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606,025 grants found
Showing 28,661 – 28,680 of 606,025 grants
Redirected CaMKII for restoring deficits in Alzheimer's disease models
PROJECT SUMMARY/ABSTRACT Alzheimer's disease is a progressive, degenerative brain disease. The major symptoms are impairments in memory and cognitive functions. These changes...
Sex and gender influences on inflammation and pain in sickle cell disease
PROJECT ABSTRACT Females with sickle cell disease (SCD) in the United States face a health disparity triple threat as a result of their chronic disease, race, and sex. In addition...
Inflammatory Caspase Activation in Sickle Cell Disease
PROJECT SUMMARY/ABSTRACT Sickle cell disease (SCD) is an inherited red blood cell disorder that impacts millions of people worldwide. Patients with SCD undergo chronic hemolysis wh...
Participatory System Dynamics to Enhance PrEP Access for Black and Latinx Sexual Minority Men in Bronx, NY
ABSTRACT Black and Latinx sexual minority men (BLSMM) in the Bronx, NY and in the U.S. overall are among the populations most impacted by HIV in both Bronx, NY and in the U.S. BLSM...
Multidimensional Correlates of Atherosclerotic Resilience in Rural Communities
PROJECT SUMMARY At least 60 million (one in every five) Americans live in rural areas, among whom harbor a disproportionately high burden of cardiovascular disease (CVD). The worse...
Clarifying phenotypes of suicide risk in preteen youth: An intensive longitudinal assessment study
PROJECT ABSTRACT Suicide risk is increasing in preteens, 8-12-years old. Although research is limited, it is estimated that 15% of preteens in community samples and 43% in clinical...
Wiring and rewiring of the chromatin landscape during retinogenesis
SUMMARY: The proper execution of transcriptional programs in retinal progenitor cells is extremely critical for retinal formation as dysregulation of this process leads to severely...
Community-Engaged Modeling and Implementation Science to Develop Re-Linkage Interventions for Black Sexual Minority Men with HIV
ABSTRACT Background: Black sexual minority men (SMM) are disproportionately impacted by HIV and multiple social determinants of health (SDOH), such as housing instability, unemploy...
Use of gold-based photothermal nanomaterials for the comminution of kidney stones
Project Summary (30 lines max): The goals of this proposal are to develop a novel nanotechnology based treatment for kidney stones and also to support the career development of Ian...
The Effectiveness of Adjuvant Adenoidectomy in Surgical Management of Otitis Media
Project Summary / Abstract Dr. Kavita Dedhia is an assistant professor in otolaryngology at the University of Pennsylvania (UPENN) and Children’s Hospital of Philadelphia (CHOP). S...
In situ cryo-EM of protein condensates in the early secretory pathway of neurons
Neurons are highly polarized cells that exhibit distinct moieties that serve to receive (dendrites) and transmit (axons) electrochemical signals. In a variety of neurodegenerative...
Targeting cDC1 with CAR T cells to investigate their role and potential as a therapeutic target in Type 1 diabetes
PROJECT SUMMARY Type 1 diabetes (T1D) is the second most common disease of childhood which results in substantial morbidity and mortality. This autoimmune disease is characterized...
Preparing for a clinical trial to implement a fully implanted neuroprosthesis to restore walking after partial paralysis
The long-term objective of this project is to improve the walking speed and stability of Veterans disabled by incomplete SCI (iSCI), stroke, or multiple sclerosis sufficiently to s...
Microbiome-Mitochondrial Interactions Driving Cancer-Induced Cachexia in the Obese State
PROJECT SUMMARY Research: At the time of cancer diagnosis, 40% - 60% of patients are overweight or obese. Despite this, there is a dearth of literature on the impact of weight stat...
A Multilevel Investigation of Migration and Dementia Risk Among Mexican Americans
ABSTRACT The US-Mexico migration corridor is one of the busiest in the modern era. In the United States, over 15 million adults ages 50+ are foreign-born, most of Mexican origin. A...
A novel transcriptome-connectome approach to study the neurogenetic mechanism of nicotine and cannabis addiction
ABSTRACT Substance use disorders (SUDs) are complex and heritable mental disorders and serious public health challenge with uncontrolled use of substances like tobacco, alcohol and...
Optimizing CNS DHA delivery in elderly adults at risk for dementia
ABSTRACT There exists an urgent need to develop and evaluate early interventions to mitigate neurodegenerative processes in aging adults at increased risk for Alzheimer’s disease (...
Using redox balance to guide surgical and therapeutic decisions for cartilage disease
PROJECT SUMMARY/ABSTRACT The goal of this research project is to develop optical redox imaging (ORI)-based medical instruments to guide surgical and therapeutic approaches in early...
The Role of Tau Phosphorylation in Diabetic Peripheral Neuropathy
Project Summary: Broad Impact: Diabetic peripheral neuropathy is a condition that affects millions of people worldwide. Here we propose a set of experiments that will determine the...
Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 Diabetes
PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is a major cause of death in individuals with type 1 diabetes (T1DM), but the underlying mechanisms are not well understood. D...