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606,025 grants found
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Defining the molecular basis controlling hematopoietic stem cell symmetric and asymmetric divisions
PROJECT SUMMARY AND ABSTRACT Hematopoietic stem cells (HSCs) maintain blood homeostasis through a delicate balance in fate choices of self-renewal and commitment to differentiation...
Human genetic studies to solve the etiology of congenital obstructive uropathy and its subphenotypes
Congenital anomalies of the kidney and urinary tract (CAKUT) represent highly understudied conditions, but have tremendous impact on patient morbidity and mortality. Among CAKUT ca...
Leveraging a unique dog model to determine the role of uromodulin in kidney stone disease
Kidney stones are a painful and common health problem, occurring in 8-12% of the population. Most kidney stones are composed of calcium oxalate (CaOx). Current therapies to prevent...
Balancing motivation through VTA GABA/Glutamate co-transmission
Project SummaryUpdates: I am moving to a new position at Dartmouth College as an independent, tenure-track Assistant Professor in the Department of Psychological and Brain Sciences...
Neonatal Stress in Very Preterm Infants: Longitudinal Effects on Epigenetics and Neurodevelopment
PROJECT SUMMARY (See instructions): Preterm birth affects 1 in 10 infants born in the United States, resulting in significant morbidity and economic cost. Children who are born ver...
ACTIVE MIND: An adaptive clinical trial of cognitive training to improve function and delay dementia
PROJECT SUMMARY Dementia such as Alzheimer's disease (ADRD) is the most expensive medical condition20 in the US and affects more than 5 million Americans21. Analyses from the...
Mentorship in Clinical Complementary and Integrative Health Research
Because over 50% of adults in the United States take complementary and integrative health (CIH) natural products for their health, the training of CIH practitioners and scientists...
Mechanistic investigation of therapies for Down Syndrome Regression Disorder
PROJECT SUMMARY. Down syndrome (DS), the genetic condition caused by trisomy 21 (T21), is a leading cause of intellectual and developmental disability, with an estimated prevalence...
Federated Learning Framework for Multimodal Survival Analysis in Pediatric Cancers
Overall Summary/Abstract Childhood cancers, although rare, significantly impact thousands of children globally each year. The complexity and variability of these cancers necessitat...
SARS-CoV-2 Serological Antibody Testing for Disease Surveillance and Clinical Use
Abstract Serologic testing for presence of SARS-CoV-2 antibodies is a critical tool for understanding the epidemiology and designing control strategies for the COVID-19 pandemic. O...
3D Shearwave Elasticity Biomarker Development for Neuromuscular Disease
Elasticity imaging techniques generate quantitative measurements of the biomechanical properties of tissue that serve as biomarkers for disease presence as well as enabling the cha...
α-Synuclein Regulation of the Erythroid Iron Restriction Response
(PLEASE KEEP IN WORD, DO NOT PDF)The erythroid iron restriction response suppresses erythropoiesis during iron deprivation and leads to iron deficiency anemia (IDA), one of the mos...
Role of UPR transducer Xbp1 in Pancreatic Beta Cell Survival and Function under Metabolic Stress
Diabetes is now a global epidemic. More than 95% of diabetes is type 2 diabetes (T2D), a chronic disease that can cause serious complications, including heart attack, stroke, kidne...
Tulane University COVID Antibody and Immunity Network (TUCAIN) Supplement
ABSTRACT The SARS-CoV-2 virus, the causative agent of COVID-19, has infected a reported 13,810,247 persons globally as of July 16, 2020 with a mortality rate of 4.2%. In the State...
A Data Resource for Blood and Marrow Transplants and Adoptive Cellular Therapy Research
PROJECT SUMMARY / ABSRACT CIBMTR (Center for International Blood and Marrow Transplant Research) represents an international network of >360 treatment centers and maintains a cl...
ECHO Coordinating Center (CC) - Administrative Supplement
Project Summary: To address knowledge gaps involving the impact of environmental exposures on health outcomes in children, the Environmental influences on Child Health Outcomes (EC...
Neurobiological Basis of Reference Frame Coordination for Spatial Memory to Action Transformations
PROJECT SUMMARY/ABSTRACT Guiding movements through space and establishing enduring memories based on such experiences is essential for the survival of all animals including humans....
Experimental Studies of Endoscopic Third Ventriculostomy and Choroid Plexus Cauterization in Hydrocephalus
Hydrocephalus (HC) is a common and debilitating neurological condition affecting up to 1 in 500 individuals. Ventriculoperitoneal shunting (VPS) has been the standard treatment for...
Targeting regenerative reprogramming in colorectal cancer
ABSTRACT Poorly defined fitness features enable a subset of cancer cells to survive therapy, ultimately giving rise to treatment-refractory tumors. The expanded use of sequencing t...
Health Disparities in Alzheimers and Related Diseases
This application from Florida International University (FIU) and Emory University requests support for a four-year research conference series to address critical scientific issues...