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606,025 grants found
Showing 28,641 – 28,660 of 606,025 grants
HTORR Cold Storage Temperature Monitoring Modernization
Project Summary: The Human Tissue and Organ Research Resource (HTORR) is a division of the National Disease Research Interchange (NDRI), a not-for-profit NIH-funded organization wh...
The alterations caused by obese extracellular vesicles on colorectal cancer tumor microenvironment
Project Summary Colorectal cancer (CRC) patients with a high body-mas index (BMI) have poor efficacy to chemotherapy, creating an urgent need to design targeted therapy for this gr...
Lifecycle of obesogenic gender behaviors and cardiometabolic disease in women
Project Summary: Maternal obesity with increased circulating inflammatory markers can lead to adverse pregnancy outcomes, such as preeclampsia (PE). Clinical signs of PE include ma...
Clinical Translation of a Large Oncosome-Based Prostate Cancer Blood Test
ABSTRACT - The focus of this proposal is on lethal, metastatic prostate cancer (PC). The aim of this study is to develop an innovative, minimally invasive, liquid biopsy assay that...
Investigating the molecular signatures and pathways indicative of air pollution toxicity in lung carcinogenesis using single- and multi-omics analyses of genomics, proteomics, and metabolomics
Project Summary Air pollution is a known environmental risk factor for lung cancer, but the detailed mechanisms driving air pollution-induced carcinogenesis and the key molecular e...
Behavioral and neural measures of phonological-to-orthographic transfer in young children
Project summary: A key component in the development of linguistic proficiency is the capacity to learn the statistical regularities present in the ambient language environment, lar...
Multi-modality evaluation of high-risk coronary atherosclerotic plaque
Multi-modality evaluation of high-risk coronary atherosclerotic plaque Summary Non-invasive, quantitative assessment of coronary atherosclerosis will lead to improved, personalized...
Evaluating the roles of healthcare and community factors on healthcare disparities among aging immigrants
PROJECT SUMMARY/ABSTRACT Latinxs are aging faster than other racial/ethnic group in the US. By 2050, they are projected to be the largest share of the immigrant, older population....
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults (BRIO)
SUMMARY In most individuals, exercise counters the onset and progression of chronic diseases (e.g., type 2 diabetes, cardiovascular disease, cognitive decline, and cancers), geriat...
Informatics strategies to improve immune-related adverse event detection in cancer patients
PROJECT SUMMARY/ABSTRACT Immune checkpoint inhibitors (ICIs) have drastically improved cancer survival over the past decade, but this survival comes at the cost of a new class of i...
Integration of Mental Health Services in HIV Care for Adolescents and Youth in Kenya
Project Summary/Abstract Common mental disorders like depression, anxiety and trauma disproportionately affect adolescents and youth with HIV (AYH), and are associated with antiret...
Viper-active: Snake Venom Microbiome as a Source for Bacterially-derived Molecule Discovery
Proposal Summary Historically, venoms have acted as a ‘double-edged sword’ in their impacts on human health. Snake venoms are complex cocktails of bioactive toxins that have been a...
Positive Childhood Experiences and Intergenerational Trauma Transmission
Adverse childhood experiences (ACEs; e.g., abuse, neglect, substance use) exert significant impact on adult health outcomes. Numerous studies have demonstrated a dose-relationship...
Understanding expression and signaling of sex hormone receptors in brain cancers
PROJECT SUMMARY There is significant evidence of cancer-type specific patterns of sex hormone receptor expression and signaling in many central nervous system (CNS) tumors, often c...
Myeloid-derived suppressor cells modulate disease severity in children with viral lower respiratory tract infections
Project Summary Severe lower respiratory tract infection (LRTI) due to viral pathogens remains one of the most common causes of death for young children worldwide. Current manageme...
Hyperexcitability in Alzheimer's Disease
ABSTRACT In the past funding period we focused on hyperexcitability, because several studies in rodents and humans suggested it played an important role in AD pathophysiology. We s...
Local protein synthesis in tau pathology neurodegeneration
PROJECT SUMMARY/ABSTRACT Alzheimer's disease is a progressive, age-related, degenerative brain disease. The most notable symptom is a significant cognitive impairment accompan...
Stellate Ganglia Nrf2 Signaling and Enhanced Cardiac Sympathetic Tone in Chronic Heart Failure
Abstract Excessive oxidative stress has been shown to be a potent pathophysiological mediator in multiple disease states. Cardiac and peripheral sympathetic nerve activity is incre...
Molecular basis of cyclic-di-AMP regulation in Gram-positive bacteria
ABSTRACT Bacteria are surrounded by a cell envelope that is essential for growth, integrity, and pathogenesis. The envelope and the biogenesis pathways that build it are also the t...
Telehealth Use in Nursing Homes and the Quality of Care for Long-Stay Residents with Alzheimer's Disease and Related Dementias
PROJECT SUMMARY/ABSTRACT Expansion of Medicare coverage of telehealth services during the COVID-19 public health emergency (PHE) removed many of the barriers to telehealth provisio...