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Feasibility Studies for the Future Mediterranean Glucose Lowering Dietfor Vision Extension in AMD (M-GLOVE-AMD)
PROJECT SUMMARY Age related macular degeneration (AMD) is a leading cause of vision loss in individuals over 55-years of age and is increasing as the world population becomes older...
Study the mechanisms of interaction between hiPSC-derived endothelial (ECs) and skeletal myogenic progenitor cells (MPCs) in vitro and in vivo
Project Summary/ Abstract Human induced pluripotent stem cells (hiPSCs) are among the top candidates for cell therapy due to their pluripotency and isogenic source. In case of skel...
Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic Cells
PROJECT SUMMARY (See instructions): Human cytomegalovirus (HCMV) establishes a latent infection in hematopoietic progenitor cells (HPCs) and cells of the myeloid lineage and its re...
Racial/Ethnic Disparities in Early Family Member Deaths and Young Adult Trajectories
Abstract Persistent racial/ethnic disparities in mortality in the U.S. create racial/ethnic disparities in young people’s exposure to death in their families. Such differential exp...
Redefining indications of EGFR inhibitors in cancers that harbor mutant RAS
Background: Anti-EGFR agents have been shown to benefit colorectal cancer patients, except for patients whose tumor includes a KRAS mutation. Data from multiple clinical trials sug...
Bioorthogonal methods for unveiling chemical reactivity
Project Summary The long-term goal of our research program is to develop chemistry that can facilitate the synergetic interaction between biomolecules and small molecules to achiev...
Effect of Neprilysin Inhibition on Myocardial Interstitial Fibrosis
PROJECT SUMMARY / ABSTRACT Heart failure with preserved ejection fraction (HFpEF) affects 2.5 million Americans and is associated with high morbidity and mortality. Few effective t...
Early Education, School Readiness, and Early School Success Among Children In Poverty: Exploring the Role of Parasympathetic Function in the Preschool Classroom
Project Summary School readiness skills prior to entering elementary school are crucial for later academic success and, importantly, these skills may act as a protective factor for...
A daily diary examination of the influence of intersectional stigma on blood pressure
Hypertension is the most important modifiable risk factor for cardiovascular disease (CVD), the leading cause of death and disability in adults worldwide. Stigmatized populations,...
Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation
Freezing of gait (FOG) is a common and debilitating manifestation of advanced Parkinson’s disease (PD) for which there are limited treatment options. Deep brain stimulation (DBS) o...
Investigating the interface of NLRX1 and immune aging
Project Summary/Abstract: Alterations in the immune system occur with aging, likely contributing to infections and malignancies. In T cells, probably the most prominent change with...
Molecular Mechanisms of Sugar Sensing by Insect Gustatory Receptors
PROJECT SUMMARY Animals desire sugars for their energy potential and for the pleasurable sensation of tasting sweetness. Despite the importance of sugar receptors in influencing nu...
Long-term home-based transcranial electrical stimulation for cognitive and motor function in older adults with an increased risk of dementia: a randomized controlled trial
Motoric cognitive risk (MCR) is a transition state between “normal” aging and Alzheimer’s disease and related dementias (AD/ADRD). Older adults with MCR have an increased risk of d...
Impact of developmental polychlorinated biphenyls on bladder contractility
Lower urinary tract symptoms (LUTS) impose a significant healthcare burden and reduce quality of life. This is especially true in individuals with Autism Spectrum Disorder (ASD) wh...
Mechanisms of cefiderocol nonsusceptibility and resistance evolution in carbapenem-resistant pathogens
PROJECT SUMMARY The continuing emergence and rapid dissemination of antibiotic-resistant pathogens are becoming a major threat to public health. Infections caused by carbapenem-res...
Contribution of vestibular dysfunction and its central multisensory integration to imbalance in aging
Project Summary The primary contributors to age-related imbalance remain poorly understood because nearly all contributors to balance deteriorate with age, including sensory inputs...
Investigating the Pathogenic Role of Tubulin Post-translational Modifications in CIPN
SUMMARY Chemotherapy induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of oral or intravenous chemotherapy. Approximately 50–90% of patients unde...
The role of acute excitation of sensory neurons in the development of paclitaxel-induced peripheral neuropathy
Project summary/Abstract: Paclitaxel-induced peripheral neuropathy (PIPN) and associated neuropathic pain is a significant adverse effect experienced by cancer patients who receive...
Redox Signaling and AMPK Crosstalk on Alcohol-Induced Multi-Organ Damage: Liver and Adipose TIssue
The goal of the application is to define the interaction among superoxide dismutase 1 (SOD1), adenosine monophosphate-activated protein kinase (AMPK), and catalase in modulating li...
Entropic Redistribution Drives the GRK-Independent Binding of Arrestin 2 to the Cannabinoid 2 Receptor
Contact PD/PI: Shriver, Thomas J. PROJECT SUMMARY Arrestins are an important class of secondary messenger proteins involved in signal transduction at G protein- coupled receptors (...