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Role of Mitochondrial Metabolism in Regulating Species-Specific Developmental Rates
All mammalian embryos undergo a highly conserved sequence of developmental events, but different species complete this sequence at significantly different speeds.Astonishingly, emb...
Pulsed Q-band Electron Paramagnetic Resonance Spectrometer for Structural Biology Applications
PROJECT SUMMARY/ABSTRACT The instrument to be acquired is a state-of-the-art Pulsed Q-band Electron Paramagnetic Resonance (EPR) spectrometer and will be a multi-user shared instru...
BD FACSymphony S6
SUMMARY/ABSTRACT This proposal requests funds to purchase a BD FACSymphony S6 flow cytometric sorter to be housed in an active and established core, the Flow Cytometry Core at the...
DEVELOP GENOMEWIDE TECHNOLOGY TO PROFILE DNA ADP-RIBOSYLATION
PROJECT SUMMARY Our research program seeks to develop innovative technologies to investigate the role of ADP-ribosylation, an under-studied DNA modification implicated in critical...
Leveraging Sexual Dimorphism to Predict Cardiac Remodeling and Enhance Treatment in Women with Severe Aortic Stenosis
ABSTRACT Women with severe aortic stenosis (AS), a condition characterized by the narrowing of the aortic valve opening, often experience delayed diagnosis, undertreatment, and hig...
Elucidation of the upstream transcription factors controlling preeclampsia-specific gene expression using human trophoblast stem cells as a model system
PROJECT SUMMARY Preeclampsia (PE) is a relatively common pregnancy disorder that originates from the placenta. It affects up to 8% of all human pregnancies and causes various mater...
Development and Validation of Gaze-based Training for Endoscopic Kidney Stone Surgery
Project Summary The importance of achieving stone-free status during endoscopic kidney stone surgery is emphasized by the high rate of repeat stone procedures due to residual fragm...
A microphysiological model of the brain-lymphatic system in Alzheimer's disease
Summary The nervous system interacts with the immune system in ways that have been identified to contribute to a number of diseases, including Alzheimer’s disease, infection, brain...
Impact of Parental Bereavement on Social Connection, Isolation, and Health
PROJECT SUMMARY/ABSTRACT The pain of loss figures prominently for millions of Americans, and while the emotional toll of bereavement is well-recognized, resulting disruptions to so...
Drd3 transcript variants and cocaine self-administration
Project Summary This proposal is prepared in response to PAR-23-041, which supports projects that functionally validate and/or characterize genes or variants implicated in substanc...
Examining Influences of Place-Based Historical and Contemporary Structural Racism on Racial Disparities in Aging-Related Disease Risk Trajectories: Leveraging the HANDLS Dataset
Project Summary African Americans (AA) are at disproportionate risk for earlier and more pronounced cognitive and functional decline and increased frailty. Structural racism (SR)—t...
Inflammaging and Diabetic Retinopathy
PROJECT SUMMARY Diabetic retinopathy (DR) is a neurovascular complication of diabetes mellitus and the leading cause of blindness in adults. Prevention of hyperglycemia-induced ret...
Protein-Derived Cofactor in Bifunctional Enzyme KatG from Mycobacterium tuberculosis
Protein-derived cofactor in bifunctional enzyme KatG from Mycobacterium tuberculosis Project Description The catalase-peroxidase enzyme KatG is a heme-dependent protein critical fo...
A Novel Aerosolization and Inhalation Platform for the Pulmonary Delivery of Anti-inflammatory Agents to Distal Airways for the Enhanced Pain Management in Chronic Obstructive Pulmonary Disease (COPD)
Project Summary/Abstract Treating inflammation in deep lung would help manage pain in chronic obstructive pulmonary disease (COPD), as pain in COPD patients is often associated wit...
Apply novel pathogenomic approaches to identify interpretable image QTLs for multiple normal tissues
ABSTRACT The overarching goal of this project is to identify tissue-specific genetic variants and genes that are associated with cellular and tissue morphology in normal tissues. W...
Investigating the role of Ldb1 in chromatin architecture and transcription during erythroid cell state transitions
Project Summary Chromatin architecture plays important regulatory roles in gene expression and is critical to maintain cellular identity. However, there are many unanswered questio...
meQTL Discovery in Admixed Human Genomes Facilitates Estimates of Epistasis
Personalized genetics is poised to revolutionize healthcare; however, despite advances, genetic prediction and portability of critical variants remains too limited for clinical use...
AI-MedWise: Developing and validating an artificial intelligence solution for effective video-based monitoring of medication adherence
PROJECT SUMMARY Poor adherence to oral medications is highly prevalent in 40-50% of patients with chronic diseases worldwide.Close monitoring of medication adherence is a critical...
Resistant starch treatment of polycystic ovary syndrome: impact on cardiometabolic dysfunction and the gut microbiome
Hyperandrogenic women with polycystic ovary syndrome (PCOS) have a high prevalence of cardiovascular disease (CVD) risk factors including obesity, insulin resistance, hypertension,...
Skin-interfaced triboelectric sensors continuously monitor worker forceexertions to prevent workplace injuries
Abstract Despite advances in automation, manual material handling (MMH) tasks continue to be commonplace in the workplace. To design and control the high burden of musculoskeletal...