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606,025 grants found
Showing 28,881 – 28,900 of 606,025 grants
Chromatin and immune regulation of tumor growth and progression
PROJECT SUMMARY Lung and pancreatic ductal adenocarcinomas are often diagnosed at very late stages of tumor progression when they are most aggressive and difficult to treat. Curren...
Developing and Testing Warning Labels for Retail Cannabis Products
PROJECT ABSTRACT Despite the legalization of retail cannabis (i.e., non-medical, “recreational”) in multiple states, there are still no federal regulations for warnings on cannabis...
HeartShare DeCODE-HF: Data translation center to Combine Omics, Deep phenotyping, and Electronic health records for Heart Failure subtypes and treatment targets
Title: Extraction of SDOH elements from multisite EHR for endorsed CDE mapping and analysis: HeartShare Project Summary: Heart failure with preserved ejection (HFpEF) is a highly p...
Interdisciplinary research training in maternal and childhood pain
PROJECT SUMMARY/ABSTRACT There is considerable societal need to better understand neurobiological mechanisms, psychosocial processes, treatments, preventions, and policy in child a...
Targeting Oxidized PTP1B for Anticancer Drug Discovery
PROJECT SUMMARY PTP1B, a non-receptor–type oncogenic PTP, also known as PTPN1, is involved in growth factor signaling. The PTP1B gene is frequently amplified in cancers and correla...
Regulation of synaptic activity by mRNA methylation
PROJECT SUMMARY Neurotransmitter release at synaptic terminals is tightly controlled, and its dysregulation has profound consequences for neural circuit activity and disease. Here,...
A Chemical Strategy for Imaging and Manipulating the Brain's Astrocytes
PROJECT SUMMARY The active participation of the brain’s astrocytes in normal and pathological brain function is now well established. Astrocytes adjust synaptic strength, mediate s...
Identifying New Therapeutics and Molecular Mechanisms in Congenital Disorders of Glycosylation.
Glycosylation is an essential biological pathway that involves the post- or co-translational addition of sugar moieties to proteins. Congenital Disorders of Glycosylation (CDGs) ar...
AI-directed discovery of heparanase inhibitors
(PLEASE KEEP IN WORD, DO NOT PDF)Heparanase, an endo-β-D-glucuronidase, is the only known enzyme to cleave the heparan sulfate (HS) side chains of heparan sulfate proteoglycans (HS...
Natural language processing and medical imaging analysis for multi-modality computer assisted diagnosis of ophthalmic diseases
PROJECT ABSTRACT No change since original proposal
Developing and Evaluating Multi-Modal Clinical Diagnostic Reasoning Models for Automated Diagnosis Generation
PROJECT ABSTRACT Diagnostic errors affect 12 million patients in the U.S. and contribute to 80,000 deaths per year. The main causes for diagnostic errors include cognitive biases i...
Cancer Center Administration
Project Summary/Abstract: Administration Norris Cotton Cancer Center (NCCC) Administration bridges the Geisel School of Medicine at Dartmouth College (Geisel) and Dartmouth-Hitchco...
Cancer Research Career Enhancement
Project Summary/Abstract: Career Enhancement Norris Cotton Cancer Center (NCCC) is a central provider and resource of Career Enhancement activities for its trainees, Program Member...
Biostatistics and Bioinformatics (BBSR)
Project Summary/Abstract: Biostatistics and Bioinformatics The Biostatistics and Bioinformatics Shared Resource (BBSR) offers comprehensive statistical and bioinformatics consultat...
Clinical Pharmacology (CP)
Project Summary/Abstract: Clinical Pharmacology The Clinical Pharmacology (CP) Shared Resource is in its 24th year of operation and supports Norris Cotton Cancer Center (NCCC) inve...
Genomic and Molecular Biology (GMB)
Project Summary/Abstract: Genomics and Molecular Biology The Genomics and Molecular Biology (GMB) Shared Resource provides advanced genomics technologies, services, and expertise i...
Immune Monitoring and Flow Cytometry (IMFC)
Project: Summary/Abstract: Immune Monitoring and Flow Cytometry The Immune Monitoring and Flow Cytometry (IMFC) Shared Resource, also known as DartLab, arose from the fusion of imm...
Liver fibrosis cell-based assay platform: integrating patient-derived fibrotic liver ECM with primary stellate cells, Kupffer cells, and hepatocytes to accelerate anti-fibrotic drug development
PROJECT ABSTRACT Xylyx is developing engineered human liver fibrotic lesions as a predictive cell-based assay platform to address the lack of in-vitro drug testing assay products c...
Mouse Modeling (MM)
Project Summary/Abstract: Mouse Modeling Mice are by far the most commonly used vertebrate research model organism for biomedical research, and the ability to generate efficiently...
Pathology (PSR)
Project Summary/Abstract: Pathology The Pathology Shared Resource (PSR), a designated Norris Cotton Cancer Center (NCCC) Shared Resource facility, was created to provide NCCC inves...