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606,025 grants found
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Behavioral Intervention Development Core
Project Abstract – BID Core The scientific premise underlying this proposed Roybal Center is as follows: most known modifiable intervention targets for, and outcomes of, EM have ro...
Closed-loop digital interventions through a remote clinical trials platform.
Project Summary / Abstract: Overall The overall theme of this Roybal Center is to leverage technology to facilitate memory and cognitive function so that cognitive decline may be p...
Admin Core
Project Summary / Abstract: Administrative Core The Roybal Center Administrative Core will provide scientific leadership, organizational management and governance, financial oversi...
BID Core
Project Summary / Abstract: Behavioral Intervention Core The overall goal for this Roybal Center Behavioral Intervention Development (BID) Core is to leverage technology to facilit...
Establishing Mechanisms of Benefit to Reinforce the Alzheimer's Care Experience AD/ADRD Roybal Center: EMBRACE
Program Summary/Abstract-Overall With the advent of the National Alzheimer’s Project Act of 2011, funding and support to advance the science of dementia care has increased substant...
Establishing Mechanisms of Benefit to Reinforce the Alzheimer's Care Experience AD/ADRD Roybal Center: EMBRACE
Program Summary/Abstract-Administrative Core Robust research infrastructure capable of advancing the science of dementia care interventions in the home and community is necessary....
Establishing Mechanisms of Benefit to Reinforce the Alzheimer's Care Experience AD/ADRD Roybal Center: EMBRACE
Project Summary/Abstract-Behavioral Intervention Development Core The proposed Establishing Mechanisms of Benefit to Reinforce the Alzheimer’s Care Experience AD/ADRD Roybal Center...
Penn State Roybal Center for Promoting Adherence to Behavior Change and Enhancing Cognitive Function
PROJECT SUMMARY - OVERALL The goal of the Penn State Roybal Center is to develop and test novel interventions to improve adherence to behavior change and enhance cognitive function...
Penn State Roybal Center for Promoting Adherence to Behavior Change and Enhancing Cognitive Function
PROJECT SUMMARY – ADMINISTRATIVE CORE The goal of the Administrative Core for the Penn State Roybal Center is to accelerate the translation of basic research on mechanisms of adher...
Penn State Roybal Center for Promoting Adherence to Behavior Change and Enhancing Cognitive Function
PROJECT SUMMARY – BEHAVIORAL INTERVENTION DEVELOPMENT CORE The goal of the Behavioral Intervention Core for the Penn State Roybal Center is to develop principle-driven scalable and...
Connectome 2.0: A BRAIN Technology Integration and Dissemination Resource for Ultra-High Gradient Magnetic Resonance Imaging of Human Brain Circuits Across Scales
SUMMARY The goal of this proposal is to disseminate Connectome 2.0, the next-generation 3 Tesla human MRI scanner at the Massachusetts General Hospital designed for imaging human b...
Epigenetic Age and Patient Outcomes after Severe Traumatic Brain Injury
ABSTRACT Aging is a risk factor for many chronic conditions including Alzheimer’s disease (AD) and Alzheimer’s disease related dementias (ADRD) and impacts patient outcomes after t...
The influence of asthma on walking in older adults: brain predictors, medication adherence and asthma control
The increased prevalence of asthma among older adults and its associations with multiple adverse health outcomes including poor cognition are of significant public health concern....
Planning a childhood sJOgren disease Use of Randomized N-of-1 Evaluation of therapY JOURNEY
Project Summary/Abstract: Childhood Sjögren's disease (cSD) is a rare autoimmune disease that primarily affects the glands, leading to salivary and lacrimal gland inflammation...
Innate sensing of M. tuberculosis by alveolar macrophages
PROJECT SUMMARY Mycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis (TB) is one of the leading causes of death globally by a single infectious agent. There contin...
Neurocognitive Effects of Late-Childhood Iron Deficiency Anemia
PROJECT SUMMARY Iron deficiency anemia (IDA) experienced in early childhood causes long-lasting negative consequences on brain development, connectivity and cognition. Given the hi...
A longitudinal, randomized-controlled experiment of healthy food policies in online retail settings
PROJECT SUMMARY Unhealthy diets significantly contribute to major preventable chronic diseases including type 2 diabetes, obesity, heart disease and stroke, which disproportionally...
Striatal Dopamine Signals Underlying Valence-Dependent Learning
Project Summary Real-life learning occurs through feedback in the form of reward or punishment. Dopamine is a key molecule in the brain known to play a central role in learning fro...
Gene Editing for Hemophilia A Treatment Using Lipid Nanoparticles
PROJECT SUMMARY The goal of this project is to combine the technology of lipid nanoparticles (LNPs) and CRISPR/Cas9 gene editing tools to correct the mutant factor VIII (FVIII) gen...
Elucidating Regulation of Cell Fate Specification in Human Cortical Development to Understand Etiology of Neurodevelopment Disorders
PROJECT SUMMARY The human brain has an expanded cortex compared to its closest relatives, and this outer layer of the brain provides humans with complex functions including integra...