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606,025 grants found
Showing 28,721 – 28,740 of 606,025 grants
A Novel Blood Substitution Approach Treats Acute Ischemia in the Aged Brain
Project Summary/Abstract Aging is associated with a striking increase in the incidence of stroke, which is a major cause of disability among those aged 65-years and older. Effectiv...
Engineering an extracellular vesicle-based targeted regenerative nanotherapeutic for multiple sclerosis
ABSTRACT Multiple sclerosis (MS) is an autoimmune disease that gives rise to chronic neurological deficits. It is caused by an immunological attack on the myelin sheath leading to...
Pharmacokinetics (PK) and Pharmacodynamics (PD) Characterization of mTOR Inhibitors in Older Adults
Abstract Aging is the time-dependent functional decline responsible for increased susceptibility to chronic disease, frailty, and disability. Aging is a substantial public health c...
Impact of Wildfire Smoke on Lung Injury
ABSTRACT The US Environmental Protection Agency recognizes wildfire smoke as a significant source of particulate matter under 2.5 microns diameter (PM2.5) emissions, which are expe...
Programmable Phage Display Peptidomes to Characterize Uveitis
PROJECT SUMMARY/ABSTRACT Uveitis is a heterogenous group of ocular inflammatory diseases that results in significant ocular morbidity and can cause long-term blindness if not diagn...
Extensively drug resistant Pseudomonas aeruginosa keratitis outbreak strain: virulence mechanisms and mitigation
Project Summary / Abstract The recent outbreak of keratitis caused by an extensively drug-resistant (XDR) strain of Pseudomonas aeruginosa with blaVIM-80 and blaGES-9 associated wi...
Defining Sexual Dimorphism in the Skin
Defining Sexual Dimorphism in the Skin The skin executes many functions differently based on biological sex. Nevertheless, the cellular and molecular mechanisms that give rise to t...
Liposome-crosslinked hyaluronic acid hydrogels with localized protein delivery for myocardial infarction therapy
Myocardial infarction (MI) is a leading cause of death in the United States, affecting over 800,000 people annually. Numerous protein therapies have been developed to treat MI, but...
Integrative 'omics for biomarkers and biology of early-stage heart failure
ABSTRACT Early-stage heart failure (HF), defined broadly as asymptomatic structural heart disease, is a growing public health concern and has been receiving greater attention in cl...
Investigating the role of SPRR1A in border zone cardiomyocytes during neonatal cardiac repair
PROJECT SUMMARY/ABSTRACT Myocardial infarction (MI) causes localized cardiomyocyte (CM) death which predisposes the adult mammalian heart to persistent fibrosis and subsequent comp...
Input specific adaptations to glutamatergic strength and plasticity on PFC PV-INs following ethanol drinking
Project Summary/Abstract: Although both men and women are affected by alcohol use disorder (AUD), women often progress through AUD disease milestones faster and experience more sev...
Improving Cultural Competency Across the Mental Healthcare Delivery Network
Project Summary/Abstract: Improving Cultural Competency Across the Mental Healthcare Delivery Network. The American Psychiatric Association (APA) is requesting an Agency for Health...
3D Spatial Multi-Omics Profiling of Ovarian Cancer
Research Summary: High-grade serous ovarian cancer (HGSOC) is the most common histologic subtype of ovarian cancer. Despite ongoing efforts to develop effective surgical and treatm...
Integrated Stress Response-mediated macrophage innate immunity during maladapted Salmonella enterica infection
ABSTRACT Infection induced host cell stress underlies many host-pathogen engagements, yet the mechanisms by which host cell stress influences the innate immune response to infectio...
Addressing biases and evaluating gender differences in lifecourse obesity and risk of ADRD in a diverse cohort
PROJECT SUMMARY (ABSTRACT) With an increasingly aging and diversifying US population, the prevalence of Alzheimer’s Disease and related dementias (ADRD) is expected to rise. The ex...
Dissecting the role of ZCWPW1 in oocyte quality, fertility and ovarian physiology.
PROJECT SUMMARY: Gametogenesis relies on a specialized cell division called meiosis, where homologous chromosomes pair together, exchange genetic information through induced DNA do...
Formation and Regulation of Meiotic Crossovers
PROJECT SUMMARY Diploid organisms, including humans, create haploid gametes for sexual reproduction through the specialized cell division program of meiosis. For meiosis to occur s...
Biosynthetic Development and Diversification of Moroidin Peptides for Cancer Applications
PROJECT SUMMARY Macrocyclic peptides are effective scaffolds for cancer drug discovery because they can combine the metabolic stability and target specificity of biologics with ora...
Investigating invariant motion encoding in mouse visual cortex
PROJECT SUMMARY A fundamental feature of perception is the ability to recognize objects or object features despite changes in presentation, such as size, position, or context. Eluc...
Mechanisms and discovery of small-molecule effectors targeting cardiac ion pumps
PROJECT SUMMARY/ABSTRACT The overarching goal of our proposed research is to determine the mechanisms underlying small-molecule activation of the cardiac calcium pump (sarcoplasmic...