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606,025 grants found
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Novel Optical Scanning Probe Microscope for Biomedical Chemical Imaging with Ultra-High Spatial Resolution and Chemical Sensitivity
Abstract: Understanding molecular mechanisms of diseases and manipulating them to achieve cure constitutes one of the "holy Grail" of biomedical science. Infectious (and...
Therapeutic Targeting of Mitochondria in Uromodulin-Associated Chronic Kidney Disease
Uromodulin (UMOD)-associated chronic kidney disease (CKD), or autosomal dominant tubulointerstitial kidney disease caused by UMOD mutations (ADTKD-UMOD), is characterized by progre...
Feasibility of a Video Telehealth Functional Assessment for Veterans with Dementia
Background. Veteran access to an assessment of day-to-day function is vital to enable aging-in-place. Older Veterans are more likely to have dementia, which results in progressive...
Epigenetic mechanisms in a novel model of FSGS
Focal segmental glomerulosclerosis (FSGS) is a pathologic descriptive diagnosis of glomerular scarring (fibrosis). Many types of kidney injury including inherited mutations, drug t...
Artificial thymic organoid platform to study T cell development and HIV/SIV infection using SIV/macaque model of HIV/AIDS
PROJECT SUMMARY Functional CD4+ T lymphocytes are progressively lost during HIV/Simian Immunodeficiency Virus (SIV) infection and must be continuously replaced. Hematopoietic stem...
Improving hypertension care for persons with HIV in Indiana: a participatory agent-based model
ABSTRACT Cardiovascular disease (CVD) has become a leading cause of morbidity and mortality in persons with HIV (PWH). Although clinical guidelines recommend detecting and addressi...
Utilizing Implementation Research Methodologies to Adapt an Intervention to Reduce Alcohol Use and Improve HIV Care Outcomes among Men Living with HIV who have Serodiscordant Pregnant Partners
PROJECT SUMMARY Hazardous alcohol use is prevalent among men living with HIV (MLWH) in Uganda and associated with non- adherence to antiretroviral therapy (ART) and detectable vira...
Designing adaptive implementation strategies for mental health care in persons living with HIV in South Africa (DASH-SA)
ABSTRACT Depression and other mental health conditions are disproportionately common in people with HIV and continue to compromise quality of life and impede achievement of optimal...
INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)
Project Summary/Abstract Globally, 75% of people living with HIV (PLWH) are receiving antiretroviral therapy (ART), but only 67% of them are virally suppressed, with ART medication...
Direct-to-family pharmacokinetics intervention for hydroxychloroquine non-adherence in adolescents with systemic lupus erythematosus
PROJECT SUMMARY/ABSTRACT Half of adolescents with pediatric systemic lupus erythematosus (pSLE) do not take medications regularly as prescribed. Non-adherence increases the risk of...
Intra-graft C1 esterase inhibitor therapy for deceased kidney transplantation
Kidney transplantation is the optimal therapy for end stage kidney disease (ESKD) but current transplant outcomes are suboptimal, particularly for recipients of organs obtained fro...
CTSA K12 Program at Baylor College of Medicine and University of Houston
The K12 Companion Application for our CSTA, entitled “Consortium for Translational and Precision Health (CTPH)”, seeks to promote the career development of early-career faculty mem...
NUCATS CTSA UM1 at Northwestern University
PROJECT SUMMARY/ABSTRACT Over prior funding cycles, the Northwestern University Clinical and Translational Sciences (NUCATS) Institute has developed and delivered a robust institut...
Consortium for Translational and Precision Health
The Consortium for Translational and Precision Health (CTPH) will serve as a unique bi-institutional hub for infrastructure, services, community engagement, and workforce developme...
5/6 NJ ACTS: A Platform for Translational Science in New Jersey: CTSA R25 at Rutgers, Biomedical Health Sciences
PROJECT SUMMARY Creating a pathway for trainees to enter the clinical and translational science (CTS) workforce, including students from backgrounds often underrepresented in STEM...
Identifying Needs and Building Research Capacity at an Historically-Black University
Identifying Needs and Building Research Capacity at an Historically-Black University Summary Delaware State University (DSU) is an Historically-Black University with an emerging ex...
Fluorescence lifetime-based tumor contrast enhancement using exogenous probes
Imaging techniques that can enhance tumor contrast against non-specific background can significantly impact diagnostic and surgical applications in oncology. Fluorescence optical i...
Center for American Indian and Rural Health Equity (CAIRHE)
The mission of the Center for American Indian and Rural Health Equity (CAIRHE) is to reduce significant health disparities in Indigenous and rural communities across Montana while...
Administrative Core, Center for American Indian and Rural Health Equity (CAIRHE)
The overarching aim of the Center for American Indian and Rural Health Equity, or CAIRHE, is to position itself as the state and regional leader in multidisciplinary health equity...
Montana IDeA Community Engagement Core, Center for American Indian and Rural Health Equity (CAIRHE)
The Center for American Indian and Rural Health Equity (CAIRHE) achieves its research mission through multidisciplinary community-based participatory research (CBPR) that is consid...