Browse All Grants
606,025 grants found
Showing 29,621 – 29,640 of 606,025 grants
Impact of obesity on antiviral NK cell function and immune crosstalk with respiratory epithelial cells during influenza virus infection
RESEARCH SUMMARY Respiratory infections, including those caused by influenza A virus (IAV), significantly contribute to worldwide mortality and morbidity. Vulnerable populations, s...
The Structural and Biochemical Effects of XFG-Associated Variants in LOXL1
PROJECT SUMMARY/ABSTRACT The goal of this project is to structurally and biochemically characterize wild-type LOXL1 and LOXL1 containing variants associated with pseudoexfoliation...
CyTOF XT with Hyperion XTi platform
PROJECT SUMMARY A group of eleven NIH-funded investigators requests funding for the purchase of a Standard Biotools CyTOF XT mass cytometer with the Hyperion XTi imaging platform,...
Structural Mechanism of Activation and Modulation of Tie2-mediated Angiogenesis
PROJECT SUMMARY The cardiovascular system is an essential organ key for development. This highly efficient network of vasculature structures constantly undergoes expansion and trim...
Unraveling alphavirus neuroinvasion: Molecular insights from a stem cell based blood-brain barrier model
PROJECT SUMMARY Alphaviruses are mosquito-borne viruses that can cause arthritis and fatal encephalitis in humans with no approved therapeutics. Encephalitic alphaviruses, like Sin...
Early Sleep Disruption and Neurodevelopmental Trajectories in Infancy
Abstract Despite the critical role of sleep in brain development during infancy, little is known about the impact of early sleep disturbance in typical and atypical development. Sl...
Neural Substrates of Word Retention and Generalization in Toddlers
PROJECT SUMMARY Infants and young children amass a vocabulary at a remarkable pace during the first 3-years. The size of vocabulary, and the rate of its growth predict future outco...
Nef in impaired efferocytosis: a novel mechanism for vascular disease in HIV
Project Summary Anti-retroviral therapy (ART) has protected many HIV patients against the development of AIDS. HIV infection has become a treatable disease. Increased risk for athe...
Combining rTMS & aerobic exercise to treat depression and improve post-stroke walking (RESTORATION)
Project Summary Depression is the most common neuropsychiatric manifestation following stroke and current treatments are largely ineffective. Depression has both direct and indirec...
Pathoadaptive Modulation of Porphyromonas gingivalis Lipopolysaccharide Structure and Function
Project Summary Periodontitis is a polymicrobial-driven and prevalent inflammatory disease of the tissues supporting the teeth in adults. Studies revealed highly active biosynthesi...
Image-guided robotic assistance to improve precision and reduce x-ray dose in orthopedic surgery for pediatric SCFE
Project Summary Placement of orthopaedic implants, such as guidewires and screws, is a common surgical task, and accurate placement is critical to the success of a range of orthopa...
Cerebral spinal fluid serotonin and adenosine levels detect secondary injuries in traumatic spinal cord injury patients
Project Summary and Abstract. Candidate: My primary career objective is to lead a research program focused on preventing secondary insults in spinalcord injury (SCI) patients. This...
Harnessing human gut-derived Bacteroides to drive systemic anti-tumor immunity
Although immune checkpoint blockade has transformed therapeutic options for lung cancer, its efficacy differs widely even between patients with remarkably similar disease, and whil...
Interdisciplinary group care for the treatment of endometriosis-associated pain
PROJECT SUMMARY/ABSTRACT Endometriosis affects 10-15% of women, causing musculoskeletal pain, bowel and bladder problems, mood disorders, and infertility. Chronic pelvic pain is th...
LeveRaging Community Engagement to SusTAIN NCD InTegrated Care Models (RETAIN-IT)
PROJECT SUMMARY The increased life expectancy of people living with HIV/AIDS (PLWH) and the associated burden of non- communicable diseases (NCDs) in PLWH has prompted an urgent ne...
Designing and evaluating a Single-session Transdiagnostic intervention for Emotion Regulation with follow-up mHealth support for domestic violence survivors in India.
Project Summary/Abstract Domestic violence (DV) is a widespread global public health concern, with higher prevalence rates in low -and- middle-income countries (LMIC), such as Indi...
Neurovascular Mechanisms of Kidney Disease Progression in Older Adults
PROJECT SUMMARY The overall purpose of this K01 proposal is to provide the PI with the essential mentorship, career development, and research experience necessary to become an inde...
Increasing Access To Depression Care For Black Women Survivors Of Intimate Partner Violence
Black women intimate partner violence (IPV) survivors experience a higher burden of depression.1 IPV is any physical, sexual, psychological, or financial abuse, and/or controlling...
Improving the Assessment of Patient-reported Outcomes among Black/African-American Cancer Patients
Project Summary Willi L. Tarver is an Assistant Professor in the Division of Cancer Prevention and Control, College of Medicine at The Ohio State University. Dr. Tarver is respondi...
Assessing Metals and Flame Retardant Exposures on Solid Waste Workers
Abstract The US solid waste industry employed approximately 433,000 workers in 2022, in various roles including waste collection, sorting, recycling, processing, and disposal. Thes...