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Showing 34,50134,520 of 606,025 grants

Active NON-SBIR/STTR RPGS
Using Virtual Reality to help develop discrepancy and elicit change talk in brief motivational interventions for heavy drinking young adults
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM Brown University United States 2024 – 2029

Project Summary/Abstract Alcohol use is the leading risk factor for premature death among young adults globally. Brief motivational interventions (BMIs) can help young adults reduc...

$6.19M
USD
Active TRAINING, INSTITUTIONAL
Alcohol Prevention Research on Violence, Equity, and Novel Techniques (A-PREVENT) Training Program
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM Georgia State University United States 2024 – 2029

PROJECT ABSTRACT Alcohol misuse is a significant public health issue leading to serious consequences including alcohol use disorder and numerous alcohol-related morbidities. Resear...

$2.09M
USD
Active NON-SBIR/STTR RPGS
Microphysiological joint-on-chip platform for the study of arthritic diseases
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETA... University of Colorado United States 2024 – 2029

PROJECT SUMMARY / ABSTRACT The objective of this proposal is to establish a new microphysiological ‘joint-on-chip’ system, with structural biomimicry and biomechanical function, th...

$6.19M
USD
Completed OTHERS
Heal(th) From Within: A Research Collaborative to Share our Journeys to Wellness
NATIONAL INSTITUTE ON DRUG ABUSE Alaska Native Tribal Health Consortium United States 2024 – 2025

Abstract Alaska Native Tribal Health Consortium’s (ANTHC) vision is that Alaska Native people are the healthiest people in the world. Alaska is homeland to an estimated 151,405 Ala...

$5.43M
USD
Active NON-SBIR/STTR RPGS
Autism Spectrum Disorders and Auditory System Deficits: Role of Neuronal and Immune System Dysfunction
NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICA... Medical University of South Carolina United States 2024 – 2029

ABSTRACT Hearing impairment in children with autism spectrum disorders (ASDs) may contribute to core ASD symptoms by interfering with language development and communication. The nu...

$6.42M
USD
Active NON-SBIR/STTR RPGS
Implementation of Neuromuscular Electrical Stimulation after Total Knee Arthroplasty
NATIONAL INSTITUTE ON AGING University of Colorado Denver United States 2024 – 2029

PROJECT SUMMARY / ABSTRACT Total Knee Arthroplasty (TKA) reduces pain and disability caused by knee osteoarthritis, but the surgery results in substantial trauma to the knee. This...

$10.23M
USD
Active NON-SBIR/STTR RPGS
Study of Biological and Radiographic Biomarkers and Association with Ancestry and Survival Disparities in Oral Cavity Squamous Cell Carcinoma Using AI Approaches
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEAR... University of Maryland Baltimore United States 2024 – 2029

ABSTRACT Oral cavity squamous cell carcinoma (OSCC) is a complex and aggressive disease that requires multidisciplinary care and has a poor prognosis at advanced stages. Moreover,...

$6.6M
USD
Active OTHER RESEARCH-RELATED
Creating and disseminating resources for the genomics and omics of behavioral and social phenotypes
NATIONAL INSTITUTE ON AGING University of California Los Angeles United States 2024 – 2029

Project Summary/Abstract This proposal is an R24 research network application. The Social Science Genetic Association Consortium (SSGAC) is a research network that provides a platf...

$4.07M
USD
Active NON-SBIR/STTR RPGS
Natural history and validation of surrogate biomarkers and patient-reported outcomes for SJIA-LD
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETA... Cincinnati Childrens Hosp Med Ctr United States 2024 – 2028

Project Summary / Abstract Chronic lung disease in children with systemic juvenile idiopathic arthritis (SJIA-LD) is a life-threatening disorder which is increasing in incidence an...

$2.06M
USD
Completed NON-SBIR/STTR RPGS
Neurological Disorders in HIV-1 Infection
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND S... University of Nebraska Medical Center United States 2024 – 2026

ABSTRACT There is a high incidence of neurological disorders (HAND) in middle-aged people living with HIV infection (PLWH). To date, the molecular causes for diverse array of HAND...

$2.3M
USD
Active NON-SBIR/STTR RPGS
Innovative Tools to Expand HIV Self-Testing and Long-Acting Injectables for HIV Treatment and Prevention Among Commercial Minibus Drivers (I-TEST LAIs)
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEA... George Washington University United States 2024 – 2029

Abstract: Commercial minibus drivers constitute a large social network of highly mobile men who work long and demanding hours, are at increased risk for HIV, and have limited time...

$8.1M
USD
Active NON-SBIR/STTR RPGS
AmbassADDOrs for Health: Maintaining youth-friendly HIV prevention services to young women through drug vendors
NATIONAL INSTITUTE OF MENTAL HEALTH University of California, San Francisco United States 2024 – 2029

SUMMARY Adolescent girls and young women (AGYW; ages 15-24) in sub-Saharan Africa face the dual threats of HIV infection and unintended pregnancy that severely undermine their long...

$7.08M
USD
Active NON-SBIR/STTR RPGS
Optimizing mobile interventions to overcome stigma and promote HIV prevention among Thai young transgender women
NATIONAL INSTITUTE OF MENTAL HEALTH University of Massachusetts Med Sch Worc... United States 2024 – 2027

Transgender women (TGW), particularly young TGW (ages 18-29), are among the fastest growing HIV+ populations worldwide, with HIV prevalence rates of 15-28%. Thailand has the highes...

$6.64M
USD
Completed NON-SBIR/STTR RPGS
CHAMPION - Combining HIV And Stimulant Prevention and Treatment Interventions Optimized for HIV-Negative MSM
NATIONAL INSTITUTE ON DRUG ABUSE University of California, San Diego United States 2024 – 2026

PROJECT SUMMARY MSM remain disparately impacted by HIV, with only 35% of US MSM with indications for PrEP having ever used PrEP. Meth use is an established and persistent driver of...

$2.02M
USD
Active NON-SBIR/STTR RPGS
SCH: Multi-modal Biosensing and Predictive Analytics for Continuous Monitoring of Mobility and Cognition in an Aging Population
NATIONAL INSTITUTE ON AGING Tufts University Medford United States 2024 – 2028

PROJECT SUMMARY (See instructions): Declines in cognitive and motor function are early harbingers of pending Alzheimer's Disease and related dementia (AD/ADRD). New technologi...

$2.69M
USD
Active TRAINING, INDIVIDUAL
Influence of early exposure to bitter foods on bitter taste sensitivity in adulthood
NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICA... State University of New York At Buffalo United States 2024 – 2026

Project Summary Vegetable intake can contribute to many health benefits; however, the bitter taste of vegetables creates a barrier to consuming a healthful diet. Therefore, to incr...

$338.3K
USD
Active NON-SBIR/STTR RPGS
Molecular mechanisms controlling skin heterogeneity
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETA... Icahn School of Medicine At Mount Sinai United States 2024 – 2027

This project summary pertains to the Supplement. Different regions of the skin vary in their characteristics such as thickness, pigmentation, innervation, and presence, size and de...

$1.02M
USD
Completed NON-SBIR/STTR RPGS
Preclinical Assessment of a Compliance Matched Biopolymer Vascular Graft - Diversity Supplement
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE University of Pittsburgh At Pittsburgh United States 2024 – 2025

PROJECT ABSTRACT Cardiovascular diseases (CVDs) stand as the primary contributor to global mortality and play a significant role in diminishing the quality of life. The growing inc...

$315.7K
USD
Completed NON-SBIR/STTR RPGS
RUNX3 in Vascular Wall Remodeling-Diversity Supplements
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE University of Texas Hlth Ctr At Tyler United States 2024 – 2025

Project Summary Vascular smooth muscle cell (VSMC) phenotypic modulation, a phenotypic switch from a differentiated contractile phenotype to a proliferative phenotype, contributes...

$425.1K
USD
Active NON-SBIR/STTR RPGS
Corticolimbic circuitry in adaptive stress coping behavior and subsequent alcohol drinking
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM University of New Mexico United States 2024 – 2027

Project Summary Individuals with post-traumatic stress disorder (PTSD) consume alcohol as an attempt to alleviate symptoms, which can increase the risk of developing a drinking pro...

$2.49M
USD