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Translational studies on SAMHD1 as resistance factor, tumour suppressor, and regulator of immune responses
Our overarching goal is to rationally improve cancer treatments.To this end, we study the key cancer protein SAMHD1 that has context-dependent roles for treatment resistance, tumou...
Psychobiological markers to improve diagnosis and to predict affective episodes in bipolar disorder
There is an urgent need for better tools to improve and facilitate diagnosis of bipolar disorder and to detect and prevent affective episodes at the earliest possible stage.We hypo...
Innovative biomaterials and methods targeting corneal blindness
The cornea is the eye´s outermost transparent window, and maintenance of its transparency and shape are essential for vision.Degenerative, age-related and uncorrected refractive ch...
Den genetiska grunden för överföring av malariaparasiter: förstå oocystans kritiska roll.
The transmission of Plasmodium parasites by mosquitoes is a major target to reduce the global burden of malaria. It relies on the coordinated developmental cycles of mosquito repro...
Reduction and refinement of mouse usage with in utero engineered mouse models
Genetically engineered mice are the current state of the art for understanding gene function, lineage tracing studies, and more.However, these mouse models entail by-production of...
Optimizing outcome and improving accessibility to psychological treatment for adolescent self-injury: randomized controlled trial
Self-injury is a growing health crisis among youth, and the strongest risk factor for suicide attempts. Scalable treatments are needed but lacking.We have recently shown that a bri...
Next generation vascular targeting for brain tumors
Glioblastomas are aggressive gliomas characterised by an extreme invasiveness and dysfunctional vessels.The abnormal vessels promote tumor progression (1) by providing a route of i...
Epidemiological and single-cell transcriptomic studies on the effects of vitamin A and inflammation on bone health
The overall aims of this project is to understand how vitamin A and inflammatory processes affect bone mass.Increased levels of vitamin A are considered a risk factor for secondary...
Boosting the Intestinal Mucosal Barrier to Emerging Pathobionts in Patients with Crohn´s Disease
Crohn´s disease (CD) is one of the main chronic inflammatory bowel diseases, with significant impacts on patients´ quality of life.Current treatments lack therapeutic precision, co...
The paths of MS – data-driven personalized prediction of multiple sclerosis risk and disease-modifying treatment outcomes
Multiple sclerosis (MS), a chronic inflammatory and neurodegenerative condition, is a major driver of disability and healthcare costs among young to middle-aged adults.Access to di...
GLP-1 Receptor Agonists and Other Pharmacotherapy for Type 2 Diabetes and Obesity: Use and Safety in Pregnancy
Semaglutide and other GLP-1 receptor agonists (GLP-1 RA) have revolutionized the treatment of type 2 diabetes and obesity and their use in Sweden and globally has increased dramati...
TeamBirth and intervention to improve patient safety and person-centered care during childbirth
Most adverse events within maternity care stem from communication and teamwork failures.Despite national and international recommendations, few interventions include person-centere...
Remaining pain in rheumatoid arthritis – Therapeutic performance of different biological treatments and clinical relevance of a recently identified unexplored causative signalling pathway.
Pain in rheumatoid arthritis (RA) is highly debilitating, impacts quality of life and lacks adequate treatment options.Although biologics have proven benefits on inflammatory disea...
Study the targetome structures of OncomiR 34a to reveal the regulatory mechanism
MicroRNAs (miRs) are dysregulated in over half of all cancers and numerous other diseases.The efficiency of miRs´ regulation is primarily predicted based upon a 6-8 nucleotide base...
Chromosome-wide gene regulation, aneuploidies and chromosome segregation
Aneuploidy, characterized by the loss or duplication of entire chromosomes or chromosomal segments, often compromises overall fitness, and confers proliferative disadvantages.Despi...
To Understand and Predict the Impacts of Warming Climates on Plastics: Accelerated Degradation and Environmental Implications (WarmPlastix)
Global warming is intensifying, as seen in the extreme heatwaves of 2022 and 2023, leading to significant consequences like increased mortality and rampant wildfires.With these eve...
Vibrational Control in Organic Semiconductors
Organic semiconductors (OSCs) are carbon-based materials with great potential for photovoltaic (OPV) and light-emitting diode (OLED) applications.This project will improve our unde...
Hubble trouble: A new measure of the universal expansion using lensed supernovae
Modern cosmology can explain the evolution of the Universe using only six parameters, typically determined with sub-percent accuracy.They include the amount of dark matter, necessa...
Development and evaluation of the PeriBrainCare Bundle- a complex health intervention to support older persons in their neurocognitive recovery after cardiac surgery (ECPON part 2)
The number of older people who undergo complex surgical procedures continues to rise.Old age is a significant risk factor for the development of postoperative neurocognitive declin...
Apoptosis and efferocytosis as mechanisms of impaired fibrotic tissue repair in diabetes associated vascular complications
Individuals with type 2 diabetes (T2D) die prematurely due to cardiovascular complications caused by an aggravated arterial atherosclerotic plaque formation.We provided evidence fo...