Browse All Grants
606,025 grants found
Showing 29,681 – 29,700 of 606,025 grants
Protecting Healthcare Workers Using a Patient-Worn Negative Pressure System to Prevent the Spread of Highly Transmissible Infectious Diseases
PROJECT SUMMARY The goal of this project is to develop a solution that allows for rapid, safe, and scalable initial treatment and transport of patients with highly transmissible in...
m6A Modification of HIV RNA Affects its Post-transcriptional Processing
PROJECT SUMMARY/ABSTRACT HIV has a complex expression pattern of RNA with three different classes of transcripts: unspliced, singly spliced, and multiply spliced. The unspliced tra...
iLIGN - Artificial Intelligence Driven Strabismus Pre-Screening System
SUMMARY The overall goal of this project is to develop a rapid, non-invasive, accurate, and low-cost smartphone application (app), called iLIGN, to perform automated pre-screening...
Pre-operative planning for surgical treatment of patellar instability
Project Summary/Abstract Acute patellar dislocation and chronic patellar maltracking and subluxation disproportionately affects active young people, impairing functional ability, c...
Developing Technology to Remotely Measure Molecular Composition
There is a critical need for accurate and safe early stage detection of, e.g., infectious diseases, hazardous materials, and otherhealth related issues. Remote detection directly f...
Cutaneous Gel Delivering an Intriguing MOA Therapeutic to Treat DFU
PROJECT SUMMARY Diabetes mellitus is a chronic metabolic disorder that has reached epidemic proportions globally. One of the most important complications of diabetes is the major r...
Development of VBI-1 as a novel treatment protocol for outpatient cardiac arrest
PROJECT SUMMARY Cardiac arrest (CA) is a life-threatening condition that can lead to loss of pulse, cessation of breathing, and unconsciousness. In the US alone, over 805,000 peopl...
Harnessing SHIVs and Sequential Immunization to Elicit V3 Glycan-Targeted bNAbs against HIV-1
PROJECT SUMMARY/ABSTRACT Over 1.8 million people are newly infected with HIV each year, and despite decades of research since the onset of the AIDS pandemic, we still do not have a...
A Multimethod Approach of Social Disconnection in Schizophrenia: Leveraging Digital Phenotyping, Social Network Analyses, and Neuroimaging
Humans are inherently social and form meaningful relationships with family members and friends. However, developing these relationships is difficult for Veterans with schizophrenia...
Development of gene therapy product for treating MPS IIIB
Project Summary The goal of this fast-track SBIR project is to further develop AAV gene therapy product for treating Mucopolysaccharidosis (MPS) IIIB towards clinical application a...
D
Project Summary (Core D: Pilot Project Core) The purpose of the Pilot Project Core is to fund pilot projects that are likely to produce new collaborations, publications, and grants...
Dissemination of a Facilitation Strategy to Deimplement Unnecessary Post-Operative Antibiotics at Children's Hospitals
PROJECT SUMMARY Background: Antibiotic overuse results in antimicrobial resistant (AMR) bacteria and unnecessary adverse events including Clostridioides difficile infections (CDI)...
Late-stage Pre-clinical Development and GMP Production of a First-in-Class Extended Release IOP-lowering Formulation
Glaucoma is a multifactorial, polygenetic disease that is the leading cause of irreversible blindness worldwide. Trends predict that by 2040, ~112 million people worldwide will hav...
Development of a novel kit for reduction of aerosolized particles during endonasal surgeries: the PharynVac Device
Project Summary Sinonasal surgery is extremely common (>600,000 outpatient procedures annually). There are three issues that can be mitigated with a single device: surgical staf...
Novel Isotopic Spectroscopy Imaging Tools for Advancing Targeted Alpha Cancer Therapies
Project Summary / AbstractTargeted alpha therapy is an emerging technique for treating cancer showing great promise to deliver a precise and potentcell-killing treatment to multipl...
Cellular Mechanisms of Lysosomal Damage Response
PROJECT SUMMARY Lysosomes are essential membrane-bound organelles that play a vital role in cellular degradation and signaling. Damage to lysosomes can be triggered by numerous phy...
The NH Explanatory Trials Network: Supporting Transformation by Enhancing Partnerships (The NEXT STEPS).
The proposed project, NEXT STEPs (Nursing Home EXplanatory Clinical Trials: Supporting Transformation by Enhancing Partnerships) Network, creates a national infrastructure that wil...
Extending duration of an injectable long-acting local anesthetic formulation using novel salts
Project Summary Over 14,000 people die of prescription opioid misuse per year. Opioid-based medications are a mainstay of postoperative pain management with approximately 80% of su...
A CB1 Antagonist for Treatment of Kidney Disease
OTHER PROJECT INFORMATION – Unit 7 - SUMMARY/ABSTRACT Chronic kidney disease (CKD) is a major public health issue affecting ~700 million worldwide, including 15% in the US. The mos...
Achieving health equity through food as medicine and medically tailored meals: local economic opportunity
Diet-related disparities are attributed to factors experienced by historically disadvantaged communities, such as inadequate access to healthy food and socio-economic stressors. Po...