL) in Never-smokers
Chronic airflow limitations (CAL), which includes Chronic obstructive pulmonary disease (COPD), is a global health problem affecting 10% of the population, 20% of which have never...
Astrocytes: a potential target to reduce cell-to-cell spreading and chronic inflammation in Alzheimer’s disease
Decades of research have focused on neuronal abnormalities during Alzheimer’s disease (AD) progression, while glial cells, including astrocytes, have been given much less attention...
Exploring therapeutic opportunities in the recurrent brain tumor microenvironment
Gliomas are the most common primary brain tumors and the highest-grade glioma, glioblastoma (GBM), is arguably the most aggressive tumor type, with virtually no long-term survivors...
Testosterone regulation of human immunity
Immune-mediated diseases exhibit marked sex bias.Although men present with more severe infections and have lower vaccine responses, treatment strategies still neglect biological se...
Needs-based school funding - a path to improving student achievement and reducing educational inequalities?
The project will study the effects of needs-based school funding on students’ educational paths, using hand-collected data from all Swedish municipalities and comprehensive, high-q...