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606,025 grants found
Showing 28,701 – 28,720 of 606,025 grants
A multimodal examination of functional network health and its relationship with tau deposition
Abstract Alzheimer’s disease (AD) affects millions of people worldwide, and its prevalence is expected to increase dramatically in the coming years. Although some people are resili...
Research and Mentoring in the Clinical Epidemiology and Health Disparities of Cardiovascular Diseases and Hypertension
PROJECT SUMMARY Cardiovascular disease affects nearly half of all American adults. Achieving cardiovascular health is associated with lower mortality and morbidity, but modifying a...
Bifunctional Inhibitors of STING as Chemical Probes for Diabetic Retinopathy
PROJECT SUMMARY More than 40% of patients with diabetic retinopathy (DR) are refractory to direct intraocular injection of anti- VEGF antibodies, the standard of care. The inabilit...
Addressing Disparities in Out-of-Hospital Cardiac Arrest: Utilization of Health-Related Social Needs and Predictive Analytics to Improve Clinical Outcomes
PROJECT SUMMARY The overarching goal of this K08 research project is for Dr. Ethan Abbott, principal investigator (PI), to establish himself as an independent physician-scientist w...
Evolution of B Lymphocyte Insulin Autoantigen Recognition in Type 1 Diabetes
PROJECT SUMMARY Insulin-binding B lymphocytes contribute to type 1 diabetes (T1D) through B cell receptor (BCR) recognition of insulin and autoantigen presentation to T lymphocytes...
Therapeutic Targeting of Adult Hippocampal Neurogenesis in a Mouse Model of FASD
PROJECT SUMMARY The overall goal of the proposed research is to determine the effect of pharmacological, genetic, or activity - based intervention to restore the neurogenic respons...
Transcriptional and Developmental Basis of the Human X-linked Homeotic Hotspot
Abstract Human eye development is an exquisitely balanced crosstalk of numerous signaling pathways that iteratively dictate the ebb and flow of this complex and highly physiologica...
Radiation and dendritic cell combination to improve immunotherapy response in intrahepatic cholangiocarcinoma
Summary Intrahepatic cholangiocarcinoma (iCCA), the second most common primary liver cancer after hepatocellular carcinoma (HCC), is an aggressive malignancy with dismal overall pr...
Examining the modulatory role of galanin in opioid reward
PROJECT SUMMARY The opioid epidemic in the United States has reached critical proportions, with opioid-related overdoses contributing to more than 75% of drug overdose deaths. This...
A single prime editing strategy for correcting diverse mutations responsible for RBM20-associated dilated cardiomyopathy
PROJECT SUMMARY Familial dilated cardiomyopathy (DCM) is a heritable disorder characterized by progressive enlargement of the heart’s ventricles and impaired contraction, leading t...
Chronic MitoQ Supplementation for Improving Cerebrovascular Function in Older Adults
PROJECT SUMMARY/ABSTRACT The purpose of this Ruth L. Kirschstein National Research Service Award is to provide support for Ms. Sanna Darvish, a PhD student in Dr. Douglas Seals’ la...
The Impact of Shear Stress on Aquaporin 1 Expression in the Pulmonary Endothelium
PROJECT SUMMARY Pulmonary endothelial cells (ECs) are in direct contact with laminar blood flow, resulting in exposure to shear stress. Normal blood flow provides a physiologic deg...
Explicit, Vicarious and Internalized Racial Discrimination on Daily Associations and Long-Term Health Trajectories among Filipino, Korean, and Indian Americans
ABSTRACT The alarming 339% increase in the incidence of explicit racial discrimination (e.g., threats, unfair treatment due to one’s race) experienced by Asian Americans since the...
Stromal targeting to improve the efficacy of systemically administered drugs for pancreatic ductal adenocarcinomas
Project Summary Only about 20% of pancreatic ductal adenocarcinoma (PDAC) patients are expected to survive one year from diagnosis, with the overall 5-year survival rate reported a...
Development of a novel survey to screen for chemotherapy-induced peripheral neuropathy in young children
PROJECT SUMMARY/ABSTRACT This application is developed to support Rozalyn Rodwin, MD, MHS, a current Assistant Professor in Pediatric Hematology-Oncology at Yale School of Medicine...
Autoimmune Basis of Acquired Lipodystrophies
Obesity remains a major health problem in US and causes metabolic complications such as diabetes, dyslipidemia and insulin resistance. Similar complications also occur in patients...
Defining the onset and regulation of myogenic upper urinary tract physiology
AbstractImpaired urinary outflow that causes damage to the urinary tract and kidney is a major cause of kidney disease, which affects 15% of the population and costs $100B annually...
Decreasing Cardiometabolic Risk in Survivors of Childhood Cancer: Survivors engaged in Time-Restricted EatiNG after THerapy (STRENGTH)
PROJECT SUMMARY Over 500,000 survivors of childhood cancer are living in the United States today. Cardiovascular disease is the leading cause of noncancer late mortality in this co...
Compartmentalized cAMP signaling in reactive astrocytes
PROJECT SUMMARY Glaucoma is the leading cause of irreversible blindness and along with other optic neuropathies is characterized by the loss of retinal ganglion cells (RGCs). Incre...
Molecular Mechanisms Underlying Luminal- Neuroendocrine Transdifferentiation
Summary The objective of this proposal is to determine the molecular mechanisms underlying luminal-to-neuroendocrine transdifferentiation (NET) of prostate cancer (PCa). NET underl...