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606,025 grants found
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Using AI on Routine Clinical and Imaging Data from Acute Stroke Encounter to Predict Post-Stroke Vascular Contributions to Cognitive Impairment (AI - RESPECT)
Project Summary Poststroke cognitive impairment (PSCI) was found to be common in various research studies. PSCI is ideally recognized through cognitive screening and test but they...
Competence, Autonomy, Relatedness, and Connections (CARe Connections): A Peer-Led Intervention Designed with Parkinsons Disease & Related Disorders Carepartners to Improve Holistic Support
Lewy-body dementia (LBD) is a neurodegenerative illness and the most common of a spectrum of Parkinsonian disorders called Parkinson’s and related disorders (PDRD).Notably, Lewy-bo...
D-CARE End of Life Study
Several dementia care management models have been developed to comprehensively meet the needs of the growing number of Americans living with dementia and their caregivers. In 2018,...
Testing just-in-time adaptive interventions (JITAIs) to prevent goal disengagement in response to weight regain following behavioral weight loss treatment
PROJECT SUMMARY/ABSTRACT Weight regain after behavioral weight loss (BWL) treatment is extremely common and a major barrier to healthy weight control. Following BWL treatment, part...
Effects of embedded Acceptance and Commitment Training in DVM and RVT programs as students transition into the workforce
Project Summary/Abstract This is an R01 application to prospectively evaluate an asynchronously-delivered intervention (“Unburdened”) that targets reactivity to difficult client in...
Replication fork protection and innate immune response
ABSTRACT Protection of stalled replication forks is crucial for cells to respond to replication stress and maintain genome stability. Recent research has provided strong evidences...
Striatal Trans-Synaptic Signaling Mechanism in Parkinsonism
Summary: In the United States alone each year an estimated 60,000 individuals are diagnosed with Parkinson's disease (PD) with an economic cost of over fifty billion dollars e...
Implementation of a Community-Based Cancer Prevention Intervention with a Marginalized Population Experiencing Food Insecurity
PROJECT SUMMARY/ABSTRACT Food insecurity is a strong mediator in the relationship between poverty and breast cancer mortality in the United States. National data has identified adu...
Identifying Multimodal Predictors of Response to Parent-Based Treatment for Pediatric Anxiety
Anxiety disorders are the most prevalent childhood psychiatric disorders, impacting up to one third of youth. Pediatric anxiety disorders are highly impairing and, when not effecti...
Hyperactivity of the thalamo-hippocampal-prefrontal circuit as a mechanism for anxiety in Alzheimer disease - Resubmission - 1
PROJECT SUMMARY/ABSTRACT Anxiety is a highly prevalent symptom in the early stages of Alzheimer disease (AD), with correlation to AD biomarkers and association with faster decline....
Video-oculography: A novel approach towards clinical markers of vestibular function and recovery
PROJECT SUMMARY Loss of vestibular function causes visuospatial misperception, imbalance, and decreased visual acuity during head motion, leading to severe impairment of daily acti...
The role of stress physiology and reproductive hormones in the relationship between cannabis use and sleep in women of childbearing age
ABSTRACT This proposal aims to characterize the unique effect of recreational cannabis use on sleep in women. Sleep was once believed to be a quiescent state, where self-reported m...
National Center for Construction Safety and Health Research and Translation
Project Summary/Abstract: The objective of our Center is to conduct research that leads to the reduction of injuries and illnesses and improves worker well-being at a national scal...
CT-based Characterization of Lung Volume-determined Airway and Chest Wall Deformation Interdependences in COPD
AbstractOverview: This research study will leverage established datasets from nationwide longitudinal lung studies to characterize multi-volume mechanical changes affecting airway...
Development of an innovative Non-Invasive MR Imaging Technique for assessing Membrane Lipids and Their Properties in Alzheimer's Disease
PROJECT SUMMARY Phospholipids, the fundamental components of cell membranes, play a crucial role in brain function. Research indicates that changes in membrane lipid composition an...
WNT Mediated Induction of Schwann Cell Plasticity
PROJECT SUMMARY Disorders of the peripheral nervous system, particularly those that affect motor function and pain sensitivity are major clinical challenges. Current medications ar...
Understanding Utilization of Diabetes Self-Management Education and Support Using Social Network Analysis
PROJECT SUMMARY Diabetes Self-Management Education and Support (DSMES) addresses the clinical, psychological, and behavioral aspects of care needed to successfully self-manage diab...
Hypoxia-Induced Misdirection: Understanding Postnatal Inhibitory Interneuron Migration in Neonatal Hypoxic Injury
PROJECT SUMMARY/ABSTRACT The development of the infant brain is a dynamic, intricate process that, when disrupted, can lead to long-term neurological disability. In humans, new inh...
Genetic Modeling the Integration of Biological Sex, Immunity, and Metabolism
PROJECT SUMMARY There is a fundamental gap in the understanding of how biological sex impacts highly integrated innate immune and metabolic responses to affect individual infection...
The contribution of mitochondrial DNA damage to diabetes-related beta-cell failure
PROJECT SUMMARY This F32 proposal describes a comprehensive training and mentorship program for Dr. Rebecca Davidson, a postdoctoral research fellow in the Department of Internal M...