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606,025 grants found
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Ubiquitin-mediated regulation of kinetochore assembly and function
Project Summary/Abstract An organism’s ability to grow, develop, and reproduce are some of the defining characteristics of life. Central to growth and reproduction of organisms ran...
Improving the analysis and use of contaminated immunoassays: from methods development to implementation
PROJECT SUMMARY Immunoassays – tests that estimate the concentration of analytes in a sample using antibody-antigen binding reactions – are widely used for clinical diagnostics, bi...
Immune Mechanisms in Cervical Dystonia
PROJECT SUMMARY/ABSTRACT Dystonia is a disabling neurologic disorder, affecting more than 3 million people worldwide. It is characterized by involuntary, painful muscle contraction...
Major Histocompatibility Complex I regulation of microglial function in aging and Alzheimer's Disease
Abstract: Systemic and CNS sterile inflammation (inflammaging) are proposed drivers of brain aging and neurodegenerative diseases (e.g., Alzheimer’s disease, AD). Microglia, the re...
Preparing Indigenous Scientists to Lead Innovative Substance Use Research: The Native Children's Research Exchange Scholars Program
PROJECT SUMMARY/ABSTRACT Indigenous populations in the United States (American Indian, Alaska Native, and Native Hawaiian) face significant substance use disorder inequities. The N...
Rehabbing with Peloton: Commercially Available Fitness mHealth for Cardiac Rehabilitation among Individuals Recovering from Transcatheter Aortic Valve Replacement
ABSTRACT The proposed project is a resubmission by two promising Early-Stage Investigators as multiple principal investigators (PAR-22-189). The overall goal of this multi-phase pr...
Caregivers Preparing for Their Own Health Care Emergency
Summary The overarching goal of the proposed work is to engage spousal caregivers of patients with dementia to plan for their own health emergency. Serious, unexpected health event...
Investigation of within Household Transmission of Influenza in Low-Resource Settings
Abstract: Seasonal influenza causes a significant burden of disease in low-middle income countries, specifically in some of the most vulnerable populations such as infants, pregnan...
Lac operon-dependent metabolism in Enterobacteriaceae and its role in liver disease-associated infections
PROJECT SUMMARY Dysbiosis, an alteration of the gut microbiome associated with chronic diseases, has been previously described in patients with cirrhosis. Common features of dysbio...
COLD-ADAPTED BIOREFINERY CONCEPT FOR ENERY EFFICIENT AND CARBON NEUTRAL VALORIZATION OF WASTE FROM FOOD SYSTEMS
Sustainable management of waste from food systems to recover value-added products such as bioenergy, chemicals, and nutrients using bio-based production processes is crucial in the...
Sámi democratic engagement in the energy transition: advancing justice, legitimacy and participatory governance
The project investigates Sámi democratic participation as a key element for the legitimacy of energy transition in Norway, Sweden and Finland through four interconnected aims:(1) d...
ROOM TEMPERATURE SUPERRADIANT PEROVSKITE LASERS
Coherent light sources are limited to state-of-the art lasers such as free-electron gas or solid-state semiconductor gain media stabilized to high-quality optical cavities.However,...
Training Wind Energy Experts on Digitalisation
Training Wind Energy Experts on Digitalisation (TWEED) Doctoral Network (DN) aims to train the next generation of excellent researchers equipped with a full set of technical and co...
NIHR Short Placement Award for Research Collaborations 2023
Training Award
Thermal Recovery of Functional Coatings (TReFCo)
When devices such as computers, smart phones and batteries are sent for recycling not all of the materials are captured for use in new devices. The metals are most likely to be rec...
Community and Infrastructure Resilience to Climate-geological Long-term Effects (CIRCLE)
Climate change and related perils pose direct threats to coastal communities and accelerate the accumulation of disaster impacts, thereby shortening times between successive hazard...
Hyperuniform Disordered Metasurfaces for Selective Absorbers
In this proposal we aim to develop photonic materials in which novel types of structuring are exploited as a resource to control light absorption and thermal emission. This will de...
Unleashing the power of the circadian rhythm to tackle metastasis
Metastasis, the spread of cancer cells to other parts of the body, is the main reason for cancer-related deaths.I have recently made the remarkable discovery that metastasis is reg...
Airborne Multistatic Radar Systems 2
Purpose and goal:The goal of the project is to study and propose methods that can be used for airborne multistatic radar (AMR). The research includes new methods that reduces the r...
Introduction of new Titanium material forms in Containment Structures
Purpose and goal:The project aims to study how titanium alloys produced with additive manufacturing processes can be used in engine structures with containment requirements. To suc...