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606,025 grants found
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Harnessing Extracellular Vesicles to Overcome Radiation Resistance in Pediatric Diffuse Midline Glioma
PROJECT SUMMARY Diffuse midline gliomas with H3K27M alteration (DMG-H3K27M) are the leading cause of pediatric brain tumor-associated deaths. All DMG-H3K27M becomes resistant to ra...
Human papillomavirus mRNA detection for assessing cervical cancer risk in resource-limited settings
ABSTRACT Cervical cancer is highly preventable with early detection and treatment, but due to lack of accessible early screening options, incidence and mortality are still very hig...
Targeting Dysregulated Maturation Program in PSC-Cardiomyocytes
Pluripotent-derived cardiomyocytes (PSC-CMs) remain immature in phenotype and function, and the lack of maturity has now emerged as a major concern in their clinical application. H...
An In-depth Examination of Psychological Distress among Black Breast Cancer Survivors
PROJECT SUMMARY Psychological distress is an important component of cancer care, and can adversely affect treatment compliance, quality of life and survival. Data about psychologic...
Developing a suicide prevention intervention for people with HIV in South Africa
PROJECT SUMMARY/ABSTRACT Background: Suicide in people with HIV (PWH) is an unaddressed public mental health concern in South Africa. Research on suicidal ideation and behavior is...
Dissecting the genetic basis of cancer immune evasion in squamous cell carcinoma
PROJECT SUMMARY/ABSTRACT While immunotherapies have revolutionized cancer treatment, a subset of patients, particularly those with squamous cell carcinomas (SCCs) found in the skin...
Informing mechanistic rules of agent-based models with single-cell multi-omics
PROJECT SUMMARY Cancer is driven by interactions between diverse cell types and their tissue microenvironment. Emerging single- cell and spatial transcriptomic systems are mapping...
The Impact of APOL1 Copy Number Variation on Kidney Disjavascript:autoSave('https://apps.era.nih.gov:443/gmii/home.era?menu_itemPath=59%27)ease Susceptibility in African Americans
Project Summary African Americans are three to four times more likely to develop kidney failure than other populations. Coding variants in Apolipoprotein L1 (APOL1), termed G1 and...
The Role of Social Determinants in Reproductive Coercion: Understanding Health Information and Support Needs
PROJECT SUMMARY/ABSTRACT: In the United States, more than 10 million women have reported experiencing reproductive coercion (RC) by an intimate partner during their lifetime. This...
Investigating microphthalmia-associated transcription factor (MITF) and growth factors as initiators of melanoma
ABSTRACT Melanoma is the deadliest type of skin cancer. It can be cured with surgical resection if detected early, so advancing methods of prevention and early detection for melano...
Estimating the direct and indirect effects of a status-neutral person-centric intervention on HIV transmission among PWID in India
7. PROJECT SUMMARY / ABSTRACT Given the complex socio-structural barriers that PWID face, models of care need to shift from disease-centric models to status-neutral person-centric...
Airway inflammation and fear: elucidating immune mediators and neural substrates
PROJECT SUMMARY: Fear regulation is essential for optimal mental health. Maladaptive fear is a hallmark of posttraumatic stress disorder (PTSD), a debilitating condition afflicting...
Optimism and Dementia-Related Health Outcomes
ABSTRACT Substantial research demonstrates dispositional optimism is related to reduced mortality; fewer studies evaluate optimism specifically in relation to cognitive health - de...
Elucidating racial and ethnic differences in functional effects of the vaginal microbiome in ovarian cancer
ABSTRACT. This K22 proposal aims to enhance the applicant’s prior quantitative training with a combination of formal coursework and informal guidance to transition to independence...
Neurocomputational mechanisms of serotonin, sustained stress, and mental effort allocation
Project Summary/Abstract Human beings have a remarkable capacity for exerting cognitive control to achieve their goals, even though performing such tasks can be stressful (e.g., ge...
The Role of Platelet-Derived Transforming Growth Factor Beta in Abdominal Aortic Aneurysm
PROJECT SUMMARY/ABSTRACT Abdominal Aortic Aneurysm (AAA) is the 15th leading cause of death in the United States with a ruptured aneurysm resulting in an 80% likelihood of mortalit...
The role of hexokinase 2 in liver fibrosis and NASH-induced HCC
Hepatic fibrosis is a major cause of mortality in patients with non-alcoholic steatohepatitis (NASH). Hepatic fibrosis also plays a major role in the development of hepatocellular...
Development of Tunable Microenvironment-Responsive CAR T Cells Using Synthetic Gene Circuits to Enhance Potency and Safety
PROJECT SUMMARY Ovarian cancer is the most lethal malignancy of the female reproductive system, and despite advances in understanding of the disease, therapeutic options for treati...
Exploring the role of Imidazole Propionate on Alzheimer’s Disease and Related Dementias
Project Summary: Alzheimer's Disease (AD) and AD Related Dementias (ADRD) continue to present serious challenges in the aging population and there is a significant need to ide...
Prescribing Cascades among Nursing Home Residents with ADRD
PROJECT SUMMARY Polypharmacy, usually defined as the concurrent use of five or more medications, occurs in over 90% of nursing home (NH) residents with Alzheimer’s Disease and Rela...