Browse All Grants
606,025 grants found
Showing 34,321 – 34,340 of 606,025 grants
BRAIN CONNECTS: Scalable Approaches for Bidirectional Brain-wide Trans-Neuronal Connectivity Mapping of Defined Cell Types
PROJECT SUMMARY A major goal in modern neuroscience is to comprehensively map circuits of synaptically connected cell types throughout the mammalian brain. The key technological ga...
Biophysical properties of lymph nodes in aging
Summary Aging reduces our bodies’ ability to respond to pathogens and vaccines. This is thought to at least in part be due to impaired functions of adaptive immune cells, which are...
Synthesis and Evaluation of a Bivalent Glycoconjugate Vaccine for Prevention of Infection with Acinetobacter baumannii
The proposed work will involve the synthesis and evaluation of glycoconjugates designed to trigger adaptive immune responses that provide protection against infection by the bacter...
A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy for Back Pain
PROJECT SUMMARY Low back pain affects nearly half of all Americans per year and accounts for nearly three million annual emergency department (ED) visits. In nearly two thirds of t...
Defining Novel Roles of Platelets and Macrophages in the Healing of Abdominal Aortic Aneurysm
ABSTRACT (Project Summary) Rupture of abdominal aortic aneurysms (AAA) leads to sudden death in 15,000 to 30,000 men and women over the age of 65 each year in the US, and this numb...
Modulating spinal interoceptive pathways to evaluate their role and therapeutic potential in MDD symptomatic domains
Project summary Spinal interoceptive pathways (SIPs) convey bodily signals to an interoceptive system in the brain and their dysregulation is linked to major depressive disorder (M...
Restoration of reduced nitric oxide bioavailability in Preeclampsia
PROJECT SUMMARY: Our lab in collaboration with Akkadian Therapeutics, Inc. (AKTX), have demonstrated the beneficial effects of the novel catalytic radical scavenger and nitric oxid...
Racialized inequities in birth outcomes and maternal health following childbirth: the role of maternal early-life disadvantage, adolescent contexts, and pre-pregnancy stress
PROJECT SUMMARY/ABSTRACT: This proposed study assesses how social contextual stressors over the maternal pre-pregnancy life course contribute to the unacceptably wide racialized in...
RNA Modification Changes in Alcohol-Associated Liver Disease
Abstract. Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver diseases. The progressive nature of alcohol-associated liver disease (ALD) ha...
Mindfulness to Enhance Cognitive Health in Latinx Older Adults at Risk for Alzheimer's Disease
PROJECT ABSTRACT As the world ages, Alzheimer’s Disease (AD) and related dementias are quickly becoming some of the most pernicious and burdensome diseases around the globe. This b...
Implementation and pilot testing of a culturally centered CBT protocol for suicidal behaviors among youth in Mexico City
PROJECT SUMMARY/ABSTRACT The risks of ideating, suicide attempt (SA), and dying by suicide have never been greater for Mexican teens. In the past two decades, the rates of suicidal...
Persistent Effects of Dietary Protein Restriction on Protein Motivation and Underlying Physiology
Project Summary It is often assumed that animals rapidly adapt behaviorally and physiologically to nutritional challenges and that adaptations to such challenges carry implications...
Arizona State University Roybal Center for Older Adults Living Alone with Cognitive Decline: Technology-Enabled Behavioral and Lifestyle Change to Delay Alzheimer's Disease and Improve Quality of Life
Abstract (Overall) Living alone has emerged as a risk factor for Alzheimer’s disease (AD) and related dementias (ADRD) that will affect 14 million Americans, particularly African a...
ASU Roybal Administrative Core
Abstract (The Administrative Core) Living alone has become increasingly common over the past few decades among older adults, including those with cognitive decline (defined as subj...
ASU Roybal Behavioral Intervention Development (BID) Core
Abstract (The Behavioral Intervention Development [BID] Core) Behavior and lifestyle Interventions have shown promising effects on cognition, functional status, and quality of life...
MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer's Disease and Related Dementias (CONFIDE-ADRD)
PROJECT SUMMARY (OVERALL): The scientific theme of the “MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer’s Disease and Related Dementias” (C...
MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer's Disease and Related Dementias (CONFIDE-ADRD): Administrative Component
PROJECT SUMMARY (ADMINISTRATIVE CORE): The mission of the “MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer’s Disease and Related Dementias”...
MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer's Disease and Related Dementias (CONFIDE-ADRD): Behavioral Intervention Development Core
PROJECT SUMMARY (BEHAVIORAL INTERVENTION DEVELOPMENT CORE): The mission of the “MassaChusetts General Hospital ROybal CeNter For BehavIoral Dyadic ResEarch in Alzheimer’s Disease a...
Roybal Center for Elder Mistreatment Intervention Research
Project Abstract – Overall Component The Roybal Center for Elder Mistreatment Intervention Research will contribute significant, impactful scientific progress to the elder mistreat...
Administrative Core
Project Abstract – Admin Component The overall goal of the Administrative Core is to oversee the infrastructure of the Roybal Center for Elder Mistreatment Intervention Research. S...