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606,025 grants found
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Intersection of cytoskeletal regulation with tumor cell metabolism
SUMMARY Pancreatic cancer (PDAC) is particularly lethal, due in part to a resistance to therapies and a high incidence of metastasis. The overall goal of our research program is to...
Defining pro-metastatic drivers in the pancreatic cancer tumor microenvironment
PROJECT ABSTRACT Pancreatic adenocarcinoma (PDAC) is an almost uniformly fatal disease most often diagnosed after the development of metastases. The tumor suppressor gene, TP53, is...
Epigenetic Aging Cognitive Function and Exercise in Older Adults
Abstract In the United States, 1 in 9 individuals 65 and older and one third of individuals 85 and older have Alzheimer’s dementia (AD). By age 70, age-related cognitive decline is...
IRS2 and mitotic regulation in breast cancer
Project Summary The overall goal of this proposal is to determine the mechanism by which Insulin Receptor Substrate 2 (IRS2) regulates the spindle assembly checkpoint (SAC) and to...
The recruitment and retention of colon intraepithelial lymphocytes
Project Summary An intact epithelial barrier is key for maintaining intestinal homeostasis and preventing inflammation. Barrier dysfunction has been associated with inflammatory bo...
Human Genetic Approach for UTI Points to Novel Immune Defense Cells of the Kidney Epithelia
Project Summary / Abstract Urinary tract infections (UTI) affect 13.3% of women and 2.3% of men annually with a high rate of recurrence. Infection can be localized to the bladder (...
Northwest Comprehensive Research Training in Kidney, Urologic, and Hematologic Sciences (NCOR-KUH)
ABSTRACT FOR THE OVERALL U2C/TL1 APPLICATION Kidney, urologic and hematologic (KUH) diseases are significant public health issues affecting the U.S. population. Yet, the KUH scient...
Interrogating the protective effect of African APOE alleles on Alzheimer's disease risk through pleiotropy
Project Summary/Abstract Alzheimer’s disease (AD) is a highly heritable trait, where much of the phenotypic variation is explained by genetic variation. A significant proportion of...
Returning AD biomarker Results to Community Dwelling Older Adults: Testing Modalities and Impact
Project Summary This study will develop a process to return Alzheimer Disease (AD) biomarker research results and will evaluate whether the results can be sent directly to particip...
Cellular Senescence in Trisomy 21 lung disease
SUMMARY Trisomy 21 (T21) occurs in ~1 in 700 live births resulting in Down Syndrome (DS), where pulmonary complications are the main cause of hospitalizations in children and adult...
Hyperpolarized 13C MRI of Cardiac Metabolic Remodeling in Heart Disease
Project Summary Abnormalities in cardiac energy metabolism and mitochondrial dysfunction have been implicated in numerous heart diseases such as hypertrophic cardiomyopathy (HCM),...
Influence of microglial cell depletion and repopulation on aducanumab induced ARIA and vascular lesions in APOE4 carriers with AD
After many failed clinical trials, the FDA recently approved new breakthrough antibody therapy for use in early AD. But thesetherapies have been revealed to increase the frequency...
Mechanisms Driving the Rapid Evolution of Cancer Genomes
PROJECT SUMMARY/ABSTRACT The goal of this proposal is to identify the mechanism of catastrophic mutational processes that drive very rapid evolution of cancer genomes. One of these...
Molecular basis of cell-cycle plasticity and robustness
Project Summary The mammalian cell cycle is commonly conceived as a well-understood, hardwired, invariant pathway. Emerging work, however, indicates that the cell cycle is much mor...
Development of a real-time interactive PET/US imaging technology to enhance theranostics applications in precision medicine
Project Summary / Abstract This project will develop a novel molecular imaging technology that combines positron emission tomography (PET) and ultrasound (US) imaging to enable int...
Investigating an African American-specific APOE genetic variant using hiPSC
PROJECT SUMMARY ABSTRACT African Americans are at a significantly elevated risk of Alzheimer’s disease (AD) compared to the non-Hispanic white population. Yet, the underlying mecha...
Examining the Impact of Peroxisomal Fission on Cell Fate Decisions During Neurodevelopment
PROJECT SUMMARY Zellweger spectrum disorders (ZSDs), which affect 1:50,000 individuals in the U.S., are characterized by dysfunction in any one of 13 peroxisomal biogenesis protein...
Treatment Utilization During Community Reentry of Opioid Use Disorder Inpatients
Project Summary/Abstract Nearly 400,000 people with an opioid use disorder (OUD) receive OUD treatment each year (19.7% of all people with an OUD). Community re-entry following res...
Neural Correlates of Spatial Attention Deployment and Perceptual Decision Making
PROJECT SUMMARY Each of the 4-5 quick eye movements (saccades) that we generate every second is the result of a target selection process that combines perceptual and motor planning...
Role of EphA1/A2 domain-domain and -membrane interactions for receptor specificity and Blood Brain Barrier dysfunction
Ligand activation of Eph receptors plays a decisive role in cell migration during blood vessel formation and neuronal axon guidance. Eph receptors can also signal independently of...