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606,025 grants found
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Expanding the Genetic Lexicon with Designer Genetic Alphabets
The project aims to explore how the rules of life’s genetic alphabet (A, T, G, C) can be generalized beyond four letters. Rather than the natural 4-letter alphabet, this project wi...
Conference: Developing Skills for Advanced Careers in Biology for NSF Postdoctoral Fellows in the PRFB Broadening Participation 2023 Cohort
This project supports a workshop for Postdoctoral Research Fellows in Biology, supported by the Broadening Participation of Groups Underrepresented in Biology track. The workshop i...
Planning: CRISES: Center for Indigenous Knowledge and Stewardship (CIKS)
Addressing national and global crises taking place at the intersection of society and environmental relations requires innovation and transformative approaches. Current approaches...
Structure of ancient solutions to Ricci and mean curvature type flows
Geometric flows are evolution equations that describe motions of surfaces, or their higher dimensional analogues, with speeds determined by their curvatures. Of significant interes...
REU Site: Opportunities for Undergraduate Research in Human Development and Family Sciences (OUR HDFS) Fellowship Program
This project is funded by the Research Experiences for Undergraduates (REU) Sites program in the SBE Directorate. It has both scientific and societal benefits and integrates resear...
Measuring Integration in Affordable Housing with Location Data
Moving people to 'better' places underpins the rationale for over 42 billion dollars in federal spending on flagship programs in affordable housing and social policy. Yet...
Collaborative Research: Transport Dynamics and Mobility of Large-Scale Submarine Volcaniclastic Density Currents at Hunga Volcano, Tonga
In January 2022, the largest submarine explosive volcanic eruption recorded by modern instruments occurred at Hunga volcano in Tonga. This research will collect samples and new obs...
Collaborative Research: Providing Engineering Community College Students Opportunities for Research, Leadership, Mentoring, and Community Development
This project aims to serve the national interest by preparing community college students for careers in engineering through participation in evidence-based experiential learning op...
Computability and the absolute Galois group of the rational numbers
The absolute Galois group Gal(Q) is well-known throughout mathematics. Its elements are precisely the symmetries of the algebraic closure of the rational numbers. In practice, thou...
Collaborative Research: Precipitation and Streamflow Reconstruction and Analysis in the Amazon River Basin
Tree ring reconstruction of paleoclimate in the tropics is challenging because tropical trees rarely have reliable annual banding. Consequently, the climate history of tropical are...
Innate immune roles of glycoRNA
PROJECT SUMMARY/ABSTRACT GlycoRNAs are newly discovered biopolymers that are comprised of small non-coding RNAs and a sialic- acid containing N-glycan. These RNAs decorate the mamm...
Circular RNAs in Cholestatic Liver Diseases
Primary sclerosing cholangitis (PSC) is a major cholestatic liver disease with high morbidity and mortality. Inflammation and fibrotic injury of the bile ducts due to impairment of...
CORE B: Data Management Core
The overarching goal of our research consortium, entitled "PROVIDENT: PRepositioning Optimized Vaccine strategies and Immunotherapeutics against Diverse Emerging iNfectious Th...
CORE C: Structure & Protein Engineering Core
For pandemic preparedness, structural biology and structure-based vaccine design are critical to the prototype pathogen approach. Vaccine developers must select the viral protein(s...
CORE D: Animal Models and In Vivo Evaluation Core
In vivo efficacy testing is essential for the down-selection, evaluation, and development of potent and effective medical countermeasures (MCMs), especially given that many aspects...
CORE E: RNA Manufacturing Core
PROJECT SUMMARY RNA vaccines have quicker development timelines and are simpler to manufacture than traditional vaccines. Combining this strength of RNA technology with protein eng...
Research Project 1: Discovery and dissection of virus-host interactions and pathogenetic mechanisms
Viruses interact with and hijack a vast array of cellular molecules and pathways to facilitate their multiplication and spread, while also reprograming infected cells to release pa...
Research Project 2: Antigen design and immunological evaluation
In Project 2 (P2) we will use cutting-edge antigen engineering to refine vaccine antigen design strategies through iterative assessments of immunogenicity and protective efficacy t...
Research Project 3: Rapid-Response Roadmap for RNA vaccines
Abstract RNA vaccines have dramatically altered the landscape of vaccine development, affording an unparalleled ability to rapidly counteract emerging infectious diseases, as evide...
Research Project 4: Mining human antibody responses to inform vaccine and therapeutic design
Abstract: This proposal embodies the development of an advanced platform for rapid identification, characterization, and optimization of monoclonal antibodies (mAbs) to effectively...