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A novel murine model of 2-Hydroxyglutaric aciduria
Compound heterozygous missense mutations of the SLC25A1 gene give raise to combined D/L-2- HydroxyGlutaric Aciduria (D/L-2HGA) [1-10], a disease hallmarked by the accumulation of t...
Training Health Equity ScholaRs in InnoVation, PrEvention, and Social Impact (THRIVES) Fellowship Program
UC Berkeley Training HealthEquity ScholaRs in InnoVation, PrEvention, and Social Impact (UCB-THRIVES) Fellowship Program Despite extensive research documenting the existence of per...
Life-course acculturation trajectories and dementia in a multi-ethnic cohort of older adults: The MESA Acculturation and dementia Study
PROJECT SUMMARY/ABSTRACT There has been increasing emphasis on understanding the social-contextual factors that contribute to risk of Alzheimer’s Disease and related dementias (ADR...
Photoreceptor induction in wounded corneas
Project Summary/Abstract The cornea is the optically clear, curved tissue that provides the majority of refractive power in the eye. Improper healing of corneal wounds is a serious...
AI-guided miniproteins driving the production and functional endurance of pancreatic islet tissue from pluripotent stem cells.
Summary Stem cell (SC)-based replacement therapy is emerging as promising cure for diabetes. However, population-wide applicability of this approach remains constrained by the limi...
Cellular and developmental genetic regulation of 3' isoform diversity in the human brain and its contribution to neuropsychiatric disorders
PROJECT SUMMARY/ABSTRACT As large-scale genome-wide association studies (GWAS) continue to yield now thousands of genomic loci robustly associated with neurodevelopmental and psych...
CoCM-PAL: Adapting Collaborative Care for Older Adults with Serious Illness and Comorbid Depression or Anxiety Receiving Ambulatory Palliative Care
Project Summary/Abstract Dr. Daniel Shalev is an Assistant Professor of Medicine and Psychiatry at Weill Cornell with expertise in psychiatry, palliative medicine, and behavioral g...
Defining nuclear mechanisms for ultrarapid mechanically induced gene expression
Project Summary Cells in the human body are exposed to a broad range of mechanical forces. Cells respond to such mechanical stimuli with the expression of specific mechanoresponsiv...
Identification of proteins for breast cancer risk: an integrative epidemiologic and genomic study
Project Summary Genome-wide association studies (GWAS) have identified over 200 genetic loci for breast cancer. To translate these findings into an improved understanding of cancer...
Impact of lipids and food on oral compound absorption: mechanistic studies and modeling
Lipids in drug delivery systems and food can have a tremendous impact on the systemic absorption of orally delivered compounds, including drugs, nutrients, and toxins. However, thi...
Backpack Hydration System Use Among Farmworkers
PROJECT SUMMARY Agriculture is one of the most dangerous occupations in the United States, including a disproportion risk of death from heat-related illnesses (HRIs). Proper hydrat...
A multiscale computational and experimental platform to investigate cardiomyopathies and targeted therapeutics
PROJECT SUMMARY In deadly and common familial hypertrophic and dilated cardiomyopathies, structural variation at the single protein level leads to adverse ventricular remodeling, s...
Investigating the cell intrinsic and extrinsic mechanisms governing lung cancer cell plasticity
PROJECT SUMMARY During tumor evolution, cancer cells can acquire phenotypic heterogeneity, enabling them to grow more aggressively, invade neighboring tissues, evade the immune sys...
New siRNA therapeutics to halt diabetic kidney disease
PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) is an urgent health problem in the U.S., afflicting ~15% of Americans and costing the healthcare system $120 billion/year. Des...
Inner ear infection and innate immunity
ABSTRACT The inner ear is perfused by vessels that provide oxygen and nutrients to support the activity of hearing. This separation between the blood and inner ear fluids is mainta...
Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis
ABSTRACT DNA double-strand breaks (DSB)s occur upon exposure of cells to ionizing radiation and chemicals in the environment, and when DNA replication forks become impeded by lesio...
Admin Core: Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis
ABSTRACT DNA double-strand breaks (DSB)s occur upon exposure of cells to ionizing radiation and chemicals in the environment, and when DNA replication forks become impeded by lesio...
Setting the Agenda: Empowering people with CKD in rural America through participatory research to develop, implement and trial a clinical visit agenda-setting intervention
PROJECT SUMMARY/ABSTRACT People living in rural areas with chronic kidney disease (CKD) experience understudied and under-addressed challenges. U.S. CKD prevalence is higher in rur...
Neuroplasticity and early cochlear implant use
PROJECT SUMMARY/ABSTRACT Adult mammalian brains have a remarkable plasticity, but its study in humans is challenging to conduct because real-world needs and experiences are frequen...
Single-molecule nanopore-based identification of methylome signatures in cfDNA for early colorectal cancer detection
ABSTRACT The detection and characterization of cell-free DNA (cfDNA) is increasingly being used to detect cancer – this modality is frequently referred to as a liquid biopsy. Epige...