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606,025 grants found
Showing 34,281 – 34,300 of 606,025 grants
A Randomized Controlled Trial Examining Extended-Injectable Buprenorphine in those who use High Potency Synthetic Opioids
Project Summary Opioid use disorder (OUD) presents a serious public health problem despite available and effective medications for OUD (MOUD). One factor complicating treatment del...
Do Hospices Specializing in Long-Term Care Settings Provide Better Care to Beneficiaries with Alzheimer's and Related Dementia?
PROJECT SUMMARY Hospice programs have been historically less experienced in caring for beneficiaries with Alzheimer’s and Related Dementia (ADRD), although ADRD represents one of t...
Stroma-penetrating nanomedicine to improve treatment for pancreatic cancer
PROJECT SUMMARY Annually, pancreatic cancer (PC) has a global incidence of more than 495,000 cases and a mortality rate of almost 460,000 cases. Most of these patients (~80%) recei...
Novel therapy to prevent alveolar bone loss in severe periodontitis
Novel therapy to prevent alveolar bone loss in severe periodontitis Abstract Periodontal disease affects almost half of US adults 30-years and older. More advanced disease, periodo...
Novel Gene Therapy, Techniques, and Devices to Prevent Ventricular Tachycardia
ABSTRACT In the United States, several hundred thousand people experience cardiac arrest each year, with the vast majority dying from this condition. Approximately two-thirds of ca...
SHP2's Regulation of the Bone Marrow Stroma and Hematopoietic Crosstalk
(PLEASE KEEP IN WORD, DO NOT PDF) (Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.)It has been...
Environmental risk factors linked to TDP-43 proteinopathies
ABSTRACT Most neurodegenerative diseases are sporadic with unknown etiology that likely stems from the interaction between genetics and the environment, the latter of which continu...
Molecular effects of cannabinoids on the Blood Brain Barrier in HIV-infected brain
Molecular effects of cannabinoids on the Blood Brain Barrier in HIV-infected brain Infection with the human immunodeficiency virus (HIV) causes significant disease morbidity in the...
Engineering promiscuous enzymes for synthesis of biological building blocks
The use of enzymes in synthesis has had an enormous impact on the development of bioactive compounds, as they can perform transformations with unparalleled selectivity at a low cos...
Signaling, Sensing, and Enzymatic Roles of Disordered Selenoproteins
PROJECT SUMMARY Selenoproteins are prominently engaged in the integrated cellular response to stress. Here we focus on the ER- bound membrane proteins selenoprotein K (selenok) and...
The potential benefits of autophagy activator TFEB in opioid use disorder in mice
PROJECT SUMMARY In the United States, the prevalence of opioid use and opioid use disorder (OUD) more than doubled in recent years. There has been an increase in opioid-related ove...
University of Michigan Skin Biology and Diseases Resource-based Center
PROJECT SUMMARY - OVERALL The overall goal of the University of Michigan Skin Biology and Diseases Resource-based Center (UM- SBDRC) is to leverage our strengths in genomic editing...
Administrative Core
PROJECT SUMMARY A NIAMS resource-based center that provides critical infrastructure and unique services, is inclusive, collaborative, multidisciplinary, and leverages existing univ...
Functional Analytics Core
PROJECT SUMMARY – Functional Analytics Core (FAC) The University of Michigan Skin Biology and Diseases Resource-based Center (UM-SBDRC) Functional Analytics Core (FAC) is a Resourc...
Animal Modeling Core
PROJECT SUMMARY The Animal Modeling Core (AMC) of the University of Michigan Skin Biology and Diseases Resource-based Center (UM-SBDRC) serves as a critical shared resource that fa...
ENLIGHTEN (ENgaging Leaders In Global and local HealTh Equity in Neurology)
PROJECT ABSTRACT This is a proposal to support the ENgaging Leaders In Global and local HealTh Equity in Neurology (ENLIGHTEN) training program. The goal of ENLIGHTEN is to prepare...
Glacios 2 Cryo-TEM for Structure Analysis
PROJECT SUMMARY Advances in single particle cryo-EM have transformed structural biology of ever-expanding biological systems. We request funds to purchase a Glacios 2 cryo-TEM (The...
Functional Ultrasound (fUS) Neuroimaging System
PROJECT SUMMARY We propose to purchase a new Iconeus One functional ultrasound (fUS) neuroimaging system from the company, Iconeus, to enhance the biomedical ultrasound and neuroim...
The role of paracrine growth factor signaling in thymus function and age-associated dysfunction
The thymus is the primary site of T lymphocyte development, where mutually inductive signaling between lymphoid progenitors and thymic epithelial cells (TECs) directs the progenito...
MicroSPECT/CT to aid the development of theranostics
Project Summary We propose to purchase a new Mediso nanoScan preclinical SPECT-CT scanner at Case Western Reserve University (CWRU). This new SPECT-CT system will restore the precl...