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606,025 grants found
Showing 29,581 – 29,600 of 606,025 grants
HPV Attenuation of the cGAS/STING Pathway
Project Summary Globally, human papilloma virus (HPV) causes 5% of cancers and 30% of head and neck squamous cell carcinomas (HNSCC). While HPV is the most common sexually transmit...
Prehabilitation Exercise Training in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation
PROJECT SUMMARY Multiple myeloma is the second most prevalent hematologic malignancy in the US with an estimated 7.1 cases per 100,000. Patients diagnosed with multiple myeloma hav...
Characterizing the role of confirmation bias in financial exploitation of older adults
PROJECT SUMMARY/ABSTRACT Confirmation bias refers to the tendency to interpret new information in a way that conforms to one's pre-existing beliefs. It is associated with defi...
Defining factors affecting natural killer cells' antibody-dependent responses in COVID-19
PROJECT SUMMARY SARS-CoV-2, the causative agent of COVID-19, has become an extended public health challenge due to the emergence of variants that results in reduced protection by v...
Training West African Public Health and Clinical Research Professionals to Conduct Pan-Pathogen Surveillance Using Sustainable and Effective Genetic, Molecular, and Serological Approaches (TWA-PPPSA)
ABSTRACT The Global Alliance for Preventing Pandemics has a long and productive history collaborating with scientists, clinicians, and academics from Mali, Liberia, and many other...
Non-Classical Ion Channel Function in Human Cortical Histogenesis
Project Summary: Proper development of the human cortex is essential for brain function and depends on the synchronization of complex molecular and cellular processes. Malformation...
Characterizing age-related differences in T cell responses to stroke
PROJECT SUMMARY Aging is the greatest risk factor for vascular dementia, the second most common cause of dementia after Alzheimer disease (AD). Vascular dementia comprises a large...
Mechanistic Analysis of Aortic Growth and Remodeling due to Hyperglycemia and Recovery
PROJECT SUMMARY Diabetes is a heterogeneous disease characterized by chronic poor glycemic control, resulting in pathological changes in tissues throughout the body. Chronic hyperg...
Social determinants, trauma, and mental distress among forcibly displaced populations in low- and middle-income countries
PROJECT SUMMARY The goal of the proposed fellowship is to prepare the applicant, Lauren Yan, for a career in global mental health research to inform programmatic and policy interve...
Investigation of state-specific drug binding to cardiac ion channels to reveals mechanisms of arrhythmogenesis
Project Summary/Abstract Unintended drug block of cardiac ion channels remains a major problem in drug development. The voltage-gated potassium channel KV11.1 also known as the hER...
Deciphering the role of cytoskeletal-nuclear interactions in peripheral chromatin organization
Project Abstract The mammalian genome is organized into various regions at different scales as one mechanism to regulate gene expression and mediate cellular identity. One type of...
The role of mesothelial-derived cancer-associated fibroblasts in the pathogenesis of pancreatic ductal adenocarcinoma
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDA) is a deadly disease with a five-year survival rate of 12%. Oncogenic KRAS (Kras*) is a near-universal driver of PDA, and its...
Structural and antigenic characterization of human cytomegalovirus gB
PROJECT SUMMARY/ABSTRACT Human cytomegalovirus (HCMV) is a double-stranded-DNA, enveloped virus that infects most of the global population by establishing lifelong latent infection...
Investigating the role of BCAA metabolism in regulating adiposity during systemic hypoxia.
Project Summary/Abstract Obesity and increased adiposity contribute to cardiovascular disease and mortality, but high-altitude populations have lower rates of chronic metabolic dis...
Cerebral oxygen extraction efficiency in patients with sickle cell anemia
PROJECT SUMMARY This work proposes to refine novel non-invasive magnetic resonance imaging (MRI) methods to quantify cerebral oxygen extraction and to apply these methods in person...
A quantitative framework for measuring the coordination of central and peripheral body clocks in humans in the real world
PROJECT SUMMARY Night or rotating schedules under shiftwork are unavoidable, especially in healthcare work. Shiftwork can disturb circadian rhythms due to unusual light exposure an...
Quantification of Iron Oxide Nanoparticles in Cryopreserved Kidneys with Longitudinally Detected Electron Paramagnetic Resonance
Abstract Unfortunately, ~20% of kidneys donated for transplant are discarded due to short storage viability (~24-36 h). Cryopreservation decreases storage temperatures below -140oC...
Insular serotonin modulatesbehavioral responses to danger
Proposal Summary The long-term goal of this research training plan is to enhance our understanding of the neurobiology underlyingbehavioral responses to danger signals and provide...
Cell type-specific regulation of cortical development by the autism risk gene Foxp1
Project summary/abstract Autism spectrum disorders (ASD) are estimated to affect 1 in 36 children in the US, yet treatments for ASD remainlimited. Mutations in the transcription fa...
Using defective lipoylation as a window into cardiac fuel consumption and failure.
Project Summary Metabolism is essential for normal cellular function and dynamically changes to meet organism and tissue needs. Cardiac function and metabolism are closely intertwi...