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606,025 grants found
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Validating SER-014, a TRPV1 antagonist, to treat endometriosis
Validating SER-014, a TRPV1 antagonist, to treat endometriosis Summary Endometriosis is a chronic inflammatory condition that affects ~10% of women and often results in debilitatin...
Resolving transcription factor target search mechanisms
Project Summary Proper gene expression regulation is pivotal for cellular function, and its dysregulation contributes to disease. Transcription factors (TFs) initiate gene expressi...
Bio-orthogonal Mid-Infrared Photothermal Imaging of Cancer Metabolism
Project Summary Understanding how cancer cells reprogram their metabolism and interact with other biological processes to gain aggressiveness and/or resistance to a treatment is of...
Activity Probes to Guide Precision Microbiome Therapy
The microbiome has emerged as a functional microbial organ system that plays a key role in human health and disease including obesity, cancer, and inflammation. Dietary and host fa...
Saf-T-Drape: Sterile Drapery Shielding for Radiological Scanners
Abstract: Saf-T-Drape: Sterile Drapery Shielding for Radiological Scanners Current drapery solutions for MRI, CT, and PET scanners are inconvenient to install, prone to failure dur...
The Role of the Macrophage in Bacterial Vaginosis Mediated HIV Risk
Project Summary/Abstract BV is driver of the HIV epidemic, increasing HIV risk up to 60%. Bacterial Vaginosis (BV) is the most common vaginal condition among women of reproductive...
Quantification of molecular interactions across the matrix spectrum enables cancer research.
Project Summary We propose to further develop, refine, and validate our emerging free-solution assay (FSA) technology and our relatively new compensated Interferometric reader (CIR...
Optimizing Dual Therapy for Chronic Prostatitis/Chronic Pelvic Pain Syndrome
SUMMARY Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is the most common urological condition affecting men under the age of 50. With an estimated prevalence of 6-12%...
TARGETING SIGNALING BETWEEN GLIOBLASTOMA AND THE SUBVENTRICULAR ZONE NICHE
TARGETING SIGNALING BETWEEN GLIOBLASTOMA AND THE SUBVENTRICULAR ZONE NICHE Glioblastoma (GBM) is the most malignant and proliferative primary brain tumor in adults. It remains a th...
Multiplexed, Continuous Reporting of Gene Expression via CRISPR-mediated Transcriptional Activation
PROJECT SUMMARY: Although the detection of gene expression by quantitative PCR, bulk or single cell RNA sequencing represents a cornerstone of biological inquiry, these approaches...
Virtual chromatographic cytometry for in-line biomanufacturing process analysis
Project Summary/Abstract Gene therapy is an emerging therapeutic technology that uses genes in targeted cells to prevent and/or treat acquired disorders and inherited genetic disea...
A novel platform for targeted radiopharmaceuticals for imaging and therapy of ovarian cancer
Project Summary The goal of this Phase I STTR is to continue development of Oncurie’s novel ovarian cancer targeting compound, which binds to the folate receptor and delivers radio...
Gene Therapy for Idiopathic Parkinson's Disease
There is no cure or disease-modifying therapy for patients diagnosed with idiopathic Parkinson’s Disease (idPD) that carry no genetic mutations and have no family history of this d...
A Pilot Clinical Study for a Novel Bioresorbable Bone Adhesive to Evidence Improved Cranial Flap Fixation Based on Radiographic Imaging and Patient Reported Outcomes
Project Abstract In 2018 approximately 210,000 people in the U.S. underwent a craniotomy requiring cranial flap closure. The instruments used to cut into the skull leave a continuo...
Development of ablative therapy for the destruction of cervical neoplasia
PROJECT SUMMARY Cervical intraepithelial neoplasia (CIN) is caused by the sexually transmitted Human Papilloma Virus (HPV), which infects 14 million women in the US every year and...
Active Arm-Support Industrial Exoskeleton to Reduce Work-Related Musculoskeletal Disorders (WRMSDs)
Project Summary/Abstract The proposed project focuses on creating an active assistance arm-support exoskeleton to reduce work- related musculoskeletal disorders (WRMSDs) in careers...
Discovering novel natural products from fungal species
Project Summary. Antibiotic resistance is becoming a major public health problem worldwide, with antibiotic resistant pathogens infecting hundreds of millions and killing over a mi...
Reimagining Pharmaceutical Drug Development in Oncology with a Biomimetic Platform
SUMMARY More efficient processes for drug development make possible new effective therapies for rare cancers that have unmet clinical needs. In the pharmaceutical industry, narrowi...
An intravaginal, wearable device for treating women with pelvic floor myofascial pain
Abstract High tone pelvic floor dysfunction (HTPFD) is a major contributor to chronic pelvic pain, affecting up to 15% of women in the United States. Intravaginal Electrical Stimul...
Development of a Novel Calcium Channel Therapeutic for Dystrophinopathies
Vivreon Biosciences, LLC 4940 Carroll Canyon Rd. Suite 110 San Diego, CA 92121 [email protected] Vivreon Biosciences – NIAMS PA-23-230 Project Summary Vivreon is an inn...