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606,025 grants found
Showing 29,541 – 29,560 of 606,025 grants
Dissecting Key Interactions of the HTT Transcription Coupled Repair Complex
Project Summary/ Abstract Huntington’s Disease (HD) is a devastating neurological disease with no available disease modifying therapies. Accordingly, there is a dire need to identi...
Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder
Project Summary Alcohol Use Disorder (AUD) contributes to 88,000 deaths per year in the United States. Although several pharmacological treatments are available, adherence to these...
Identifying Targets for Fall-prevention Rehabilitation in People with Parkinson’s Disease
PROJECT SUMMARY The long-term goal of this line of research is to improve physical therapy for fall prevention in people with Parkinson’s disease (PD). Falls place an enormous burd...
Multi-scale modulation of organ adaptation
Organs modulate their functions and forms to adapt to changing physiological needs and external stimuli. Current understanding of organogenesis revealed how molecules and cells wor...
A Mobile Web App Intervention to Promote Cervical Cancer Screening among Indigenous Women
Project Summary Our overarching goal is to increase the rates of cervical cancer (CC) screening among Indigenous women in the U.S. This population experiences disproportionately hi...
Imaging Cytometer
PROJECT SUMMARY/ABSTRACT The University of Iowa Flow Cytometry Facility was established in 1979 and currently serves 128 principal investigators spanning 31 departments across four...
Novel Econometric Research Designs (NERD) to Help End Addiction Long-term
PROJECT SUMMARY/ABSTRACT Opioid use disorder (OUD) is a public health emergency impacting the lives of an estimated 5.6 million individuals in the United States. OUD is a particula...
Surgical Oncology Research Training at Indiana (SORTI)
SUMMARY Surgeon-scientists are an underrepresented population in academic medicine, and federally funded physician- scientist-led research has been in decline over the past decade....
Electron Energy Filtering System for Cryo-EM Imaging
PROJECT SUMMARY Cryogenic electron microscopy (cryo-EM) is indispensable for structural biology studies. Arizona State University (ASU) has a long history of leadership in the elec...
A Multilevel Data Analytic Solution to Advance Population Cancer Research
Project Summary/Abstract The proposed work will develop a first-of-its-kind, transportable informatics tool, the Population Cancer Assessment and Surveillance Engine (Pop-CASE), th...
Mechanistic and Structural Studies of ERAD
Project Summary/Abstract Maintaining protein homeostasis– the delicate balance between protein synthesis, folding, and degradation– is essential for cellular health. Over a third o...
Integrating genomic and spatial insights on Mtb transmission into policy-relevant models
PROJECT SUMMARY/ABSTRACT Tuberculosis (TB) remains a leading cause of global mortality. Treatment is efficacious and low cost for most people, but clinic-based (“passive”) case det...
Modulation of Ventricular-Vascular Coupling in Veno-Arterial Extracorporeal Membrane Oxygenation
Project Summary/Abstract Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) use in acute myocardial infarction (AMI) is increasing exponentially. Despite this, mortality r...
Project 1: Role of DYNLL1 in the 53BP1 Axis of HDR Regulation
ABSTRACT Double stranded DNA break (DSB)s are repaired by two major mechanistically distinct pathways, DNA homology-directed repair (HDR) and non-homologous end joining (NHEJ). A d...
Project 2: BRCA1-dependent DNA End Resection and Regulation via the 53BP1 Axis
PROJECT SUMMARY/ABSTRACT DNA double strand breaks (DSBs) are induced by genotoxic agents such as ionizing radiation, chemotherapeutic agents, and during encounters of the DNA repli...
Detection and characterization of motor activity in behaving infants through the use of novel ultrasonic brain imaging technology
Abstract Recent advances in neuroimaging technology have significantly contributed to a better understanding of brain organization, and the development and application of more effi...
Long COVID Health Literacy Project: Bringing Health Information to Patients and Providers with Health Disparities in Rural Northern New England
The purpose of this project is to address health disparities in the care of patients with post-acute COVID syndrome (PACS) due to the rural nature of northern New England and its s...
Molecular mechanisms controlling tooth development
PROJECT SUMMARY Genetic diseases such as tooth agenesis, dentinogenesis imperfecta, infectious diseases such as caries or fractures represent common public health problems that aff...
Enhancing recovery of lower limb function after spinal cord injury
Spinal cord injury (SCI) is a debilitating neurological condition that impacts an estimated 250,000 individuals in the United States. Deficits in locomotion strongly contribute to...
Determining the roles of brain-derived neurotrophic factor (BDNF) and neuronal synchrony in the memory-enhancing effects of testosterone in the aging male brain.
PROJECT SUMMARY / ABSTRACT Cognitive decline is a common component of aging, and spatial memory is especially affected by old age. Testosterone levels among men decline steadily wi...