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606,025 grants found
Showing 28,741 – 28,760 of 606,025 grants
Center for Human Lymphoma Spatiotemporal Atlas (HuLymSTA)
SUMMARY Non-Hodgkinlymphomas (NHL) represent about 90% of all lymphomas diagnosed each year and is classified based on cell type - B cell, T cell and natural killer (NK) cell types...
Center for Gastric Pre-Cancer Atlas of Multidimensional Evolution in 3D (GAME3D)
PROJECT SUMMARY This application aims to address the urgent need for precision in intercepting hereditary diffuse gastric cancer (HDGC) associated with pathogenic germline CDH1 mut...
Intimate Partner Violence and Depression Trajectories from mid-Adolescence to Young Adulthood
PROJECT SUMMARY Intimate partner violence (IPV) and depression are substantial public health challenges for U.S. adolescents, and evidence suggests a clear link between IPV experie...
Mechanisms of osmosensing in GI enteroendocrine cells
PROJECT SUMMARY/ABSTRACT The gastrointestinal (GI) epithelium directly senses components of foods we eat, which contain a variety of nutritive and non-nutritive stimuli. These stim...
A Multimodal 3D Atlas of Colorectal Cancer Across Ages of Onset
PROJECT SUMMARY We propose the construction of a three-dimensional (3D) multimodal molecular atlas of colorectal cancer (CRC) across different ages of onset of the disease. We aim...
High-throughput experimental and computational identification of RNA elements that regulate trafficking to midbodies
PROJECT SUMMARY / ABSTRACT Subcellular mRNA localization enables post-transcriptional regulation of gene expression through the spatial and temporal control of translation. Control...
Human Prostate Tumor Atlas Center
Project Summary Earlier gains in reducing prostate cancer (PCa) mortality, partially due to advances in screening and the use of androgen deprivation therapy to treat metastatic PC...
Pre-cancer atlas of skin cancer
The overarching goal of our proposal is to develop a pre-cancer atlas of skin cancer. Skin is an ideal model to study the early phases of tumorigenesis because it is easily accessi...
Alpha-catenin phosphorylation is mechanosensitive and required for epithelial barrier structure-function
PROJECT SUMMARY Intercellular adhesion is essential for tissue development and maintenance. One such adhesive structure is the zonula adherens junction (ZA) where the tension sensi...
Cannabis use, trauma, and self-regulatory cognitive processes: A multimodal study integrating biobehavioral markers and ecological assessment
PROJECT SUMMARY/ABSTRACT Cannabis use (CU) to manage mental health symptoms is increasing in both clinical and recreational contexts, particularly among young adults. This emerging...
Structural and functional integrity of antigen receptors
Abstract Antibodies play a pivotal role in the adaptive immune system due to their ability to specifically bind to a diverse array of antigens. There are two structurally diverse f...
Genome-wide approaches to non-invasive screening and characterization of ovarian cancers
PROJECT SUMMARY Ovarian cancer is the deadliest gynecological cancer, in part because there is no widely used screening test and 80% of tumors are diagnosed at a late stage. Though...
AI-enabled characterization of fibrocalcific aortic valve disease and inflammation from CT Angiography: Patient-specific outcome prediction
PROJECT SUMMARY Aortic stenosis (AS)—narrowing of the aortic valve—is the most common heart valve disease. Degeneration of leaflets in AS leads to valvular obstruction, thickening...
An atlas of pancreatic tumorigenesis in the context of altered DNA repair occurring in high-risk individuals
PROJECT SUMMARY/ABSTRACT Pancreatic Ductal Adenocarcinoma (PDAC) is on track to become the second leading cause of cancer related deaths in the United States. This dismal prognosis...
Developing a Chemically-Controlled RAS Toolset
Project Abstract RAS GTPase operates as a molecular switch toggling between GDP-bound (inactive) and GTP-bound forms (active), and orchestrates dynamic cellular processes such as p...
Understanding the role of tumor microenvironment in low grade glioma progression to malignancy
ABSTRACT Our PCA research center brings together the UCLA Neurosurgery team with the Caltech spatial single cell team to construct a comparative spatial atlas of low-grade gliomas....
Transcranial Electrical Stimulation in Stroke EaRly After onset Clinical Trial-2 (TESSERACT 2)
Acute ischemic stroke (AIS) is a leading cause of death and disability for which treatments are limited to reperfusion therapies, including intravenous thrombolytic (lytic) and end...
The Impact of Third Trimester Alcohol Exposure on Memories Encoded by Sharp-Wave Ripples of the Hippocampal-Retrosplenial Cortex Circuit
Project Summary Fetal alcohol spectrum disorder (FASD), which occurs when a fetus is exposed to alcohol, is a neurodevelopmental disorder affecting up to 5% of the US population. O...
The Aging Pancreas as a Pro-tumorigenic Niche
PROJECT SUMMARY Age is a major risk factor for pancreatic ductal adenocarcinoma (PDAC), with the incidence of PDAC rising sharply with increasing age. Most PDAC cases occur in indi...
Integrating tuberculosis treatment into community pharmacies to improve TB/HIV outcomes in Uganda.
PROJECT SUMMARY/ABSTRACT The overall objective of this K43 Emerging Global Leader Award is to support Dr. Jonathan Izudi’s transition to independence as an implementation scientist...