Browse All Grants
606,025 grants found
Showing 29,601 – 29,620 of 606,025 grants
Quantifying the contribution of supracellular actomyosin networks during mouse neural tube closure
PROJECT SUMMARY/ABSTRACT Tissues are sculpted into 3D shapes through coordinated force generation during embryogenesis. Force generation is mediated by the cytoskeletal protein, F-...
Metals, the Microbiome, and Kidney Health Among Adolescents in Central America
ABSTRACT Chronic kidney disease of unknown etiology (CKDu) is a deadly disease among young people in Central America, especially agricultural workers. Risk factors and presentation...
Mechanisms of endocrine therapy and radiation synergism to decrease brain metastases
PROJECT SUMMARY The increasing number of young women diagnosed with metastatic breast cancer has awakened the urgency to define why they are more likely to suffer from aggressive b...
Mitochondrial metabolism controls alveolar epithelial cell fate
PROJECT SUMMARY/ABSTRACT Patients with severe pandemic SARS-CoV-2 pneumonia suffered damage of alveolar epithelial cells due to direct viral injury, subsequent immune response, and...
Defining the Mechanistic Impact of PRC1 Overexpression on Mammalian Spindle Mechanics
Project Summary/Abstract Errors in chromosome segregation lead to aneuploidy, a hallmark of cancer. While we know nearly all molecules involved in mammalian cell division, we do no...
ACQUISITION OF A QTRAP 7500 HYBRID QQQ/LIT MASS SPECTROMETER FOR PEDIATRIC TRANSLATIONAL RESEARCH
ABSTRACT The ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) system consisting of a SCIEX QTRAP® 7500 MS System and Shimadzu Nexera Series 40 UHP...
Integrating Multi-Omics into Ongoing NIH Research through Artificial Intelligence
SUMMARY This proposal requests funds to acquire a high-performance computing (HPC) cluster with extensive data storage and Graphics Co-Processor (GCP) capabilities for the Medical...
Instrument Grant for Truelive 3D
Abstract The ease of access to quantitative imaging technologies such as laser-scanning confocal microscopy has ushered in a revolution in our understanding of the inner workings o...
Characterizing Oncogenic Nras in IDH1 Mutant AML Leukemogenesis and Therapeutic Responsiveness
PROJECT SUMMARY/ABSTRACT Acute Myeloid Leukemia (AML) is a lethal hematologic malignancy characterized by impaired myeloid differentiation and blast proliferation, inhibiting norma...
Biomechanics and mechanobiology of human uterine fibroids
PROJECT SUMMARY/ ABSTRACT Uterine fibroids are the most prevalent noncancerous growths that form within the female body, present in 70 - 80% of women by age 50, and may result in s...
Acquisition of a FACSymphony S6 Sorter for the University of Toledo Flow Cytometry Core
This is a shared instrumentation grant application to acquire a BD FACSymphony S6 flow cytometer to replace a 16-year-old BD FACS Aria™ IIu for the University of Toledo (UToledo) F...
ZetaView x30 QUATT Multi-Fluorescence Nanoparticle Tracking Analyzer
We are requesting funds for a ZetaView® x30 QUATT Multi-Fluorescence Nanoparticle Tracking Analyzer with colocalization of four lasers. This instrument is essential to biomedical r...
COVID-19 and the Health and Wellbeing of Vulnerable Service Sector Workers across the Life Course
ABSTRACT The COVID-19 pandemic precipitated intermingled health and economic shocks, which were felt deeply in the service-sector. The service-sector workforce is large, with nearl...
Coordinated growth in microbial communities and implications for antibiotic sensitivities
Project Summary The discovery of antibiotics greatly decreased the public health burden associated with bacterial infections; however, antibiotics also disrupt the beneficial micro...
The adolescent development of top-down feedback for visual processing
Project Summary Adolescence is an important period for neural and cognitive development. Many perceptual and cognitive abilities rely on inputs from higher cortical regions, which...
Investigating XRCC1 coordination with DNA polymerase beta in chromatin during BER
Project Summary/Abstract Reactive oxygen species (ROS) generated by exposure to environmental toxins are a constant source of DNA damage. If not properly repaired, this DNA damage...
Intercepting the Evolution of Pro-Tumoral Myeloid Cells During the Initiation of Oral Cancer
PROJECT SUMMARY/ABSTRACT Earlier detection and treatment of human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) has the greatest potential to improve...
Investigating the role of FOXA1/2 and HNF4⍺ in Pancreatic ductal adenocarcinoma
PROJECT ABSTRACT Cell identity, crucially controlled by transcription factors (TFs), is perturbed in cancer, contributing to highly aggressive and metastatic tumors, such as pancre...
Elucidating the complex allosteric regulation of PFK-1, a broadly evolutionarily conserved glycolytic enzyme
PROJECT SUMMARY/ABSTRACT Allosteric enzymes govern many metabolic and regulatory processes. Their regulation is modulated by the binding of an effector molecule to a site distal to...
Diverse Patterns of Activity-Dependent Alternative Splicing
Project Summary/Abstract Neural circuits can change their properties under changes in activity. Hebbian plasticity acts as a positive regulator to increase or decrease synaptic str...