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606,025 grants found
Showing 28,141 – 28,160 of 606,025 grants
Metabolic therapy for atrial fibrillation
Atrial Fibrillation (AF) is the most common arrhythmia in the United States (US) with an estimated prevalence of 5 million and is expected to increase to 12 million by 2030. AF pos...
Disparities in undiagnosed and misdiagnosed dementia and the impact on health care utilization and costs - a novel approach using probabilistic dementia classifications
PROJECT SUMMARY/ABSTRACT Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) are the costliest diseases in the U.S. Yet they often go undiagnosed or get diagnos...
Mechanisms of spindle organization for cell division
During cell division, the precise positioning of the cell-cleavage plane at the center of a ~ 10-15 um long cell is essential for maintaining genome integrity. Consistently, cytoki...
The metabolic clock as a regulator of cell fate decision
Project Summary: Our organs respond dynamically to changes in the body’s demands by adapting both their size and activity levels. In these processes, mechanisms governing cell fate...
Molecular determinants of condensate assembly in heterogeneous environments
Project Summary Biomolecules, including proteins, nucleic acids, and metabolites, must first colocalize in order for biochemical reactions to take place. As a result, spatially org...
Advancing visible-light OCT in oxygen-induced retinopathy
PROJECT SUMMARY The oxygen-induced retinopathy (OIR) model has been a valuable preclinical model for understanding the pathophysiology of retinopathy of prematurity (ROP) and ische...
SMALL-MOLECULE AND NUCLEIC ACID ENGINEERING TOWARD MOLECULAR DESIGNS OF THERAPEUTIC POTENTIAL
PROJECT SUMMARY / ABSTRACT Designer small molecules and nucleic acid polymers are essential to the advancement of biotechnology and precision medicine. However, efforts to develop...
Efficacy of Teleconsultation to Improve Prehospital Patient Safety for Critically Ill Infants and Children - A Multicenter, Simulation-based Randomized Control Trial
ABSTRACT The Emergency Medical Services (EMS) 2050 Agenda for Future Systems envisions that telehealth tools could make prehospital care safer and more effective, but few EMS syste...
Financial stress, financial strain, asset depletion, and financial toxicity: New measures to characterize the financial impact that dementia has on families
ABSTRACT Financial hardship (including financial stress, financial strain, asset depletion, and financial toxicity) is a highly relevant construct among the 5.7 million people with...
Improving Biopsychosocial Outcomes of Older Adults Facing Fecal Ostomy Surgery
Project Summary. In this K76 proposal, I outline a comprehensive 5-year training program that will support my transition to independence as an emerging leader. The proposal focuses...
REVAMP-PH: REpurposing Valsartan May Protect against Pulmonary Hypertension
Project Summary Although there has been substantial progress in the development of medications to lower pulmonary vascular resistance in pulmonary arterial hypertension (PAH), ther...
Dynamic retinal coding in natural environments
Project Summary Natural environments present numerous challenges to the visual system, including the presence of large and frequent changes in light intensity. Such changes occur w...
Mindfulness-based Neurofeedback to augment DBT psychotherapy for adults with Borderline Personality Disorder (MIND-BPD)
Project Summary The proposed project is a clinical trial of a mindfulness-based neurofeedback (mbNF) intervention used to augment Dialectical Behavior Therapy (DBT) skills group tr...
Design and Validation of a Pelizaeus Merzbacher Disease (PMD) Severity Scale
Abstract: Pelizaeus Merzbacher Disease (PMD) is a rare X-linked hypomyelinating leukodystrophy caused by pathogenic variants in PLP, which encodes proteolipid protein 1 (PLP1) and...
Patient-Centered Outcomes in Carotid Artery Stenosis
Project Summary Abstract Older patients with carotid artery atherosclerotic disease are at risk of stroke, and some evidence suggests that people are affected by their carotid arte...
A novel oral immunotherapy for chronic visceral pain of irritable bowel syndrome
Abstract: Chronic visceral pain is a defining feature of irritable bowel syndrome (IBS) that is currently considered as a disorder of brain-gut interaction. Although pain is the mo...
Age-related Cognitive Changes: Effects of Combined Flavonoid Intake and Physical Exertion Mediated by the Gut Microbiome
Age-related cognitive changes: Effects of combined flavonoid intake and physical exertion mediated by the gut microbiome Age-related cognitive changes can be the first indication o...
ComPASS Health Equity Research Hub at UMB
ABSTRACT Despite decades of concerted efforts to eliminate health disparities experienced by minority racial and ethnic groups and other underserved populations, there remains a cr...
Epigenetics Biomarker of Post Operative Delirium and Long Term Cognitive Decline among Elderly Dementia Patients
PROJECT SUMMARY/ABSTRACT Delirium exposes patients to a greater risk of developing Alzheimer’s disease and dementia, and patients with Alzheimer’s disease and dementia are more lik...
Anesthesia Care Delivery in Rural America: The Impact of Organizational Climate on Burnout, Job Satisfaction, and Intention to Leave among Certified Registered Nurse Anesthetists
Burnout among Certified Registered Nurse Anesthetists (CRNAs) is a growing public health crisis with recent estimates as high as 72%. As CRNAs are the predominant anesthesia provid...