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606,025 grants found
Showing 34,361 – 34,380 of 606,025 grants
Engaging African American Couples in the Management of Obstructive Sleep Apnea
ABSTRACT Obstructive sleep apnea (OSA) affects 26% of adults over age 30 and is associated with significant morbidity and mortality. At the time of presentation, African American h...
Mitochondria in eosinophilic esophagitis pathogenesis
Project Summary Eosinophilic esophagitis (EoE) is a chronic food allergen- and immune-mediated disease that exerts a significant clinical and financial burden worldwide. Interleuki...
Investigating Mechanisms of Complement Mediated Synaptic Removal
Project Summary Alzheimer’s disease (AD) is a neurodegenerative disorder that culminates in neurodegeneration resulting in cognitive decline. The pathological correlate most tightl...
Explore the involvement of tRNA in the pathophysiology of antisynthetase syndrome
Project Summary Antisynthetase syndrome (ASSD) is a chronic autoimmune disorder characterized by myositis and interstitial lung disease (ILD). A key feature of ASSD is the presence...
A Pilot Study of Digital Sleep Optimization for Brain Health Outcomes in Older Surgical Patients (SLEEP-BOOST)
PROJECT SUMMARY/ABSTRACT Sleep disorders, including insomnia, are likely present in up to a third of older patients before surgery, but most remain untreated. Increasing evidence s...
Epigenetic deregulation of osteoblasts promotes age related clonality in hematopoietic cells
Abstract The bone marrow stroma and especially osteoblasts, are critical regulators of the development of hematological myeloid malignancies, actively promoting their development o...
BRAIN CONNECTS: A Scalable Automated Proofreading Framework for Connectomics
Summary Generating synapse-resolution maps or connectomes of the brain are crucial to understanding the neural basis of behavior, and can provide key insights into the onset, progr...
Homeostatic modeling of functional neuroimaging data in humans: a novel methodology to obtain brain maps of tissue pCO2, pO2 and pH in aging
Project Summary Altered cerebrovascular health is strongly associated with aging. PET and MRI studies have found age dependent reductions in resting cerebral blood flow (CBF) and n...
Gpr68 modulation of myofibroblast dynamics during tendon healing
Following injury, tendon heals via a fibrotic scar-mediated process. This fibrotic response impairs restoration of tendon structure and function, and there are currently no pharmac...
Impact of insecticide control measures and temperature on Dengue Virus transmission by Aedes aegypti mosquitoes
Project Summary Dengue is a human disease caused by the dengue virus (DENV) and transmitted by Aedes aegypti and Aedes albopictus mosquitoes that afflicts hundreds of millions of h...
Identifying non-human primate models for specific human microbiome traits
Abstract: The gut microbiota is increasingly recognized as an important contributor to a range of human physiological processes and is attracting increasing attention as a dynamic...
Revealing the mechanisms of increased intestinal epithelial cell barrier permeability in peanut allergy
PROJECT SUMMARY/ABSTRACT This proposal represents a five-year research career development program focused on understanding intestinal epithelial cell (IEC) barrier dysfunction in p...
Roles of epidermal integrin α3β1 in age-dependent changes during cutaneous wound healing
Project Summary Even without comorbidities associated with aging, wound healing in healthy elderly people (>65) is delayed, posing a high risk of infection. However, mechanisms...
Development of an Organoid-Derived Exosome Product for the Treatment of Osteoarthritis
Summary/Abstract Osteoarthritis (OA) is a chronic debilitating joint disease, affecting over 32 million people in the USA with an economic impact of $550 billion/year. OA is charac...
Small molecule stimulation of lubricin for treatment of post-traumatic osteoarthritis
Project Summary/Abstract The prevalence and cost of osteoarthritis is astounding, with total osteoarthritis-attributable medical expenditures and lost earnings surpassing $300 bill...
Understanding Pain Expression in Wabanaki People during Recovery: Enhancing Wabanaki Research, Data Self-Determination, and Capacity Development
This project aims to empower Wabanaki communities by enhancing their research and data capabilities through the increased capacity of REDCap, a HIPAA compliant, web-based data capt...
Care for Persons with Dementia in Medicare Advantage and Traditional Medicare: Family Spillovers and Disparities
Project Summary Medicare beneficiaries with Alzheimer's Disease and Related Dementias (ADRD) typically require significant amounts of formal and informal healthcare. These tre...
Sensory Aging, Late-Life Wellbeing, and ADRD Research Infrastructure to Catalyze Practice and Policy
ABSTRACT The goal of this 5-year research infrastructure development grant (R61/R33) is to substantially strengthen a small but successful collaborative, international network – th...
Promoting Community Wellbeing Through Indigenous Science and Healing
ABSTRACT American Indian and Alaska Native (AI/AN) communities have been disproportionately negatively impacted by opioid and stimulant drugs, health conditions that cause chronic...
Building iCRISP: Indigenous Community-Informed Research Infrastructure to address Substance Misuse and Pain Management
The Lumbee tribe of North Carolina is a state-recognized tribe of approximately 60,000 enrolledmembers, making it the largest American Indian tribe in the eastern United States and...