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606,025 grants found
Showing 28,321 – 28,340 of 606,025 grants
Home-Based, Digital Intervention to Increase Physical Activity in Patients with the Fontan Circulation
SUMMARY/ABSTRACT Patients who undergo cardiac surgeries to establish the Fontan circulation (FC) suffer from lifelong complications and early mortality. Engaging in physical activi...
A mixed-methods study of predictors and outcomes of methadone and buprenorphine receipt during incarceration
PROJECT SUMMARY Individuals with opioid use disorder (OUD) who are involved with the criminal legal system (i.e., incarcerated, arrested) face an increased risk for morbidity and m...
The innate antiviral response in airway epithelium: a cell type-resolved, functional genomics approach
PROJECT SUMMARY Beyond its role in conducting the air required for respiration, the airway epithelium plays a critical role in host defense through its physical and immunological p...
Local Delivery of CCL2 to Reverse Peri-implant Bone Loss in Murine Peri-implantitis
PROJECT SUMMARY In the United States, 3 million people have received dental implants, and it is predicted that 500,000 dental implants will be newly placed every year. While dental...
Mapping Brain Lipid Architecture in Aging, LBD and T Cell Therapy using novel Imaging Mass Spectrometry
PROJECT SUMMARY Dementia with Lewy bodies (LBD) and Parkinson's disease (PD) are characterized pathologically by the presence of Lewy bodies, composed of misfolded alpha synuc...
Molecular design for circuit engineering in the Drosophila brain
PROJECT SUMMARY Understanding how our brain produces complex feelings, decisions, and behaviors is a daunting task. Each of the ~130 trillion synapses in the human brain could pote...
Developing and pilot testing an eHealth decision support tool for young trans women to improve informed decision making about PrEP
Project Summary Transgender women (TW) have the highest rates of new HIV infections in the US yet are less likely to be aware of, use, or adhere to PrEP. This is especially worriso...
Advanced Imaging for Pulmonary Fibrosis
While it is well known that idiopathic pulmonary fibrosis (IPF) has a devastating disease course, approximately 30% of individuals with non-IPF interstitial lung disease (ILD) will...
Preclinical evaluation of physical and biological interventions to reduce post- traumatic joint contracture
PROJECT SUMMARY Post-traumatic joint contracture (PTJC) causes debilitating loss of motion following joint injury and is particularly impactful in the elbow. Clinical treatment is...
Genetic variants guiding pathogenicity of colitogenic T cells
SUMMARY ~2.4 million people in the United States have inflammatory bowel diseases (IBDs). While these severe and debilitating diseases have a genetic component, as determined from...
Advanced Personal Sampler to Assess Occupational Exposures to Bioaerosols
This grant application responds to PAR-18-812: Occupational Safety and Health Research (R01). Exposure to airborne biological agents is known to cause a wide range of negative heal...
Ex Vivo Nanoparticle Drug Delivery Targeted to Human Allograft Endothelium
7. Project Summary/Abstract Peri-transplantation inflammation of solid organ allografts exacerbates acute cell-mediated rejection and increases late graft loss, primarily caused by...
Developing new mouse models of andropause for ADRD research
PROJECT SUMMARY/ABSTRACT Aging and AD are associated with a decline in sex hormones. Approximately 40% of men over 45-years old suffer from low androgen levels. Endocrine aging in...
Eosinophils as Effectors of Antibacterial Immunity in the Lungs
Pneumonia results from uncontrolled lung inflammation and injury often triggered by viral/bacterial pathogen insults. Pneumococci, instigating agents of bacterial pneumonia, are in...
Digital Tools for Precision Nephrology
PROJECT SUMMARY/ABSTRACT This K08 application proposes to establish robust phenotyping pipelines for detection of early Collagen Type IV-Associated Nephropathy (COL4A-AN) using ele...
Developmental mechanisms in the formation and function of sensory-motor circuits responsible for suckling and mastication.
Project summary The sensory-motor circuits are specialized neuronal networks that modulate movement. During development, the proper circuit assembly is fundamental in performing co...
Tumor-Immune Interactions and Cisplatin Resistance in Bladder Cancer
Project summary This K08 Career Development Award proposal for Dr. Filipe de Carvalho describes a research plan and career development program leading up to an academic career as a...
Optimizing PrEP uptake for African American women in the South by empowering women to make informed HIV prevention and sexual health choices
Project Summary Black women are disproportionately impacted by HIV accounting, for 54% of new infections while constituting only 13% of women in the US in 2019. These disparities a...
Demography of Immigrant Mortality in the United States: Leveraging Novel Census Linkages to Death Records, Earnings Trajectories, and Residential Mobility
PROJECT SUMMARY In this project, we study the mortality experience of the U.S. foreign-born population in unprecedented detail leveraging innovative individual-level data linkages...
NOX2 Small Molecule Inhibitors as a Therapeutic Strategy in the Treatment of Alzheimer’s Disease
Alzheimer’s Disease (AD) and related dementias are neurodegenerative disorders of paramount importance, in particular as medical advances continue to extend human lifespans and as...