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Project 3: Antagonistic Mechanisms of BRCA2 and the 53BP1 Axis in RAD51 Nucleoprotein Filament Assembly
Project Summary Homology-directed repair (HDR) is a major, high-fidelity pathway for the elimination of DNA double-strand breaks (DSB)s and for DNA replication fork maintenance. De...
Core 1: Protein Biochemistry and Enzymology (PBE) Core
ABSTRACT DNA double-strand breaks (DSB)s are eliminated primarily through two mechanistically distinct pathways, namely, non-homologous DNA end joining (NHEJ) and homology-directed...
Core 2: Chromosome Replication and Analysis (CRA) Core
ABSTRACT Failure to properly repair DNA double-strand breaks (DSBs) or damaged DNA replication forks leads to chromosome aberrations and neoplastic transformation of cells. Homolog...
Core 3: Structural Biology and Biophysics (SBB) Core
ABSTRACT The Structural Biology and Biophysics (SBB) Core will provide Program Project Investigators with high-qual- ity atomic resolution mapping and quantification of salient pro...
Multiphoton intravital microscope
ABSTRACT The Albany Medical College (AMC) Imaging Core Facility, representing the imaging needs from multiple NIH-funded investigators, proposes to acquire an Olympus FVMPE-RS mult...
Developing a Cancer Galaxy Computational Workbench to Meet Emerging Cancer Data Analysis Needs
PROJECT SUMMARY Computational analyses have become instrumental to cancer research, but only a minority of cancer researchers are computational scientists. Cancer researchers—espec...
Closed-Loop Triaxial Optically Pumped Magnetometers for High-Sensitivity and High-Bandwidth Magnetoencephalography Measurements of the Developing Brain
PROJECT SUMMARY/ABSTRACT Non-invasive detection of gamma oscillations in infants will inform a broad range of studies examining neuro- developmental and neurodegenerative disorders...
BD FACSDiscover S8: A multi-laser spectral cell sorter with BD CellView Image Technology
Project Summary/ Abstract The aim of the Robert H. Lurie Comprehensive Cancer Center Flow Cytometry Core Facility is to provide analysis and cell sorting to enhance scientific inte...
Systems biology of acute and chronic multi-organ failure in children with congenital heart disease
PROJECT SUMMARY Approximately 25% of children with congenital heart disease (CHD) require intervention in the first year of life. Although surgical mortality has decreased, the inc...
The role of tetraspanin-regulated endolysosomal trafficking in Alzheimer's Disease
Although the accumulation of Aβ and subsequent chronic inflammation and neuronal dysfunction likely contribute to the development of Alzheimer’s disease (AD) pathology and clinical...
Elucidating the role of IRF4 in reprogramming the tumor microenvironment in follicular lymphoma
PROJECT SUMMARY/ABSTRACT Despite a characteristic indolent course, a substantial subset of follicular lymphoma (FL) patients has an early relapse with a poor outcome. Thus far, eff...
A pulse-labeling assay to track extracellular vesicle spreading in the brain
PROJECT SUMMARY Extracellular vesicles (EVs) are nano-sized secreted vesicles that carry biomolecules and mediate cell-cell communication. EVs are implicated in the development and...
Improving CAR T-cell therapy for Pediatric B-cell Acute Lymphoblastic Leukemia (B-ALL)
PROJECT SUMMARY My long-term career goal is to develop an independent research program focused on evaluation of novel cellular therapies designed to improve long-term outcomes for...
Aging and sensory contributions to spatial orientation
Spatial perception is based on various sensory inputs processed within a widely-distributed cerebral network. Cur- rently it is not known how these multisensory mechanisms and thei...
WNT signaling in chondrocyte biology and osteoarthritis
Abstract Hip osteoarthritis (OA) affects one in four people by the age of 85, and it is linked to abnormal hip morphology including Cam-type femoroacetabular impingement (FAI). Hen...
Targeting mitochondrial oxygen demand to overcome hypoxic immune privilege of NSCLC tumors
ABSTRACT Non-small cell lung cancer (NSCLC) is a highly aggressive disease with dismal prognosis associated with high rates of treatment resistance and disease recurrence. In the l...
Three-dimensional One-step Aptamer Selection in the Non-fouling Macroporous Hydrogel
Project Summary Nucleic acid aptamers (aptamers) have been used as therapeutic agents or delivery ligands for various biomedical applications such as regenerative medicine, cancer...
Zeiss LSM 900 with Airyscan 2
PROJECT SUMMARY Columbia University Irving Medical Center (CUIMC) has been a leading center for the study of diabetes, obesity, atherosclerosis, non-alcoholic fatty liver disease a...
Optic Nerve Relays for Vision Restoration and Advancement Optic Nerve Regeneration Research
Project Summary/Abstract Optic neuropathies and retinal diseases are leading causes of irreversible blindness worldwide. Currently, there are no therapies to restore vision loss. W...
Preparing Nurse Scientists to Lead the Future of Oncology Research
Until recently, the concept of the “oncology nurse” was limited to those having extra competency in administering chemotherapy, coordinating care delivery, or working with investig...