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606,025 grants found
Showing 28,821 – 28,840 of 606,025 grants
Discovery of Novel Therapeutic Strategies for Cancer Immunotherapy
Project Summary The central hypothesis of my F99-phase proposal is that the lack of T-cell infiltration into human tumors may be caused by the presence of tumor-derived T-cell excl...
IMAT-ITCR Collaboration: Multiplexed Spatial Data Calibration and analysis using micro-capsules
Project summary A major goal of cancer research is to define the composition of the tumor micro-environment (TME) across individuals. Once measured, differences in TME composition...
Cr(VI) exposure and skeletal muscle differentiation and regeneration
SUMMARY Hexavalent chromium, Cr(VI), is widely used in industrial processes such as stainless steel production, electroplating, textile manufacturing, wood preservation, and leathe...
Elucidating the role of the hyaluronan matrices on the establishment of ovarian reserve and aging
ABSTRACT In mammals generally, including humans, the ovary ceases its functions little more than halfway through a female's lifespan. This is strikingly different from the cha...
Reversing disrupted developmental sterol biosynthesis by prescription medications
Compound heterozygous mutations of the DHCR7 gene give rise to a developmental disorder known as Smith- Lemli-Opitz syndrome (SLOS). The loss of DHCR7 function in these patients di...
Pathogenesis of oral microbes triggered by the cyclic deformation of biomaterials
PROJECT SUMMARY Oral pathogenic biofilms are major drivers of major oral infectious diseases such as dental caries and denture stomatitis. Currently, the annual cost of treatment o...
FullMouth: Enhancing Dental Clinical Data and Reducing Disparities through Innovative ML Approaches.
Project Abstract/Summary The vast amount of health data created in the United States may hold the key to understanding disease, improving quality, and lowering healthcare costs. El...
IMAT-ITCR Collaboration: Engineering model-based systems to monitor and steer subclonal dynamics
PROJECT SUMMARY Ongoing cancer genomic studies have documented numerous mutations across all tumor types. Most cancer mutations have not been functionally characterized, as conduct...
Neural mechanisms of sensory over-responsivity in children with and without ASD
PROJECT ABSTRACT Sensory over-responsivity (SOR), or strong negative reactions to and avoidance of innocuous sensory stimuli, affects about one in five school-age children and abou...
Vascular sympathetic neurons in brown adipose tissue and systemic metabolism
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Cold exposure increases thermogenesis in brown a...
ZnT8-specific bioanalytical tools for probing autoimmune destruction of pancreatic beta-cells in type-1 diabetes
Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text.Type-1 diabetes is a chronic autoimmune disease...
Extracellular Matrix Adaptation to Exercise within MoTrPAC
PROJECT SUMMARY The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is generating a vast multi-omic, multi- tissue, multi-species dataset. With these data, the Cons...
Resolving the mechanism of osteoclast multinucleation and signaling in bone remodeling
PROJECT SUMMARY: Essential, life-long bone remodeling is coordinated by osteoclasts (OCs) that resorb old bone and osteoblasts that deposit new bone. Elevated OC formation/function...
A brief, task-shifted treatment to improve father depression and child outcomes in Kenya: A pilot effectiveness-implementation trial
PROJECT SUMMARY Globally, depression is the leading cause of disability world worldwide, yet over 75% of people in low and middle-income countries (LMIC) do not receive treatment....
Exploring the Collaborative Cross resource to identify different phenotypes of Lyme neuroborreliosis and disease-contributing genetic factors
PROJECT SUMMARY Lyme disease (LD), the most prevalent tick-borne illness in the US (~300,000-475,000 annual cases), is caused by spirochetes of Borreliella burgdorferi (Bb) sensu l...
RNA editing controls pulmonary endothelial pathophenotypes in pulmonary hypertension
ABSTRACT The primary objective of this proposal is to generate a scientific discovery program in pulmonary vascular disease to ensure a robust pathway for Dr. Woodcock to develop i...
The Diabetes Clinical outcomes Associated with Retention and Engagement in Care, in Samoa (Diabetes CARE)
Project Summary This proposal presents a five-year research career development award for Dr. Anna Rivara, an Associate Research Scientist (Yale's equivalent to Assistant Profe...
Developing a Two-way SMS Platform to Prevent and Treat Wasting Among HIV-infected and HIV-exposed Uninfected Children
PROJECT SUMMARY/ABSTRACT Twenty-five percent of children with HIV-infection have childhood wasting (low weight-for-height or low mid-upper arm circumference, and HIV-exposed uninfe...
The role of the transcriptional repressor ZEB2 in human neural crest cell formation and craniofacial pathology
Project Summary The objective of this proposal is to delineate the role of the transcriptional repressor ZEB2 during human neural crest cell formation, craniofacial differentiation...
Mechanisms of Impaired Epithelial Regeneration and Fibrosis After Silica Dust Inhalation
PROJECT SUMMARY Silicosis and asbestosis are progressive fibrotic lung diseases causing respiratory failure. Effective therapies are inadequate in large part due to our limited und...