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606,025 grants found
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Computational Models for Smart CO2 Monitoring
Project Summary Among the vital signs of human health, respiratory parameters are key indicators of the physiological status of the human body. Particularly important to clinicians...
Noninvasive assessment of in vivo tissue loads following treatment of volumetric muscle loss
PROJECT SUMMARY/ABSTRACT Volumetric muscle loss (VML) is a debilitating condition that leads to chronic functional impairment due to the irrecoverable loss of muscle tissue. There...
Quantification and Classification of Aqueous and Vitreous Inflammation in Uveitis Using Deep Learning Analysis of Ultrahigh-Resolution OCT
PROJECT SUMMARY Uveitis is a common cause of blindness in the United States. The specific cause of uveitis is often unknown, making it difficult to implement targeted testing and t...
Exploring TMEM106B in Neurodegeneration: Protein Interaction and Fibril-induced Neurotoxicity
PROJECT SUMMARY The increasing aging population presents a heightened risk of neurodegenerative diseases. Frontotemporal dementia (FTD) is one of these disorders and is the most co...
Improving treatment of lactation mastitis: leveraging claims data to fill evidence gaps
SUMMARY Lactation mastitis is an extremely painful and debilitating condition that affects 10-25% of breastfeeding people and can progress to breast abscess or septic fever. This s...
Advancing Diagnosis of Dementia in Primary Care Practice(ADDPCP)
PROJECT SUMMARY As the U.S. population ages, the number of people with Alzheimer’s disease and related neurodegenerative diseases (NDDs) that cause dementia will grow. Emerging dis...
Dopaminergic Mechanism for Familiarity and Memory Interference
Abstract Early signs of age-related cognitive decline are associated with deficits in novelty processing. Older individuals often mistake new events for familiar ones. This bias fo...
Nanofiber Patch with Gradient Presentation of Biomolecules for Treatment of Pediatric Tracheal Stenosis
PROJECT SUMMARY The long-term objective of this application is to bring a trachea patch to the market for treatment of pediatric tracheal stenosis, or narrowing of the airway, whic...
Mitochondria-targeted therapy to improve metabolic health post-menopause
SUMMARY Mitochondrial dysfunction in post-menopausal women due to loss of estradiol (E2) alone or in combination with age-induced accumulation of reactive oxygen species (ROS) may...
Analytical Infrastructure for Multiple Sample Single Cell Genomic Data
Project Summary Single cell genomic technologies are fast evolving technologies capable of measuring a variety of omics data modalities in individual cells. With a wide range of ap...
Comparing post-test genetic counseling with and without pre-test counseling: The evolving landscape for optimizing cancer care
Project Summary (Abstract) The number of people who qualify for hereditary breast and ovarian cancer (HBOC) genetic testing has outpaced the number of genetic counselors qualified...
Dopamine and sensorimotor function in stuttering
Stuttering is a disorder of speech fluency that affects 3.5 million people in the USA alone. The primary symptoms consist of involuntary repetitions and prolongations of speech sou...
Engineering biomimetic 3D printed urethral tissue constructs using elastin-based bioinks for urethroplasty
Project Summary Urethral defects requiring urethroplasty occur in children and adults secondary to congenital, traumatic, infectious, and malignant conditions. Current tissue sourc...
Data-driven Diagnostics using Multimodal- AI Assisted Approaches for Early Cancer Detection
Project Summary: The vast majority (90%) of cancers are epithelial in nature, and oral squamous cell carcinoma (OSCC) accounts for a portion of these cases by afflicting 744,884 pe...
Fast Multi-Functional 3D Imaging of Cellular Activities in Deep Tissue
PROJECT SUMMARY We propose to develop and disseminate an advanced 2p Bessel beam light sheet (2pBLS) microscopy instrument for high-speed sub-micron-resolution volumetric imaging i...
The interface of neurons and cancer
Project Summary The F99 portion of this proposal investigates the role of the brain enriched E3 ubiquitin ligase TRIM9 in melanoma progression. The K00 portion of this proposal inv...
Precision HIV Prevention: Piloting a youth learning health community
Despite the substantial declines in HIV transmission achieved over the past decade, the full benefits of available tools and interventions have yet to be realized in youth. This di...
Identifying and Targeting Drivers of Impaired Translation in Tumor-infiltrating CD8+ T-cells.
PROJECT SUMMARY/ ABSTRACT Immune checkpoint blockade (ICB), aimed at reinvigorating immune cells such as T-cells, has exhibited clinical success in a subset of patients yet fails t...
Virtual Digital Histopathology with Explainable Deep Learning for Prostate Cancer Diagnosis
Project Summary Adoption of digital histopathology has increased demands for gigapixel image analysis tools and methods for clinical applications. Integration of deep learning algo...
High-dimensional Mediation Analysis of Cardiovascular Traits with Multi-omics Data
Abstract Cardiovascular disease (CVD), including coronary heart disease (CHD) and stroke, is the leading cause of mortality and morbidity in both men and women in the US. Well-esta...